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HIV Infections clinical trials

View clinical trials related to HIV Infections.

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NCT ID: NCT04973267 Recruiting - Clinical trials for Alcohol; Harmful Use

Game Plan for PrEP

Start date: July 1, 2021
Phase: Early Phase 1
Study type: Interventional

This small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (PrEP) moderate their alcohol use, and improve key outcomes of PrEP care, including adherence, persistence, and STI rates. Men with a history of "lapses" in PrEP adherence will be randomly assigned to either (1) use the web-based intervention, called Game Plan for PrEP, or (2) watch video clips encouraging healthy lifestyles (e.g., sleep hygiene, balanced diet; attention-matched control). Participants will complete STI testing and submit dried blood spot (DBS) samples to facilitate analyses of alcohol use and PrEP adherence biomarkers at baseline, 3-months, and 6-months during the study period. Participants will also complete online surveys at baseline, 1-month, 3-months, and 6-months during the study period.

NCT ID: NCT04973254 Not yet recruiting - HIV Infections Clinical Trials

Improving Treatment and Retention Adherence in Nontraditional Settings

I-TRAINS
Start date: August 2021
Phase: Phase 4
Study type: Interventional

I-TRAINS aims to integrate an injectable treatment that is approved for HIV to individuals outside of the standard doctors office or clinic. The treatment, a once a month injection, will be administered to participants in community partner spaces, reducing the barriers that having to present to a traditional clinic for treatment creates. Individuals who will receive the injection may have a history of being unable to take their HIV oral medication, as well as other barriers to care that make it difficult to engage in a traditional clinic setting. These barriers may include, but are not limited to, homelessness, substance use, mental illness, and stigma around their diagnosis. Data will be collected on whether it was easier for the participants to receive care in a non-traditional setting, as well as whether the injection made it easier for them to remain adherent to their HIV medication in comparison to standard oral HIV medication.

NCT ID: NCT04958122 Recruiting - Clinical trials for Human Immunodeficiency Virus

Cefixime Clinical Trial

Start date: June 20, 2021
Phase: Phase 3
Study type: Interventional

This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.

NCT ID: NCT04951544 Not yet recruiting - HIV/AIDS Clinical Trials

LetSync: Pilot Test of Mobile Health (mHealth) Intervention

Start date: September 2021
Phase: N/A
Study type: Interventional

The Pilot Test (AKA Study B) will entail a pilot randomized, controlled trial (RCT) of an mHealth behavioral intervention, LetSync, with 80 couples (N=160) to assess its acceptability, feasibility, and preliminary impact on retention in care and ART adherence as measured by antiretroviral concentrations in hair. Participants in the intervention arm will use LetSync v1.0 for 6 months and provide acceptability and feasibility data. In the ensuing 2 months, the investigators will make refinements based on participants' data to produce LetSync v2.0. Then, participants in the waitlist-control arm will receive LetSync v2.0, use it for 6 months, and provide acceptability and feasibility data. The intervention arm will continue using LetSync v1.0, for a total of 14 months. Based on acceptability and feasibility data from waitlist control arm participants between T3 and T4, the investigators will develop LetSync v3.0, which will be used for efficacy testing in a full RCT trial in the future.

NCT ID: NCT04950153 Recruiting - Clinical trials for Adolescent HIV Infection

Intensive Combination Approach to Rollback the Epidemic in Nigerian Adolescents: UH3 Phase

iCARE
Start date: April 15, 2021
Phase: N/A
Study type: Interventional

Combination interventions with mHealth and Peer Navigation components will be evaluated in a randomized, stepped wedge trial among youth in Ibadan, Lagos, Sagamu, and Jos, Nigeria. Study findings will demonstrate whether or not the combination interventions for HIV testing and linkage to care and for HIV treatment outcomes, which were found to be efficacious in our prior pilot UG3 trial, will remain efficacious if scaled as proposed in this UH3 trial, across multiple sites.

NCT ID: NCT04949464 Not yet recruiting - HIV Infection Clinical Trials

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.

NCT ID: NCT04947475 Recruiting - HIV Infections Clinical Trials

Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community

MATLINK
Start date: January 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy a Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for linking opioid dependent individuals currently incarcerated in Moldova, Kyrgyzstan, and Ukraine to opioid substitution therapy in the community after release.

NCT ID: NCT04944654 Not yet recruiting - Clinical trials for Human Immunodeficiency Virus

Efficacy, Tolerability and Acceptability of Biktarvy by TPLWH

Start date: October 2021
Phase: Phase 4
Study type: Interventional

This is a clinical trial for TPLWH (Trans People Living with HIV) who are stable on cART with an undetectable viral load or a detectable viral load but no resistance to NRTIs and InSTI. Following written consent and screening procedures, study subjects will undergo a switch (or will restart) of their combination antiretroviral therapy (cART) to Biktarvy. The goal of this research project is to recruit an understudied population into a controlled clinical trial aimed at optimizing TPLWH cART. This will be demonstrated by measuring viral load outcomes at regular intervals, with a focus on viral load results 48 weeks after Biktarvy initiation (primary outcome).

NCT ID: NCT04936594 Recruiting - HIV Clinical Trials

TMS for Smoking Cessation in PLWHA Cessation in People Living With HIV/AIDS (PLWHA)

Start date: May 24, 2021
Phase: N/A
Study type: Interventional

The pilot study proposal aims to modulate craving and attentional bias towards smoking cues in 40 people living with HIV/AIDS (PLWHA) using transcranial magnetic stimulation (TMS), with functional MRI (fMRI) brain correlates. TMS is a form of noninvasive brain stimulation and modulates neural activity using tiny doses of focused electricity. For the study, participants would perform two cognitive tasks and neuroimaging before and after the TMS and investigators would compare changes in these paradigms with TMS. The investigators will also get a point of contact urine drug screen before study initiation. The investigators will aim to recruit 20 subjects in each arm of our trial (total of 40) from the BlueGrass HIV Clinic.

NCT ID: NCT04930744 Not yet recruiting - Tuberculosis Clinical Trials

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)

METHOD
Start date: June 2021
Phase: Phase 2
Study type: Interventional

The METHOD study will examine whether adding metformin to standard antibiotic treatment for tuberculosis (TB) in people with HIV is safe and well tolerated. The study will also test if adding metformin clears the infection more quickly and with less lung damage. When enrolled, participants will have an equal chance of being in the group that takes standard TB medicines alone or in the group that also takes metformin. Participants will have a chance to be put on either: 1) standard TB medicines (isoniazid, rifampicin, ethambutol and pyrazinamide for two months, continuing isoniazid and rifampin for four more months) only; or 2) the same standard TB medicines plus metformin. Participants randomized to the metformin arm will take metformin for eleven weeks, starting one week after starting the standard TB medicines. In addition to monitoring for side effects, all participants will have studies of drug levels and lung and immune function.