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Menopause, Premature clinical trials

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NCT ID: NCT04390308 Not yet recruiting - Infertility, Female Clinical Trials

Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?

Start date: November 23, 2023
Phase:
Study type: Observational

Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.

NCT ID: NCT04381299 Active, not recruiting - Infertility Clinical Trials

Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?

Start date: April 25, 2021
Phase:
Study type: Observational

A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention. To date, applications in orthopedics, wound healing, dermatology and plastic surgery have gained general acceptance, primarily as the role of platelets and their activation in tissue repair and recovery has become better understood at a cellular and molecular level. This study will involve adult women with a diagnosis of Premature ovarian insufficiency (POI) willing to perform an IVF/ICSI treatment.

NCT ID: NCT04306185 Not yet recruiting - IVF Clinical Trials

Ovarian Fragmentation Study (Crespo Medical Team)

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following this procedure in poor ovarian responders and patients with decreased ovarian reserve. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.

NCT ID: NCT04237909 Completed - Clinical trials for Premature Ovarian Failure

Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian Insufficiency

Start date: January 27, 2020
Phase: N/A
Study type: Interventional

Reproductive age women diagnosed with poor ovarian response (POR) based on Poseidon criteria and premature ovarian insufficiency (POI) based on ESHRE criteria and with a history of at least one prior failed IVF cycle will be recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols and will be injected to at least one ovary. Ovarian reserve parameters and IVF outcomes will be determined.

NCT ID: NCT04189406 Recruiting - Infertility, Female Clinical Trials

Turner Syndrome Minipuberty Study

Minipuberty
Start date: February 1, 2020
Phase:
Study type: Observational

Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve fertility in patients with TS. However, in the majority of females with TS , the ovarian reserve is exhausted before the age of menarche. Early markers indicating and predicting the ovarian reserve are necessary. During mid-childhood the hypothalamic-pituitary-gonadal (HPG) axis is quiescent and gonadotropins are usually unmeasurable. Nonetheless, this axis is active during infancy. Therefore, gonadotropins are measurable with peak values at 3 months of age and with lower (but still measurable) values at 9 months of age, in a period called the minipuberty. The aim of this study is to find markers of ovarian capacity, during the minipuberty, in order to predict ovarian reserve in the future. Objective: The hormonal range of LH, FSH, AMH, inhibin B, testosterone and estradiol in girls with TS during the minipuberty and the relation of the hormone serum levels with the karyotype. Study design: A prospective, cohort study with a duration of 3 years. Study population: Girls with a pre- or perinatal diagnosis TS who are born in a medical centre in the Netherlands during the duration of the study Main study parameters/endpoints: Serum levels of FSH, LH, AMH, inhibin B, testosterone and estradiol at the age of 3 and 9 months.

NCT ID: NCT04167033 Recruiting - Clinical trials for Premature Ovarian Insufficiency

Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)

QT-IOP
Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP). The investigators have recently shown that estradiol determines an increase in QTc elongation and progesterone shortens it. In addition, high gonadotropin levels (FSH or LH) are associated with QTc prolongation. Hypergonadotropic hypogonadisms (low progesterone and high gonadotropins) are therefore hormonal situations that promote QTc prolongation. Premature ovarian insufficiency (POI) is one of them. Its management is based on the prescription of hormone replacement therapy (HRT). Epidemiological studies have shown that these patients would be at increased risk of cardiovascular mortality. Our team is interested in the effect of this pathological hormonal situation and its HRT on ventricular repolarization in order to define whether this is a population at risk for long QTc.

NCT ID: NCT04163640 Completed - Infertility, Female Clinical Trials

Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response

Start date: February 24, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to perform a prospective randomized controlled trial seeking to characterize the effects of intra-ovarian injection of platelet rich plasma (PRP) on biomarkers of ovarian reserve as well as IVF outcomes in women with primary ovarian insufficiency (POI) and poor ovarian response (POR) who decline the use of an egg donor to establish a pregnancy.

NCT ID: NCT04149028 Completed - Clinical trials for Premature Ovarian Failure

Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study

NCT ID: NCT04131244 Completed - Clinical trials for Activation of Primordial Follicles

In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian Insufficiency (POI) under age 36.

NCT ID: NCT04082169 Recruiting - Clinical trials for Primary Ovarian Insufficiency

Causes and Consequences of Primary Ovarian Insufficiency

Clinical POI
Start date: January 11, 2019
Phase:
Study type: Observational

100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.