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Clinical Trial Summary

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).


Clinical Trial Description

Our long-term goal is to evaluate the transition from acute to chronic pain that sometimes occurs following CXL in keratoconus patients. This study will determine whether these changes can be structurally and functionally quantified using functional neuroimaging and in vivo corneal microscopy (IVCM), and whether they can be predicted based on predisposing biological and psychological factors. Our central hypothesis is that CXL produces acute pain through activation of trigeminal afferents, and that post-operative chronic pain outcomes are related to neuroplastic changes in trigeminal circuitry, corneal afferent regeneration, and psychological factors. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04439552
Study type Observational
Source Boston Children's Hospital
Contact Eric A Moulton, OD PhD
Phone 617-919-6827
Email eric.moulton@childrens.harvard.edu
Status Recruiting
Phase
Start date October 4, 2021
Completion date December 2025

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