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HIV Infections clinical trials

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NCT ID: NCT05085717 Not yet recruiting - HIV Infection Clinical Trials

Prevention, Access to Rights, Catch-up Vaccination, Treatment of Conditions During Pregnancy and for Children

PARTAGE
Start date: November 2021
Phase:
Study type: Observational

Insufficient screening and diagnostic delay play a significant role in sustaining the HIV epidemic by France. Gender inequalities major factors reinforce social inequalities in order to of heterosexual men born abroad the most later diagnosed with HIV infection. Those gender differences are largely due to efficiency antenatal HIV screening, offered to women every pregnancy and widely accepted: a billed HIV serology in the context of pregnancy monitoring was found for 92% pregnant women benefiting from health insurance in 2015 the health of men is not taken into account in prenatal follow-up current French. The maternity hospital drains a population largely immigrant, often precarious The male prenatal consultation exists but it is not organized: it is possible to implement it, provided that the constraints exerted on men are taken into account. the projet study the feasibility and the implementation processes place of prenatal consultation of future fathers

NCT ID: NCT05085171 Not yet recruiting - Clinical trials for The Study Will Focus on Assessing the Survival Benefit on an Enhanced Package of Care for Patients With Advanced HIV Disease

An Enhanced Package of Care to Reduce Reduce Mortality in Advanced HIV Disease

ENCORE
Start date: March 2022
Phase: Phase 3
Study type: Interventional

A community-based Phase III, cluster randomized trial that seeks to determine the 24 week survival with retention in care of point of care CD4 testing with visitect and an enhanced package of screening and prophylaxis for opportunistic infections among patients with advanced HIV disease.

NCT ID: NCT05085158 Not yet recruiting - HIV Infection Clinical Trials

Pathogen Detection in HIV-infected Children and Adolescents With Non-malarial Febrile Illnesses Using Metagenomic Next-generation Sequencing Approach

PHICAMS
Start date: June 1, 2022
Phase:
Study type: Observational

In Uganda, 130,000 children (0-14 years of age) were living with HIV in 2018. Last year, nearly 450 infants acquired HIV every day; most of them during childbirth and these are at extremely high risk of dying in the first two years of life from treatable infections which present with fever. While fevers are commonly attributed to malaria, most fevers in African children are not due to malaria and clinicians are challenged by the similar clinical features of wide spectrum of potential aetiologies. The prevalence of treatable causes of non-malarial febrile illnesses in children in Africa has been reported to be 45%.

NCT ID: NCT05083273 Recruiting - Virus-HIV Clinical Trials

Life Experience of People Aged 60 and Over Living With HIV

PVVIH
Start date: May 18, 2021
Phase:
Study type: Observational

The purpose of this study is to Assess the impact of HIV on the life course of patients aged 60 and over.

NCT ID: NCT05079451 Not yet recruiting - HIV Infections Clinical Trials

Broadly Neutralizing Antibodies 3BNC117-LS & 10-1074-LS to Prevent Relapse During ATI

Start date: November 1, 2021
Phase: Phase 1
Study type: Interventional

Participants will receive an infusion of both study drugs (3BNC117-LS and 10-1074-LS) and will discontinue antiretroviral therapy (which is the treatment for HIV) two days later. Participants will receive a second dose of the first study drug (3BNC117-LS) at week 12 if the HIV infection is maintained and participants remain off of antiretroviral therapy. The study hypothesizes that intravenous infusions (which means medication is delivered directly into a participant's vein) of the combination of study drugs will be safe and well tolerated, will maintain control of the HIV infection without antiretroviral therapy, and may be associated with a decrease in HIV found in cells that were previously infected with HIV but not actively producing HIV in the body.

NCT ID: NCT05079347 Not yet recruiting - HIV Infection Clinical Trials

Traditional Healer-initiated HIV Counseling and Testing in South Africa

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The objective of this proposal is to conduct a pilot test of a program aimed at training traditional healers to conduct HIV testing and implementing HIV testing among people living in Bushbuckridge, South Africa. Pilot Healer-initiated HIV testing uptake and linkage to prevention services. Trust in allopathic health care and HIV stigma will be measured among participants at study enrollment and at month seven. Hypothesis: Healer-initiated HIV counseling and testing (HICT) will increase trust in allopathic health care and reduce HIV stigma.

NCT ID: NCT05078957 Not yet recruiting - HIV Infections Clinical Trials

Microbiota Footprint and Frailty Phenotype in Virologically Suppressed People Living With HIV

FRAMIVIH
Start date: January 2022
Phase:
Study type: Observational

Analysis of gut microbiota becomes more and more accessible in recent years. Experimental data in both animal and human studies have demonstrated that imbalance of the gut microbiota which is called symbiosis may participate in an accelerated procedure of ageing as well as the expression of frailty phenotype. People living with HIV (PLHIV) present markers of phenotypic frailty on average 10 years before uninfected people. In this population structural and functional modifications of GALT (Gut Associated Lymphoid Tissue) are observed early after HIV infection and persist despite virological suppression on ART (AntiRetroviral Treatment). These GALT modifications are associated with microbial translocation that is also correlated with immune activation and dysbiosis. The objective of study is to explore gut microbiota of PLWH over 5 years, as well as to study associations of its longitudinal evolution with frailty markers and burden of comorbidities.

NCT ID: NCT05075967 Not yet recruiting - HIV Infections Clinical Trials

Getting to Zero Among Black MSM in the American South

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

HPTN 096 is a community-randomized, controlled, hybrid-type III implementation effectiveness study. It is designed to evaluate an integrated strategy approach to increase the uptake and use of pre-exposure prophylaxis (PrEP) and viral suppression rates among Black MSM in the southern United States. A status-neutral approach will be taken such that Black MSM, regardless of HIV status (both those living with and without HIV), will be included in the study.

NCT ID: NCT05075070 Recruiting - HIV Infections Clinical Trials

Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in People With HIV Infected

Start date: October 8, 2021
Phase: Phase 4
Study type: Interventional

Evaluation of immunogenicity and safety of the subjects infected with HIV to receive the schedule of two doses inactivated COVID-19 vaccine with the interval of 21 days .

NCT ID: NCT05075044 Recruiting - HIV Infections Clinical Trials

Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in People Aged ≥18 Years With HIV Infected

Start date: October 8, 2021
Phase: Phase 4
Study type: Interventional

Evaluation of immunogenicity and safety of the subjects aged 18 years and above with HIV-infected recruited to receive three doses of inactivated COVID-19 vaccine on day 0, day 21 and day 111, respectively .