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NCT ID: NCT02983643 Recruiting - Metabolic Syndrome Clinical Trials

Body Composition Changes During Stem Cell Transplantation: The Case Of Lymphoma Patients

Start date: January 2016
Phase: N/A
Study type: Observational

Skeletal Muscle Index (SMI) and Visceral Adipose Ratio (VAR) assess body composition changes and disclose malnutrition risk effectively. The aims of the study are to assess prevalence of malnutrition in patients planned for SCT, to characterize changes in body composition (SMI, total adipose tissue and VAR) that occur in the peri transplantation phase, and to identify Waist Circumference (WC) cut off points associated with the metabolic syndrome (MetSyn) in patients with B and T cell Lymphoma.

NCT ID: NCT02942303 Recruiting - Brow Lifting Clinical Trials

The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial

Start date: October 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to describe three safe and reproducible techniques for brow lifting using botulinum toxin. It will also describe the effect of 2 techniques on the eyebrow shape using quantitative, objective measurements and satisfaction scales.

NCT ID: NCT02932852 Recruiting - Keratoconus Clinical Trials

Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases

A-ADAS-CT-CD
Start date: November 2015
Phase: Phase 0
Study type: Interventional

Transplantation of cellularized human cornea impregnated and populated by mesenchymal stem cells derived from the patient's adipose tissue. The purpose of the study is to assess the safety, tolerability, and preliminary efficacy of transplantation of a single dose of autologous mesenchymal adipose tissue derived adult stem cells (ADAS) cellularized into laminas for subjects with corneal defects. 3 groups will be included in the study: (1) transplantation of ADAS alone without scaffold, (2) transplantation of scaffold (human corneal decellularized lamina) without ADAS, and (3) transplantation of ADAS cellularized on scaffold (the human corneal decellularized lamina)

NCT ID: NCT02847364 Recruiting - Ileus Clinical Trials

Effect of Chewing Gum on Post-operative Ileus (GUMPI)

GUMPI
Start date: February 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether chewing gum post-operatively decreases the time to first flatus or defecation in patients undergoing spine surgery as a indirect indicator of post-operative ileus.

NCT ID: NCT02837640 Recruiting - Clinical trials for Retinitis Pigmentosa

Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.

NCT ID: NCT02774057 Recruiting - Clinical trials for Inflammatory Bowel Disease

Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD

Start date: March 2016
Phase: Phase 4
Study type: Interventional

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflammation limited to the mucosal layer of the colon. Anemia is a consistent clinical feature of IBD. It is encountered in one third of IBD patients, and is the most common extraintestinal complication of this disease. Anemia has a significant impact on the quality of life of affected patients. Many patients with IBD frequently complain of chronic fatigue commonly caused by anemia and this may be as debilitating to patients as abdominal pain and diarrhea. Anemia in IBD is multifactorial, but is most commonly the result of iron deficiency anemia (IDA) and rarely due to anemia of chronic disease (ACD). Oral iron supplementation has been used traditionally for the treatment of IDA but studies have shown that it may result in disease exacerbation by increasing oxygen free radicals within the lumen of the gut via the Fenton reaction. A recent study done in University Hospitals Birmingham, United Kingdom, has shown that treatment with oral iron results in failure to control anemia in 2 out of 3 IBD patients, which is in part due to the side effects reported by over half of patients. Captafer is a new iron-free oral preparation that contains a special type of oligosaccharides from fish muscle tissue able to make the intestine absorb 3 to 5 times more iron in comparison to the "meat factor". Moreover, Captafer contains other vitamins and supplements that improve anemia.

NCT ID: NCT02762851 Recruiting - Heart Failure Clinical Trials

Influenza Vaccine To Prevent Adverse Vascular Events (RCT-IVVE)

RCT-IVVE
Start date: June 2016
Phase: Phase 4
Study type: Interventional

A multi-centre, randomized, placebo controlled, trial. Participants at high-risk for vascular events from the network of INTER- CHF will be randomized to inactivated influenza vaccine or placebo and followed prospectively over three influenza seasons. 5,000 participants will be enrolled prior to influenza season, randomized to either influenza vaccine or saline placebo, either of which they will receive annually for three years and then followed over each of the influenza seasons.

NCT ID: NCT02721862 Recruiting - Cholelithiasis Clinical Trials

Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy

Start date: March 2016
Phase: Phase 3
Study type: Interventional

This is a randomized double-blind placebo-controlled trial with a total of 100 patients who are free of gallstones at baseline. The study involves taking an oral drug (Ursodeoxycholic Acid 250mg) or a placebo twice daily for a period of six months and undergoing a total of three abdominal ultrasounds (at 6 months, at 12 months, and at 18 months) to check for gallstones.

NCT ID: NCT02706704 Recruiting - Uveitis Clinical Trials

Intravitreal Adalimumab Versus Subcutaneous Adalimumab in Non-infectious Uveitis

IVAS
Start date: February 2016
Phase: Phase 2
Study type: Interventional

The objective of this study is to compare and evaluate the efficacy of subcutaneous (40mg) adalimumab biweekly injections to intravitreal adalimumab (1.5 mg/ 0.03 mL) administration, given at zero, 2 weeks then every four weeks, in subjects with active non-infectious intermediate-, posterior-, or pan-uveitis.

NCT ID: NCT02587910 Recruiting - GERD Clinical Trials

Melanole, a Dietary Supplement, for the Treatment of Gastroesophageal Reflux Disease

GERDMeDS
Start date: October 2015
Phase: Phase 2/Phase 3
Study type: Interventional

Melanole, a Nigella sativa (Black Seed) extract , is studied for the treatment of GERD. Participants, who meet the inclusion criteria, will be divided into two arms. Arm 1: Subjects who meet criteria for GERD will undergo 24 hour pH monitoring. Arm 2: Subjects who meet criteria for GERD and who undergo only symptomatic monitoring of GERD on treatment. All participants will be evaluated before and after the administration of the study product.