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Menopause, Premature clinical trials

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NCT ID: NCT04071574 Completed - Clinical trials for Polycystic Ovary Syndrome

Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility

CS-EOSP-ICSI
Start date: February 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A" gonadotropins alone, "B" short GnRH agonist, "C" multiple-dose GnRH antagonist, "D" long GnRH agonist and "E" combined protocol of GnRH antagonist and agonist) and the outcomes of ICSI. This comparative study will help clinicians to select the relevant protocol of ovarian stimulation related to the female infertility disorders.

NCT ID: NCT04031456 Recruiting - Clinical trials for Premature Ovarian Failure

Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients

PRP
Start date: July 30, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.

NCT ID: NCT04009473 Enrolling by invitation - Menopause Clinical Trials

Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation

SEGOVA
Start date: June 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.

NCT ID: NCT03985462 Withdrawn - Clinical trials for Stem Cell Transplant Complications

Very Small Embryonic-like Stem Cells for Ovary

Start date: July 3, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to premature ovarian failure.

NCT ID: NCT03924648 Completed - Clinical trials for Premature Ovarian Failure

Endocan Levels in Women With Premature Ovarian Insufficiency

Endocan&POI
Start date: July 1, 2018
Phase:
Study type: Observational [Patient Registry]

Objective: To evaluate serum endocan levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects. Methods: This prospective study included 38 women with idiopathic POI and 39 controls. The blood for analysis was obtained at the early follicular phase of the menstrual cycle and serum endocan levels were measured using a commercially available ELISA kit. Follicle-stimulating hormone (FSH), estradiol, and anti-mullerian hormone (AMH) were measured at the same time. The continuous values were evaluated using Student's t-test, and categorical values were evaluated using the Chi-square test. P values < .05 were accepted as significant.

NCT ID: NCT03877471 Active, not recruiting - Clinical trials for Primary Ovarian Insufficiency

Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency

MSCLCTWPOI
Start date: April 3, 2019
Phase: Phase 1
Study type: Interventional

There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI. Cell therapy is a rapidly developing field and have shown immense promise in the treatment of ovarian dysfunction. In this study, the investigator will evaluate the safety of MSC-like cell therapy in women suffering from POI.

NCT ID: NCT03861715 Recruiting - Infertility Clinical Trials

Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.

Start date: January 2017
Phase:
Study type: Observational

A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in oocyte donors.

NCT ID: NCT03840824 Completed - Clinical trials for Premature Ovarian Failure

Blood Spot Self-administered Test and Assay

Start date: October 2010
Phase:
Study type: Observational

The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.

NCT ID: NCT03816852 Suspended - Clinical trials for Premature Ovarian Failure

The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

Evaluate the safety of human umbilical cord mesenchymal stem cells (hucMSCs) in POI treatment; Evaluate the effective hucMSCs in POI treatment. Compare different infusion mode, meanwhile compare with hormone replacement therapy (HRT) withdrawal, so that assessing the stem cell therapy.

NCT ID: NCT03692572 Completed - Menopause Clinical Trials

Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause. This increased risk may be due to a prolonged length of time with decreased hormone levels post-menopause; however, this health risk remains understudied. The current study plan to study why women with early menopause are at higher risk for cardiovascular disease by evaluating their sympathetic nervous system and heart-blood vessel function. In addition, there is lack of promising treatment plans for cardiovascular disease in post-menopausal women. Therefore, the current study will also test the impact of dietary nitrate on post-menopausal women to determine if it might serve as a potential treatment to reduce risk of cardiovascular disease in older women.