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NCT ID: NCT05943457 Not yet recruiting - Arterial Stiffness Clinical Trials

Vitamin K2 Supplementation in Adult Episodic Migraine

ViKEM
Start date: September 2023
Phase: N/A
Study type: Interventional

Migraine is a debilitating illness and a major cause of disability in the world. It is highly prevalent, especially among women. Vitamin supplementation is a potential therapeutic option for migraines that remains largely under-explored. Several studies have shown that people with migraine tend to have higher arterial stiffness than people without migraine. Vitamin K2 deficiency is an important mediator of arterial stiffness and calcification due to decreased carboxylation of matrix Gla protein (MGP). Supplementation reverses these changes and improves vascular health in patients with end stage renal disease according to previous studies. Therefore, vitamin K2 supplementation could serve a potential role in migraine patients. The purpose of the study is to test the effect of vitamin K2 on decreasing the frequency of migraine attacks and decreasing arterial stiffness. The population will be recruited from the neurology clinic at LAU Medical Center-Rizk Hospital and will constitute of adult patients. They will be randomized to receive either the supplement of vitamin K2 or a placebo for the duration of 6 months. Laboratory tests and arterial stiffness measurements will be done at the beginning, middle, and at the end of the study for comparison.

NCT ID: NCT05847751 Not yet recruiting - Clinical trials for Severe Aortic Valve Stenosis

The Use of ACURATE Neo 2 Valve in Patients With Symptomatic Aortic Valve Stenosis

BSC07
Start date: January 2024
Phase:
Study type: Observational [Patient Registry]

The objective of this study is to evaluate the ACURATE Neo2 in the Middle East population with severe, symptomatic aortic stenosis.

NCT ID: NCT05729022 Not yet recruiting - Clinical trials for Radiculopathy Lumbar

Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid Injections

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the Microendoscopic combined with ultrasound technique to the standard routinely used X-ray guided transforaminal steroid injection technique.

NCT ID: NCT05628389 Not yet recruiting - Smoking Cessation Clinical Trials

Phone Enabled Implementation of Cessation Support (PHOENICS)

Start date: October 2023
Phase: N/A
Study type: Interventional

The tobacco use burden in Lebanon is exceptionally high: 35% of adults are current cigarette smokers and 39% are current waterpipe smokers. Although the World Health Organization endorses evidence-based interventions for population-level tobacco dependence treatment, recommended treatments are not integrated as a routine part of primary care in Lebanon, as is the case in other low-resource settings. The objective of this proposal is to evaluate the comparative effectiveness of promising multi-component interventions for implementing evidence-based cessation treatment in Lebanon's national system of primary health care centers.

NCT ID: NCT04813367 Not yet recruiting - Clinical trials for Twisted Fallopian Tube

Twisted Fallopian Tubes

Tubes
Start date: April 2021
Phase:
Study type: Observational

Isolated tubal torsion is a very rare event already in adults (1: 1.5 million women), it remains exceptional in children without being able to find a prevalence in the literature. The causes can be malformative or idiopathic, but even that remains unknown. Because of the scarcity, surgical treatment is not standardized and left to the good care of the surgeon in charge.

NCT ID: NCT04372043 Not yet recruiting - Sleep Hygiene Clinical Trials

Evaluation of the Sleep Hygiene in the Lebanese Population During the COVID-19 Confinement Period.

Start date: April 30, 2020
Phase:
Study type: Observational

The term "sleep hygiene" refers to a series of healthy sleep habits that can improve the ability to fall asleep. These habits are the most effective long-term treatment for people with chronic insomnia. The "Sleep Hygiene Index" is a 13-item questionnaire that evaluates these habits. We are in the process of validation of this questionnaire in the arabic language. We will evaluate these habits in the Lebanese population during the COVID-19 confinement period.

NCT ID: NCT03836638 Not yet recruiting - Aging Clinical Trials

The Impact of Age on Botulinum Toxin Potency in Facial Rhytides Treatment

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Botulinum toxin is approved by the FDA for the treatment of facial wrinkles. Patients are usually older than 45 years and their main demand is to treat pre-existing facial wrinkles. However with the increasing popularity of this technique, younger patients, aged 25 to 35 years, are now seeking botulinum toxin injection as a preventive measure for rhytides. The usual dose used for the treatment of facial rhytides in a female patient older than 45 years is 50 units. No consensus exists concerning the dose of botulinum toxin that should be used in younger patients. Hypothesis: lower dose of botulinum toxin is sufficient to give good and long lasting results in young patients. The objective of this randomized open-label study is to evaluate the effect of lower doses of Botulinum toxin on the facial rythides in young patients.

NCT ID: NCT03834935 Not yet recruiting - Pityriasis Alba Clinical Trials

Efficacy of Topical Pimecrolimus in the Treatment of Pityriasis Alba

Start date: March 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Pityriasis alba (PA) is a common benign skin disorder, that usually affects children and adolescents of darker phototypes. A history of atopic dermatitis is a well-known risk factor, and PA may be a minor manifestation of atopic dermatitis, although it can occur in nonatopic individuals as well. The objective is to evaluate the effect of topical pimecrolimus in the treatment of treatment of PA

NCT ID: NCT03186001 Not yet recruiting - Browlift Clinical Trials

Frontalis Botulinum Toxin

Start date: July 1, 2017
Phase: Phase 4
Study type: Interventional

The botulinum toxin was first identified in the late 19th century(1). With its 40 different subtype this toxin is produced mainly by the gram positive anaerobic bacteria Clostridium Botulinum(2). This neurotoxin has great affinity to the neuro muscular junction preventing neurotransmitter release in the synaptic space of acetylcholine(3). The first clinical use was reported by Alan Scott in 1980(4). The most commonly used subtype is toxin A commercially found as BOTOX (onabotulinumtoxinA, Allergan, approved by FDA in 1989), Dysport (abobotulinumtoxinA, Medicis, approved by FDA in 2009) and Xeomin (incobotulinumtoxinA, Merz, approved by FDA in 2010). As for other commercial toxins botulinum neurotoxin serotype B product (MYOBLOC™). Neurotoxin Blast generally 12-15 weeks compared to 3-6 month for neurotoxin A. the FDA approved its use for strabismus in 1989(5), blepharospasm and hemifacial spasm in 1990(6,7), cervical dystonia in 2000(8), glabella in 2000, hyperhidrosis in 2004(9), chronic migrane and detrusor overactiviy in 2014. Other off-label uses have emerged like lanyngeal dysponia, chronic pain etc… (10). Multiple studies with a reduced number of patients have aimed to quantify the effect of botulinum toxin on brow higth. Some studies used injections only to the lateral part of the orbicularis,while others added a corrugator injection. We aimed in this study to compare a known techniques in brow lifting and associanting that with 2 frontalis injection techniques. The main objective is to evaluate the shape of the brow and the elevation in multiple brow landmarks before and after the injection and to see if the frontalis botulinum bloc causes brow ptosis

NCT ID: NCT02301923 Not yet recruiting - Clinical trials for Sleep Apnea, Obstructive

Continuous Positive Airway Pressure (CPAP) Compliance in Obstructive Sleep Apnea

CPAPcompl
Start date: November 2014
Phase: N/A
Study type: Observational

This study aims to determine the average compliance of a patient under CPAP therapy for obstructive sleep apnea as well as the various factors that influence it.