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Obesity, Morbid clinical trials

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NCT ID: NCT05993169 Terminated - Obesity, Morbid Clinical Trials

Body Composition Optimization Intervention RCT

Start date: September 15, 2023
Phase: N/A
Study type: Interventional

This study aims to identify if the addition of structured nutrition/weight loss counseling to patients at the bariatric clinic can increase the conversion from bariatric clinic to surgical candidacy from (the current) 11% to a goal of 20% by way of tracking their BIA measurements.

NCT ID: NCT05427916 Terminated - Diabetes Clinical Trials

Closed Incision Negative Pressure Wound Therapy vs. Foam as Post Operative Dressing

Start date: July 12, 2022
Phase: N/A
Study type: Interventional

The primary objective is to assess the frequency of a wound healing complication, in a closed incisional wound in a "high risk" surgical incision when treated with Negative Pressure Wound Therapy versus a highly absorbent antimicrobial post - operative absorbent dressing.

NCT ID: NCT04940429 Terminated - Clinical trials for Bariatric Surgery Candidate

Eye Movement Testing in Patients With Obesity and the Impact of Weight Loss Surgery

Start date: November 27, 2018
Phase:
Study type: Observational

Obesity is a condition of chronic low-grade inflammation, thought to be secondary to adipose tissue secretion of cytokines including interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF- α) which effect multiple pathways and lead to an increase in C-reactive protein (CRP), a sensitive marker of systemic inflammation. Chronic inflammation is thought to be a major risk factor for the development of metabolic syndrome, diabetes, cardiovascular disease and cancer. Inflammatory cytokines have also been shown to directly and indirectly interact with the central nervous system influencing behavior and neural activity. Obesity is an independent risk factor for reduced cognitive function including poor attention, executive function and memory. Demonstrating improvement in dynamic visual processing following bariatric surgery could expand our understanding of the impact of obesity on central nervous system (CNS) function.

NCT ID: NCT04741074 Terminated - Obesity Clinical Trials

Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy

RAISE-KT
Start date: July 23, 2021
Phase: Phase 3
Study type: Interventional

This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or dialysis-dependent end-stage kidney disease (ESKD) on patients' eligibility for kidney transplantation at the end of 9 months.

NCT ID: NCT04050969 Terminated - Atrial Fibrillation Clinical Trials

Bariatric Atrial Restoration of Sinus Rhythm

BAROS
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to determine whether bariatric surgery followed by Atrial Fibrillation (AF) catheter ablation is superior to AF catheter ablation alone in the management of atrial fibrillation in patients with morbid obesity.

NCT ID: NCT03925610 Terminated - Morbid Obesity Clinical Trials

Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients

Start date: April 10, 2019
Phase:
Study type: Observational

This is an observational study of morbidly obese patients recovering from general anesthesia after weight-loss surgery. The investigators aim to assess ventilatory function and how this is influenced by the diagnosis of obstructive sleep apnea (OSA), baseline ventilatory status, as well as pharyngeal collapsibility of patients who are recovering from anesthesia and treated for pain with opioids. The investigators hypothesize that patients with OSA, chronic (baseline) hypoventilation and increased pharyngeal collapsibility, will be more vulnerable to opioid-induced ventilatory depression.

NCT ID: NCT03528980 Terminated - Obesity Clinical Trials

Impact of Weight Loss Induced by Bariatric Surgery or Nutritional Management on Sexual Function in Men With Severe Obesity

SexOb
Start date: May 2012
Phase:
Study type: Observational

Study of the impact of weight loss induced by surgery (interventional group) or optimal nutritional management (control group) on sexual function in men with severe obesity

NCT ID: NCT03429205 Terminated - Morbid Obesity Clinical Trials

The Efficacy of External Warming During Laparoscopic Bariatric Surgery

Start date: March 15, 2018
Phase: N/A
Study type: Interventional

External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated hot-air pump. The need for external warming in the morbidly obese population undergoing short laparoscopic procedures is unclear. If proven to be unnecessary, time and momentary costs could be lowered. The study will compare core-temperature dynamics during laparoscopic bariatric procedures anticipated to last <2h. The study group will be left without a warming blanket while the control group will receive routine external warming. Post-anesthesia care unit (PACU) arrival temperature will also be recorded.

NCT ID: NCT03405311 Terminated - Pain Clinical Trials

3D Ultrasound-guided Labor Epidural Analgesia in the Morbid Obese Parturient

Start date: February 20, 2018
Phase: N/A
Study type: Interventional

This study will be a randomized control study, with the objective to evaluate epidural analgesia success rates between the two methods (Blind Approach versus Accuro Device).

NCT ID: NCT03269968 Terminated - Obesity, Morbid Clinical Trials

Use of Negative Pressure Wound Therapy in Morbidly Obese Women After Cesarean Delivery

Start date: October 3, 2017
Phase: N/A
Study type: Interventional

Obese women are more likely have a cesarean delivery and develop subsequent wound complications than normal weight women. Negative pressure wound therapy (NPWT) has been shown to improve surgical wound healing, but this device has not been adequately studied in cesarean deliveries. The aim of our study is to determine the efficacy of NPWT in morbidly obese women after cesarean delivery. Investigators will be randomizing women with a BMI > 40 kg/m2 in a 1:1 ratio to either NPWT (the PREVENA Incision management therapy system Pre 1001 Us) or standard dressing after their cesarean delivery at MedStar Washington Hospital Center. The NPWT will be left in place for a minimum of four days but not to exceed seven days. The standard dressing is typically removed on postoperative day one or two. The primary outcome is a wound complication defined as the formation of a wound infection, seroma, hematoma, separation, or dehiscence from delivery to 4 weeks postpartum. Investigators will also administer a patient satisfaction survey regarding their wound healing experience.