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Hyperglycemia clinical trials

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NCT ID: NCT03624569 Recruiting - Clinical trials for Cardiovascular Diseases

Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome

Start date: August 15, 2018
Phase: N/A
Study type: Interventional

This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e. nondigestible carbohydrate), on blood vessel and gut health function in adults with metabolic syndrome. It is expected that the daily consumption of potatoes for two weeks, within a diet that follows the Dietary Guidelines for Americans, will improve blood vessel function in association with decreasing gut permeability ("leaky gut") that results in the absorption of bacterial toxins that reside in the intestine. Outcomes will therefore support dietary recommendations for potatoes to support vascular and gastrointestinal health.

NCT ID: NCT03593746 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Effects of High Intensity Interval Training and Combined Training in Type 2 Diabetic (T2D) Patients

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

Diabetes has become a widespread epidemic, primarily because of the increasing prevalence and incidence of type 2 diabetes (T2D). T2D is a significant cause of premature mortality and morbidity related to cardiovascular disease, blindness, kidney and nerve disease, and amputation. Physical activity improves blood glucose control and can prevent or delay T2D, along with positively affecting lipids, blood pressure, cardiovascular events, mortality, and quality of life. At present, although physical activity is a key element in the prevention and management of T2D, the most effective exercise strategy (intensity, duration, and type of exercise) for improving glucose control and reducing cardiometabolic risk in type 2 diabetes has not been defined. Studies with Light-Emitting Diode (LED) therapy have demonstrated its ability to promote pain relief, improve muscle and cardiopulmonary performance, minimize muscle fatigue, and stimulate wound healing. In relation to patients with T2D, who have prolonged conditions of hyperglycemia, studies to investigate the impact of photobiomodulation associated with physical training have not been found so far. The objective of this study is to investigate the effects of different types of physical training associated with Light-Emitting Diode (LED) therapy on cardiometabolic status and quality of life in patients with T2D.

NCT ID: NCT03422900 Recruiting - Stroke Clinical Trials

Hyperglycemia in Patients With Stroke and Indication of Enteral Nutrition

GlyENStroke
Start date: December 12, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of a specific nutritional formula for diabetics on the development of hyperglycemia in patients with recent non-diabetic stroke who require admission and enteral nutritional support by nasogastric tube. As well as the effect on metabolic control, development of comorbidities, hospital stay, readmissions, mortality and tolerance of the formula under study.

NCT ID: NCT03404180 Recruiting - Hypertension Clinical Trials

Peripheral Nerve Blocks for Above-the-knee Amputations

Start date: February 9, 2018
Phase: Phase 4
Study type: Interventional

Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral vascular disease, diabetes, hypertension, coronary artery disease, and chronic obstructive pulmonary disease (COPD).

NCT ID: NCT03269799 Recruiting - Periodontitis Clinical Trials

Vitamin C as an Adjunct in Periodontal Treatment in Type 2 Diabetes Mellitus Patients

Start date: August 30, 2017
Phase: Phase 2
Study type: Interventional

Periodontitis patients with uncontrolled type 2 diabetes mellitus will receive non-surgical periodontal treatment and then be supplemented with daily 500 mg vitamin C (test group) or placebo (control group) for 2 months. Clinical parameters will be retrieved at baseline, at the end of week 4 and at the end of week 8.

NCT ID: NCT03255876 Recruiting - Healthy Clinical Trials

Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects

PolyGlucHeal
Start date: April 10, 2017
Phase: N/A
Study type: Interventional

Results from a large number of studies in humans have shown that diets rich in foods that give lower glucose response bring lower risk of type 2 diabetes. Polyphenols, naturally found in fruits, vegetables and grains, have shown the potential to attenuate post-prandial blood glucose spikes following a carbohydrate-rich meal, through partial inhibition of the main enzymes of carbohydrate digestion and reduction in glucose and fructose transport from the gut after digestion and by enhancing the insulin action after glucose reaches the bloodstream. This study is designed to determine whether polyphenols, as normally and naturally present in food extracts and beverages, added to a carbohydrate-rich meal, can lower blood glucose levels after its consumption, and hence lower its glycaemic index, and if this effect is mediated through effects on insulin and other hormones. The study is designed as an acute, double-blind, randomised, placebo-controlled crossover trial in 24 healthy subjects with normal glycaemic response to white bread. Participants will be asked to consume either white bread with pomegranate juice enriched with extracts from grape seeds and apple peels or white bread with placebo drink. The effects on plasma glucose levels, levels of hormones and other biomarkers involved in postprandial response will be determined over 3 hours after the consumption.

NCT ID: NCT03152890 Recruiting - Clinical trials for Liver Transplantation

Insulin Therapy for Postreperfusion Hyperglycemia

INS_LTPL
Start date: May 15, 2017
Phase: Phase 4
Study type: Interventional

Glycemic control during liver transplantation is challenging especially after reperfusion of the liver graft. Insulin dose to treat postreperfusion hyperglycemia is retrospectively analyzed using historical data. The proposed dose then is prospectively applied to the patients to assess the adequacy of the insulin dose.

NCT ID: NCT03087032 Recruiting - Clinical trials for Overweight and Obesity

Liraglutide-bolus vs Glargine-bolus Therapy in Overweight/Obese Type 2 Diabetes Patients (LiraGooD)

LiraGooD
Start date: January 10, 2019
Phase: Phase 4
Study type: Interventional

The present 24-week, prospective, open-label, randomized, multicenter, parallel group trial is carried to investigate and evaluate the efficacy and safety of Liraglutide in combination with prandial insulin therapy vs insulin glargine in combination with prandial insulin therapy in overweight / obese patients with uncontrolled type 2 diabetes.

NCT ID: NCT03062072 Recruiting - Breast Cancer Clinical Trials

Emergence of Chemotherapy Related Hyperglycemia in nOn-diabetic Patients

ECHO
Start date: April 2015
Phase: N/A
Study type: Observational

To assess chemotherapy related hyperglycemia in non-diabetic patients, the investigators will assess the incidence of hyperglycemia and analyze co-medications and risk factors.

NCT ID: NCT03057470 Recruiting - Clinical trials for Diabetes Mellitus, Type 1

Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT)

FIT
Start date: May 2016
Phase: Phase 4
Study type: Interventional

The overall objective of this study is to investigate the glycemic response of a 0%, 50%, 100% and 150% bolus insulin correction (based on personal insulin correction factor) of post-exercise hyperglycemia in physically active adults with type 1 diabetes (T1D) using multiple daily injections (MDI) in a controlled, but clinically representative, experimental setting.