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Menopause, Premature clinical trials

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NCT ID: NCT04922398 Not yet recruiting - Clinical trials for Premature Ovarian Failure

Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency

Start date: June 20, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal & ultrasound & clinically to monitor any changes

NCT ID: NCT04881695 Not yet recruiting - Clinical trials for Premature Ovarian Failure (POF)

Evaluation of Child Desire in Young Women With Premature Ovarian Failure

DESIOP
Start date: May 10, 2021
Phase:
Study type: Observational

Premature ovarian failure (POF) is a rare condition, affecting 1 in 10,000 women before age 20 and 1 in 1,000 women before age 30. The two main causes of POF are congenital and acquired. Patients with POF who carry out the desire to have a child turn to medically assisted reproduction through oocyte donation or to adoption. The main endpoint of this study is to compare the desire to have children among women with premature ovarian failure (POF) aged 18 to 26 years vs. controls of the same age (stratified by age) without major menstruation disorder.

NCT ID: NCT04815213 Recruiting - Clinical trials for Premature Ovarian Failure

The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans

Start date: January 1, 2020
Phase: Phase 1
Study type: Interventional

Autologous bone marrow-derived mesenchymal cells will be injected into patients diagnosed with premature ovarian failure

NCT ID: NCT04800705 Recruiting - Clinical trials for Premature Ovarian Failure

Levels of Selected Macroelements in Premature Ovarian Insufficiency

POI&MACROs
Start date: March 15, 2021
Phase:
Study type: Observational

Aim: To evaluate plasma zinc (Zn), copper (Cu), calcium (Ca), iron (Fe), manganese (Mn), selenium (Se), strontium (Sr), aluminum (Al), antimonium (Sb), phosphorus (P), magnesium (Mg), sodium (Na), potassium (K), barium (Ba) and thallium (Tl) levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects. Methods: This prospective study will be included 70 women with idiopathic premature ovarian insufficiency and 70 controls. The blood/urine/hair for analyses will be obtained at the early follicular phase of the menstrual cycle and plasma zinc (Zn), copper (Cu), calcium (Ca), iron (Fe), manganese (Mn), selenium (Se), strontium (Sr), aluminum (Al), antimonium (Sb), phosphorus (P), magnesium (Mg), sodium (Na), potassium (K), barium (Ba) and thallium (Tl) levels will be measured using inductively coupled plasma-mass spectrometry.

NCT ID: NCT04767451 Recruiting - Clinical trials for Premature Ovarian Failure

Levels of Selected Microelements in Premature Ovarian Insufficiency

POI&MICROs
Start date: February 25, 2021
Phase:
Study type: Observational

Aim: To evaluate plasma/urine/hair Lead (Pb), Cadmium (Cd), Gadolinium (Gd), Arsenic (As), Mercury (Hg), Cobalt (Co), Vanadium (V), Titanium (Ti), Sulfur (S), Chromium (Cr), Silver (Ag), Molybdenum (Mo), Boron (B), Lithium (Li), and Nickel (Ni) levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects. Methods: This prospective study will be included 50 women with idiopathic premature ovarian insufficiency and 50 controls. The blood/urine/hair for analyses will be obtained at the early follicular phase of the menstrual cycle and plasma Lead (Pb), Cadmium (Cd), Gadolinium (Gd), Arsenic (As), Mercury (Hg), Cobalt (Co), Vanadium (V), Titanium (Ti), Sulfur (S), Chromium (Cr), Silver (Ag), Molybdenum (Mo), Boron (B), Lithium (Li), and Nickel (Ni) levels will be measured using inductively coupled plasma-mass spectrometry.

NCT ID: NCT04675970 Active, not recruiting - Clinical trials for Premature Ovarian Failure

Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

UB-OVF
Start date: September 1, 2020
Phase:
Study type: Observational

This is a multi-centers of long term safety and efficacy follow up study for patients with premature ovarian failure (the women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility) who have been treated with ex vivo gene therapy drug product in Institute of Bio-Stem Cell Rehabilitation UAB - sponsored clinical studies. After completing the parent clinical study (approximately 6 month), eligible subject will be followed for additional 2 years for total of 2 years and 6 month post drug product infusion. No investigation drug product will be administered in the study

NCT ID: NCT04641624 Completed - Clinical trials for Premature Ovarian Insufficiency

sFlt- 1, PIGF, and Niacin Levels in Women With Premature Ovarian Insufficiency

POI&niacin
Start date: November 20, 2020
Phase:
Study type: Observational

Aim: To evaluate serum soluble fms-like tyrosine kinase-1, proangiogenic protein placental growth factor, and niacin levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects. Methods: This prospective study will be included 45 women with idiopathic premature ovarian insufficiency and 45 controls. The blood for analysis will be obtained at the early follicular phase of the menstrual cycle and serum soluble fms-like tyrosine kinase-1, proangiogenic protein placental growth factor, and niacin levels will be measured using a commercially available ELISA kit.

NCT ID: NCT04536467 Enrolling by invitation - Clinical trials for Premature Ovarian Failure

Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patients

Start date: March 1, 2019
Phase: Phase 2
Study type: Interventional

To Prevent Chemotherapy Induced Ovarian Failure with the gonadotropin-releasing hormone Agonist Goserelin in Young female Lymphoma Cancer patients Receiving Chemotherapy

NCT ID: NCT04475744 Completed - Clinical trials for Premature Ovarian Insufficiency

4-step ASCOT in POI Women to Promote Follicular Rescue

Start date: March 5, 2021
Phase: Phase 3
Study type: Interventional

To promote follicular development in POI women, G-CSF mobilized activated platelet rich plasma will be directly injected into the ovarian medulla. This is a prospective, observational, multicentric, open, pilot-controlled randomized trial which seeks to evaluate the impact of the 4-step ASCOT technique on the ovarian reserve and reproductive outcomes of POI patients. The study will be developed in two phases. In a first step, POI women will randomized to control or undergo the 4-step ASCOT technique based on the direct ovarian injection of G-CSF mobilized and activated PRP. Follow up (AFC, AMH, FSH and E2 determinations) will be developed for 3 month in the controls and for 6 months in the treated and COS initiated if growing antral follicles detected. In the second phase, POI women allocated to control group after completed the follow up period will undergo the 4-step ASCOT technique, as described in the previous phase but only one ovary will be injected, then they will undergo a 6-month follow up period as described above.

NCT ID: NCT04439370 Recruiting - Hypertension Clinical Trials

Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Start date: October 1, 2019
Phase:
Study type: Observational

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.