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Infertility clinical trials

View clinical trials related to Infertility.

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NCT ID: NCT04924309 Not yet recruiting - Infertility, Male Clinical Trials

Stress in Couples Undergoing Assisted Reproduction Technology With Donor Sperm and Its Impact on Pregnancy Outcomes

Start date: June 20, 2021
Phase:
Study type: Observational [Patient Registry]

Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients.The purpose of this study is to investigate the stress faced by couples undergoing assisted reproduction with donor sperm and to further investigate its impact on pregnancy outcomes.

NCT ID: NCT04917445 Not yet recruiting - Infertility Clinical Trials

The Impact of the SPIKES Protocol With IVF Patients

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if the utilization of the SPIKES protocol for delivering bad news is perceived to be more compassionate and effective than the current standard of care for IVF patients receiving negative pregnancy test results.

NCT ID: NCT04908774 Recruiting - Fertility Disorders Clinical Trials

Effects of a Fasting Mimicking Diet on Sperm Quality

KiWu-B
Start date: May 25, 2021
Phase: N/A
Study type: Interventional

This study investigates the effect of repetitive cycles of a Fasting Mimicking Diet (3x5 days in six months) on sperm quality in men

NCT ID: NCT04905771 Recruiting - Infertility, Female Clinical Trials

Characterizing Follicles From Auto-transplanted Ovarian Tissue

Start date: February 1, 2021
Phase:
Study type: Observational

The aim of the project is to characterize the hormonal conditions in egg follicles in women who, prior to fertility treatment, have had autotransplanted frozen ovarian tissue for the purpose of fertility preservation.

NCT ID: NCT04904263 Recruiting - Cancer Clinical Trials

Advisory Board on Cancer, Infertility and Pregnancy

ABCIP
Start date: May 22, 2021
Phase:
Study type: Observational

The Advisory Board on Cancer, Infertility and Pregnancy provides a platform where physicians from all over the world can request recommendations regarding the medical care of pregnant women diagnosed with cancer or regarding fertility preservation. The platform will contain different national advisory boards, with their own coordinator and members, as well as an overarching international advisory board with an international coordinator and members from different national boards. To investigate the impact of this platform, a year after its launch, data regarding the incoming requests will be extracted from the website, as well as all recommendation letters.

NCT ID: NCT04902131 Not yet recruiting - Infertility, Female Clinical Trials

A Study Comparing MENOPUR in a Pen Formulation With a Powder and Solvent Formulation in Healthy Women

Start date: June 30, 2021
Phase: Phase 1
Study type: Interventional

MENOPUR is a human menotrophin product, with a combination of human follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. Human chorionic gonadotrophin (hCG) is the major contributor to the LH activity in the product. MENOPUR is approved in more than 130 countries for a variety of strengths and indications. In China, MENOPUR, 75 IU is approved for controlled ovarian hyperstimulation in relation to assisted reproductive technology (ART). The current trial is intended for supporting marketing authorization approval of a new formulation of MENOPUR in China. MENOPUR is currently available in China as a powder and solvent for solution for injection, containing 75 IU of FSH and 75 IU of LH activity. A new liquid formulation is developed by Ferring Pharmaceuticals for administration with a disposable pre-filled injection pen, containing 600 IU of FSH and 600 IU of LH activity. MENOPUR solution for injection in pre-filled pen, 600 IU/0.96 mL is the test product and MENOPUR powder and solvent for solution for injection, 75 IU is the reference product in this trial.

NCT ID: NCT04901247 Not yet recruiting - Infertility Clinical Trials

Exploring Single Step Culture Medium Refreshment Effect on Embryo Ploidy Rate

Start date: June 20, 2021
Phase:
Study type: Observational [Patient Registry]

While numerous types of commercially available human embryo culture media exist for human blastocyst culture, the impact of culture conditions on blastocyst development and aneuploidy formation is not fully understood. Culture conditions are very important for the success of the in vitro fertilization (IVF) cycle, many of the factors involved in the process have been extensively studied. However, none of the studies investigated the effect on euploid rate in a sibling oocyte design with preimplantation genetic testing for aneuploidy (PGT-A), which requires culture till day 7. In addition, the clinical outcome (implantation) will be investigated in a frozen cycle regimen. Hence, the study will explore which day of media refreshment will result in higher rate of ploidy and would improve clinical outcomes. Investigators aim at exploring the best practice, that would empower the euploid rate through the comparison of refreshing the single-step medium on day 3 or day 5 in a sibling oocyte prospective design.

NCT ID: NCT04888091 Not yet recruiting - Infertility Clinical Trials

This is a Randomised Control Study Comparing the Effect of Cervical Mucus Removal With Cotton Swab or Cannula on Pregnancy Rates Before Embryo Transfer.

Start date: May 20, 2021
Phase: N/A
Study type: Interventional

To assess the impact of cervical mucus cleansing before embryo transfer and compare two different instruments for this purpose.

NCT ID: NCT04880590 Recruiting - Infertility, Female Clinical Trials

Sex or no Sex: That is the Question.

Start date: May 4, 2021
Phase:
Study type: Observational

This study aims to evaluate the impact of sexual intercourse and orgasm in the 72 hrs following embryo transfer of blastocysts on the clinical pregnancy rate. An impact on sexual activity and a decrease in the frequency of intercourse has been observed in infertile couples. In couples who undergo assisted reproductive technology (ART), sexual relations have an additional component that can condition them, such as the fear of influencing the outcome of the cycle. The usual practice in ART cycles has evolved towards a preference for blastocyst-stage embryo transfer, both in fresh in vitro fertilization (IVF) cycles and in frozen embryo transfer (FET) cycles. The investigators consider it important to elucidate whether coital intercourse after embryo transfer (ET) has an impact on the clinical pregnancy rate after the transfer of blastocyst-stage embryos.

NCT ID: NCT04878991 Recruiting - Infertility, Female Clinical Trials

Metabolomics Embryo Selection Prospective Study

Start date: May 5, 2021
Phase: N/A
Study type: Interventional

In this study, we will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening. Metabolomics is a new, non-invasive method of embryo selection which involves testing discarded embryo culture media for analytes secreted by the developing embryo. These analytes can be used to determine the implantation potential, and ploidy, of the embryo. Study patients will be randomized 2:1 into control and treatment groups, respectively. The control group will have the best blastocyst selected for transfer based on morphological assessment alone (standard of care). The treatment group will have the best blastocyst selected for transfer based on metabolomics (experimental test) and morphology together. The primary endpoint will be ongoing pregnancy rates, comparing treatment and control groups. The secondary endpoint will be the Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of metabolomics. The result of the metabolomic analysis of culture media coming from embryos in the control group will be used to compare the clinical outcome (ongoing pregnancy) to the test's prediction and calculate PPV and NPV.