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Insulin Resistance clinical trials

View clinical trials related to Insulin Resistance.

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NCT ID: NCT03841786 Completed - Clinical trials for Cardiovascular Diseases

Effect of Phosphorus Additives on the Metabolome in Healthy Adults

Start date: June 28, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effect of phosphorus supplementation on the human metabolome. The investigators will do so by conducting a cross-over study in healthy adults consuming a study diet (normal diet supplemented by neutral sodium phosphorus, 1 gram/day) for seven days and a control diet (normal diet supplemented by sodium and potassium chloride only) for seven days with a 28 day wash-out period in between. Untargeted metabolomic analyses will be done in serum samples obtained at the end of each diet period.

NCT ID: NCT03832790 Completed - Sleep Clinical Trials

Sleep, Glycemic Control, and Insulin Resistance in Adolescents With Type 1 Diabetes

SunDIAL
Start date: December 4, 2019
Phase:
Study type: Observational

Despite advancements in care, most adolescents with T1D have higher BMI and significantly higher HbA1c than recommended and are markedly IR, placing them at increased risk for CVD1,2. Thus, alternative approaches to improve and maintain glycemic control, IR, and BMI for adolescents with T1D are urgently needed. This proposal moves beyond the current insulin and carbohydrate counting-focused lifestyle change paradigm to focus on sleep and circadian misalignment, which will allow for identification of new mechanisms that can be directly translated into future intervention and prevention trials. The goal of the current study is to utilize multiple objective measures of sleep duration, timing (actigraphy), and circadian rhythm (melatonin) in adolescents with type 1 diabetes (T1D; N = 40) and examine relationships with glycemic control, IR, vascular health, and BMI. Further, qualitative methodology will be used to identify barriers and facilitators to healthy sleep in adolescents with T1D.

NCT ID: NCT03814512 Completed - Clinical trials for Diabetes Mellitus, Type 2

Improving Insulin Resistance and Energy Metabolism Through Sleep Extension in Adolescents

REM
Start date: March 21, 2019
Phase: N/A
Study type: Interventional

The investigators propose to deliver a 4-week sleep extension intervention to adolescents to evaluate feasibility of the protocol and obtain preliminary data on intra-individual changes in metabolic parameters induced by sleep extension.

NCT ID: NCT03809182 Completed - Insulin Resistance Clinical Trials

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Start date: September 27, 2012
Phase: Phase 4
Study type: Interventional

This study investigated the effect of dexmedetomidine in obese patients undergoing bariatric surgery.

NCT ID: NCT03800277 Completed - Metabolic Syndrome Clinical Trials

Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health

Phenulin
Start date: November 5, 2018
Phase: N/A
Study type: Interventional

The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity and associated metabolic health disorders. The gut microbiota compositions plays a decisive role in glucose metabolism and the chronic inflammatory state associated with insulin resistance. Consuming prebiotic rich diet, including polyphenol and inulin rich food could help modulate favorably the gut microbiota which could lead to a reduction of endotoxemia and beneficial metabolic health effects.

NCT ID: NCT03796286 Completed - Insulin Sensitivity Clinical Trials

A Randomized, Crossover Study to Assess the Effects of Dietary Fiber-containing Bars on Glucose and Insulin Responses

Start date: December 14, 2018
Phase: N/A
Study type: Interventional

This randomized, crossover study will include four clinic visits: one screening (day -7) and three test visits (days 0, 2, 4). The objective of this study is to assess the effects of dietary fiber-containing bars, at two doses of fiber, compared to a control product, on postprandial glucose and insulin responses in healthy adult men and women.

NCT ID: NCT03793036 Completed - Insulin Resistance Clinical Trials

Preoperative Administration of Oral Carbohydrate Drink and Postoperative Insulin Resistance

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This study compared traditional concept of preoperative fasting before elective open colon surgery and preoperative treatment with carbohydrate oral drink in intention to improve postoperative stress response to surgical procedure. Hypothesis was: preoperative oral carbohydrate drink reduces postoperative insulin resistance, improves insulin sensitivity, reduces postoperative inflammatory response in terms of the value of Glasgow Prognostic Score (GPS) and IL-6, improves postoperative patient's subjective well-being and surgical clinical outcome.

NCT ID: NCT03775902 Completed - Insulin Resistance Clinical Trials

Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development

Start date: December 19, 2018
Phase: N/A
Study type: Interventional

To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.

NCT ID: NCT03771417 Completed - Clinical trials for Cardiovascular Diseases

Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health

REALPA
Start date: January 16, 2019
Phase: N/A
Study type: Interventional

What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal cardiometabolic health in older adults?

NCT ID: NCT03771261 Completed - Obesity Clinical Trials

Balanced (Egg) Protein During Obesity Reduction: Differential Responses of Insulin Resistance by Race

EGGSPDITe
Start date: June 15, 2018
Phase: N/A
Study type: Interventional

The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (with substantial amounts provided from whole eggs and egg whites) with calorie restriction on insulin resistance and weight loss (along with function, body composition, racial disparities, and a number of secondary outcomes) in black and white older adults with prediabetes who are participating in a 4-month intervention. The investigators will compare these effects to the same outcomes with a control group consuming a traditional control regimen of calorie restriction over the same duration.