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Insulin Resistance clinical trials

View clinical trials related to Insulin Resistance.

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NCT ID: NCT03196154 Completed - Clinical trials for Diabetes Mellitus, Type 2

Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics

InsuReB
Start date: August 1, 2017
Phase:
Study type: Observational

Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced. Insulin resistance and beta cell function will be estimated through a mathematical model, homeostasis model assessment. Fasting insulin and C-peptide will be measured using liquid chromatography tandem mass spectrometry. Insulin resistance and beta cell function is then compared with the glycaemic control, HbA1C.

NCT ID: NCT03193125 Completed - Obesity Clinical Trials

Carnitine and Liver Mitochondria Fatty Acid Processing

Start date: May 15, 2017
Phase: N/A
Study type: Interventional

This double-blind, placebo-controlled randomized trial will assess whether 14 days of oral carnitine supplementation modifies mitochondrial fatty acid processing in healthy young adults.

NCT ID: NCT03189511 Completed - Insulin Resistance Clinical Trials

Effect of Fluvastatin on Brown Fat Activity

FluvaBAT
Start date: May 31, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.

NCT ID: NCT03189121 Completed - Obesity Clinical Trials

Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

Start date: November 20, 2017
Phase:
Study type: Observational

Background: Increases in obesity, diabetes, and some metabolic disorders may be linked to how much processed foods people eat. Researchers want to learn more about how processed foods affect metabolic health. Objective: To learn about how a processed versus unprocessed diet affects the body. Eligibility: Men ages 18-50 with stable weight and risk factors for diabetes Design: Participants will be screened over 3 visits. Screening includes: - Medical history and physical exam - Heart and blood tests - Psychiatric questions - Questions about eating, sleeping, and economic status - Riding a stationary bike - Trying a sample meal Between screenings, participants will eat prepared meals. They will wear an accelerometer to measure physical activity. They will write down what foods they eat and monitor their weight. Participants will have two 4-week stays in the clinic. They will: - Eat a special diet - Have activity and weight monitored - Drink water and collect urine samples to measure how many calories they are burning - Have resting energy expenditure measured with a clear hood over the head - Have a scan to measure body fat and bone density using low-dose x-rays - Have a scan on a table that slides into a metal cylinder in a strong magnetic field. They will get earplugs for the loud noises. - Have an ultrasound test to measure blood vessels - Have insulin and glucose infused into an arm vein. Blood will be taken over 10 hours through a plastic tube in the wrist. This will happen 4 times. - Spend multiple 24-hour periods in a room that measures oxygen used and carbon dioxide produced. - Give blood, urine and stool samples - Answer questionnaires and do computer tasks

NCT ID: NCT03185676 Completed - Insulin Resistance Clinical Trials

Efficacy of a Bilberry-based Probiotic Product on Glucose Tolerance and Insulin Resistance

Start date: May 2, 2017
Phase: N/A
Study type: Interventional

The impact of a bilberry-based probiotic drink on the postprandial levels of serum glucose and insulin have already been study in the past. The aim of the current study is to evaluate the long term effect of the probiotic bilberry drink on glucose tolerance and insulin resistance in healthy adults and in comparison to a control drink.

NCT ID: NCT03183752 Completed - Insulin Resistance Clinical Trials

Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules

Start date: August 13, 2015
Phase: N/A
Study type: Interventional

It has been shown that insulin might be involved in the pathogenesis of thyroid growth. Objective To evaluate the impact of IR and metformin use on the volume of benign thyroid nodules (TNs). Methods A randomized clinical trial to placebo (P) or MTF use. Previous fine needle aspiration confirming the diagnosis is necessary to inclusion. Patients will receive similar tablets of MTF and placebo and instruct to take 3 tablets/day of MTF (500mg/tablet). Thyroid volume, as TN volume, will be assess by ultrasound, both in the beginning, six months and one year after randomization, by the same researcher blinded regarding location group. Blood samples to measure: TSH, FT4, TPO-Ab, lipid profile, glucose and insulin were done after 8h fasting.

NCT ID: NCT03178396 Completed - Healthy Clinical Trials

Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets

Start date: December 7, 2015
Phase: N/A
Study type: Interventional

The investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.

NCT ID: NCT03167996 Completed - Hypertension Clinical Trials

Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology

HealthPals
Start date: June 23, 2016
Phase: N/A
Study type: Interventional

This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects them to their own doctors, nurses, and dietitians.

NCT ID: NCT03159065 Completed - Clinical trials for Postprandial Hyperglycemia

Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance

Start date: September 2014
Phase: N/A
Study type: Interventional

Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being. It has previously been observed that consumption of a bilberry drink decreases the postprandial insulin demand. In the present study, the impact of probiotic fruit beverages with different polyphenol profiles on the postprandial levels of glucose and insulin, were investigated.

NCT ID: NCT03146286 Completed - Insulin Resistance Clinical Trials

Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions

Start date: August 1, 2015
Phase: N/A
Study type: Interventional

The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.