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Menopause, Premature clinical trials

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NCT ID: NCT06302543 Recruiting - Clinical trials for Premature Ovarian Insufficiency

Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells

alfarah
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

investigator is doing single armed clinical interventional study to treat premature ovarian insufficiency with autologous bone marrow derived mononuclear cells to be given systematically and locally to the ovaries under ultrasound guidance with experienced gynecologist and to look for the results including: laboratory evidence through hormonal study ultrasound proof of ovarian follicle development. premature ovarian insufficiency is characterized by early loss of ovarian function (less than 40 years of age) manifested by menstrual irregularity or amenorrhea with elevated levels of gonadotropin hormones and low estrogen and anti-Mullerian hormone. Autologous use of stem cells from bone marrow are alternative safe minimal manipulative products that can provide a solution to this clinical problem without the need for oocyte donation program.

NCT ID: NCT06202547 Recruiting - Clinical trials for Premature Ovarian Failure

Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure

Start date: February 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Premature ovarian failure (POF) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. POF is characterized by menstrual disturbance (amenorrhea or oligomenorrhea) with raised gonadotrophins and low estradiol. The prevalence of POF is 1-2%. Extracellular vesicles (EVs) are membrane-packed vesicles that are secreted by a variety of cell types, including T cells, B cells, dendritic cells, platelets, mast cells, epithelial cells, endothelial cells, neuronal cells, cancerous cells, oligodendrocytes, Schwann cells, embryonic cells, and mesenchymal stromal cells-derived (MSCs). MSCs-EV more stable and induce stronger signaling and are produced in higher concentrations than stem cells. They demonstrate no inherent toxicity, are not associated with any long-term maldifferentiation of engrafted cells or tumor generation, and carry no apparent risk of aneuploidy or immune rejection following in vivo allogenic administration.Several studies have evaluated the safety and possible efficacy of injection MSCs-EV for the treatment of premature ovarian failure in animal models. Based on the available evidence, the study was designed with the aim of investigating the safety and effectiveness of intraovarian injection of MSCs-EV in patients with POF diagnosis.

NCT ID: NCT06167135 Recruiting - Obesity Clinical Trials

Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort

POMODORI
Start date: September 10, 2021
Phase:
Study type: Observational [Patient Registry]

Enrolling of 150 female patients of fertile age diagnosed with PCOS, insulin resistance, infertility, or mitochondrial disease, and the same number of age- and sex-matched controls are planned. During the research biomarkers already with mitochondrial dysfunction in the scientific literature and common mtDNA abnormalities (deletions, point mutations, copy number changes, etc.) are examined.

NCT ID: NCT06145061 Recruiting - Clinical trials for Premature Ovarian Insufficiency

Evaluation on Biological Characteristics of Acupoints in Premature Ovarian Insufficiency

Start date: March 1, 2023
Phase:
Study type: Observational

Acupuncture has been widely used in the treatment of Premature Ovarian Insufficiency(POI), but the selection of acupoints is indeterminate and lacks biological basis.In recent years,some studies suggested the "acupoint sensitization",that is,changes such as pain sensitivity and heat sensitivity appear on the acupoints under disease state.The biological characteristics of acupoints can reflect the state of local tissue and might be a potential factor for guiding acupoint selection. This study aims to compare the temperature and pain threshold of acupoints between POI patients and the healthy population.At the meantime,clinical diagnosis of POI is based on clinical symptoms and Follicle Stimulating Hormone (FSH).However,FSH fluctuates so much that prediction accuracy is not high and clinical application is limited.Therefore, given the lack of proper diagnostic accuracy in POI and the concept of "acupoint sensitization",it is necessary to summarize the changes of biological characteristics of related acupoints under physiological and pathological conditions as an auxiliary means to improve the diagnostic rate of POI.

NCT ID: NCT06121388 Recruiting - Clinical trials for Premature Ovarian Failure

Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian Failure

Start date: January 1, 2023
Phase:
Study type: Observational

The purpose of this study is to investigate the brain MRI imaging changes and associated factors on cognition function in patients with premature ovarian failure.

NCT ID: NCT06117982 Recruiting - Clinical trials for Premature Ovarian Failure

The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency

Start date: October 13, 2023
Phase: Phase 2
Study type: Interventional

The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: - Will treatment with G-CSF allow improvement in markers of ovarian reserve?

NCT ID: NCT06102655 Recruiting - Clinical trials for Traditional Chinese Medicine

Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics

JJGS and POI
Start date: July 24, 2023
Phase: Early Phase 1
Study type: Interventional

1. Identify differential metabolites in POI patients. 2. Analysis of differential metabolites and their involved mechanism pathways.

NCT ID: NCT06096766 Recruiting - Aging Clinical Trials

the Correlation Between Ovarian Function and Serum Biomarkers

Start date: October 25, 2023
Phase:
Study type: Observational

The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.

NCT ID: NCT06072794 Recruiting - Clinical trials for Diminished Ovarian Reserve

A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)

VL-POI-01
Start date: October 6, 2023
Phase: Phase 1
Study type: Interventional

The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.

NCT ID: NCT05961371 Recruiting - Osteoporosis Clinical Trials

Strength Training for Osteoporosis Prevention During Early Menopause

STOP-EM
Start date: November 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females. The main question it aims to answer are: -Is a 9-month resistance training intervention feasible (e.g., recruitment rates, protocol adherence, attrition) Secondary aims include examining changes in bone health, muscle strength, and menopausal symptoms. Participants will participate in a 9-month progressive, supervised, resistance training intervention. Researchers will compare secondary outcomes between the exercise group and a wait-list control group.