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Wounds and Injuries clinical trials

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NCT ID: NCT05389059 Enrolling by invitation - Gingival Diseases Clinical Trials

Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.

Start date: April 25, 2022
Phase: N/A
Study type: Interventional

This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.

NCT ID: NCT05388591 Not yet recruiting - Wounds Injuries Clinical Trials

Evaluation of Musicotherapy on Pain During Wound Closure in the Emergency Department : a Randomized Controlled Trial.

EMERGENCE
Start date: June 2022
Phase: N/A
Study type: Interventional

To evaluate the effectiveness of music listening (with a musicotherapy application Music Care) on patients pain associated with care during wound suturing in the Adults emergency unit.

NCT ID: NCT05387811 Not yet recruiting - Acute Kidney Injury Clinical Trials

International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project

GLOBAL-AKI
Start date: June 15, 2022
Phase:
Study type: Observational [Patient Registry]

The aims of this study will be to identify the clinical characteristics, the management and the outcomes of acute kidney injury in patients with cirrhosis worldwide. Specific aims: 1. To establish the severity of AKI across different regions 2. To identify precipitants of AKI across different centers 3. To identify the phenotypes of AKI across different centers 4. To evaluate differences in the management of AKI across different centers and their impact on clinical outcomes 5. To assess outcomes of acute kidney injury (resolution of AKI, in-hospital mortality, 28-day mortality, 90-day mortality)

NCT ID: NCT05387018 Recruiting - Clinical trials for Traumatic Brain Injury

the Effects of Hyperbaric Oxygen on Non-acute Traumatic Brain Injury

Start date: March 23, 2022
Phase:
Study type: Observational

Traumatic brain injury (TBI) continues to be a major cause of death and disability throughout the world. The reduced cerebral blood flow secondary to the direct trauma-induced damage deregulates cerebral metabolism and depletes energy stores within the brain. Diffusion barriers to the cellular delivery of oxygen develop and persist. Besides, TBI often leads to intracranial hypertension, which in turn exacerbates diffusion disorders, further reducing cerebral oxygenation, and deteriorates the injury. By increasing the partial pressure of oxygen in blood, reducing intracranial pressure and cerebral edema, Hyperbaric oxygen therapy (HBO2) has been used in early treatment of TBI. However, due to the different severity of TBI, the clinical situation of early insult is complex and unpredictable, ordinarily there was a time delay between TBI and onset of HBO2 treatment averaging more than 2 weeks, especially in patients with severe TBI. Whether the delayed intervention is still effective is controversial.

NCT ID: NCT05386966 Not yet recruiting - Head Trauma Clinical Trials

Medicolegal Aspects of Head Trauma

Start date: July 2022
Phase:
Study type: Observational

Trauma is a critical global health problem. It represents the fifth leading cause of significant disability and is one of the most common causes of mortality in youth and adulthood, as one in 10 deaths worldwide occurred due to trauma. The head is preferred target for criminal acts and is a favorite place for various pathological lesions .Traumatic head injury (THI)is one of the prevalent causes of global death and disability. lately, head injury (HI) cases have increased in both developed and developing nations. Therefore, it is of great value to evaluate the clinical and pathological features of head injury . Every injury that results in harm to the scalp, skull or brain can be sort out as a HI which can be caused by traffic mishap, falls, sports and gunshot wounds. Vehicle accidents are one of the most prevalence causes of THI as they are deemed to be one of the main causes of fatality due to road-traffic accidents (RTA) .Among different type of the RTA, motorcycle accidents holds the number one cause of accident in most of the country . Skull fracture and hemorrhage are common association, which may be present with head trauma and affect the outcome of the case.The skull fractures, especially by blunt force offer varying diagnostic and medico- legal problems to the medical jurists as well as to the clinicians.

NCT ID: NCT05381493 Completed - Acute Kidney Injury Clinical Trials

Incidence and Outcomes of Acute Kidney Injury in Trauma Patients Admitted to Critical Care

Start date: January 1, 2021
Phase:
Study type: Observational

Acute kidney injury (AKI) is a common complication that increases lenght of stay and mortality in trauma patients admitted to the intensive care unit (ICU). The aim of this study is to identify the incidence and outcomes of trauma patients, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria, at single center level 3 ICU.

NCT ID: NCT05378997 Recruiting - Wound of Skin Clinical Trials

Safety, Tolerability, and Pharmacokinetics of Ascending Topical Doses of TCP-25 Applied to Epidermal Suction Blister Wounds

Start date: April 7, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase I, double-blind, placebo-controlled, randomized first-in-human study including healthy volunteers with acute epidermal wounds formed by the suction blister technique designed to evaluate the safety, tolerability, and potential systemic exposure of multiple topical doses of TCP-25.

NCT ID: NCT05376462 Recruiting - Trauma Clinical Trials

Quantra® System With the QStat® Cartridge in Trauma

Start date: April 12, 2022
Phase: N/A
Study type: Interventional

This is a prospective, single-center, controlled, open label, trial randomized in two parallel groups designed to assess the Quantra QStat System in trauma patients.

NCT ID: NCT05376449 Recruiting - Clinical trials for Spinal Cord Injuries

Spinal Cord Injury - Exercise

Start date: May 9, 2022
Phase: N/A
Study type: Interventional

Long lasting inflammation in the body is related to cardiovascular and respiratory disease, which are the two most common causes of death in people living with spinal cord injury (SCI). Individuals with SCI have been reported to have higher levels of inflammation when compared to healthy individuals. Exercise is a well-known method to reduce inflammation; however, people with SCI are often inactive. The main goal of this study is to determine whether a 12-week adaptive exercise program can reduce inflammation in people with SCI. Participants will be randomized to start exercise immediately or after a 12-week delay.

NCT ID: NCT05370729 Not yet recruiting - Myocardial Injury Clinical Trials

Impact of N-acetylcysteine Infusion and Intralipid Infusion on Myocardial Injury in Aluminum Phosphide Toxicity

Start date: May 2022
Phase: N/A
Study type: Interventional

Assess impact of ILE and NAC in morbidity and mortality when used as adjuvant therapy to routine management of acute ALP poisoning.