Hypertension Clinical Trial
To evaluate factors associated with cardiovascular morbidity and mortality in a cohort of 795 men and women aged 75 years or older at the time of a comprehensive examination conducted between 1984 and 1987.
BACKGROUND:
The study was needed because evidence in 1991 suggested that cardiovascular risk factors
which had been identified by studies of middle-aged populations did not have the same
predictive value in the elderly; especially the "oldest old" aged 75 and above.
DESIGN NARRATIVE:
The study analyzed data that had been collected over the years. At the time of the analysis,
mortality follow-up was complete for over 99 percent of subjects, and incident morbidity
information was available for myocardial infarction, coronary bypass surgery and stroke. The
database included measurements which allowed: 1) prospective analyses of the effects of
putative cardiovascular risk factors on disease incidence in the elderly, 2) prospective
analyses of the impact of change in risk factors on events in the elderly, 3) exploration of
risk factors not classically associated with cardiovascular events in younger populations
but which may be important in the very old, and, 4) cross-sectional description of putative
risk factors in an aged population.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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