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NCT ID: NCT03732456 Recruiting - Pain, Shoulder Clinical Trials

Post-operative Pain After Shoulder Surgery

Start date: July 19, 2018
Phase:
Study type: Observational

A prospective observational study conducted at the American University of Beirut Medical center that targets patients undergoing shoulder surgeries. It is conducted to to prospectively collect patient, surgery and anesthesia-related variables and perform correlation studies with postoperative pain severity, patients' satisfaction and analgesic consumption following shoulder surgery. In addition, identifying predictors for postoperative pain will contribute to adjust pain management protocols as per surgical and patients' factors.

NCT ID: NCT03720769 Recruiting - Depression Clinical Trials

Testing e-Mental Health in Lebanon

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The study objective is to test a guided e-mental health intervention called Step-by-Step for people living in Lebanon. Step-by-Step is a self-help programme delivered through an app or website and aims to treat symptoms of depression and other symptoms of psychological distress. First, a small study will be conducted to test the research procedure. Second, a large study will be conducted to test the effectiveness of Step-by-Step. People residing in Lebanon (i.e. Lebanese, Palestinians and Syrian displaced people), above the age of 18 with symptoms of depression will be recruited through social media, posters, radio and television adverts, etc. Minors (under the age of 18) and people who have plans to end their life will be excluded from the study. To test whether the use of Step-by-Step improves symptoms of depression, two groups will be compared. Participants in the intervention group will receive Step-by-Step, while those in the control group will receive basic information about depression and a list of health centres where they can get face-to-face help that is based on evidence. In addition, participants in the intervention group will receive weekly phone or chat support (up to 15 minutes) provided through lay helpers who were trained and work under the supervision of a trained clinical psychologist. The study hypothesises that participants who receive Step-by-Step will have a higher symptom improvement than participants who receive basic information. In order to assess symptoms of depression and other symptoms of psychological distress, participants in this study will complete several questionnaires three times: At the beginning of the study, after 8 weeks, and then three months later (i.e. 5 months after the beginning of the study).

NCT ID: NCT03708341 Not yet recruiting - Sleep Deprivation Clinical Trials

Exogenous Melatonin in Intensive Care Unit Chronodisruption

EMIC
Start date: November 15, 2018
Phase: Phase 3
Study type: Interventional

To this day, a small number of studies have evaluated the effect of melatonin on the modifications of the characteristics of sleep in critical care units, with mostly a small studied population. However, no study has been realized on a large population, nor has it evaluated the association between genetic factors and response to treatment (melatonin), hence the originality of our study. In our study we hypothesized that systematic melatonin usage in ICU can ameliorate the total sleep time and the fragmentation index and can decrease the confusion related to sleep deprivation.

NCT ID: NCT03703869 Recruiting - Diabetes Clinical Trials

Twelve -Month Study Observing How Insulin-naïve Patients With Type 2 Diabetes Mellitus Manage Diabetes Using Toujeo® After Oral Antidiabetic Drug Failure, the Side Effect of Toujeo®, and The Cost.

ATOS
Start date: March 6, 2018
Phase:
Study type: Observational

Primary Objective: Assess effectiveness of insulin glargine (U300) in achieving glycemic goal measured by hemoglobin A1c (HbA1c). Secondary Objectives: - Assess effectiveness in achieving glycemic goal measured by HbA1c; - Assess effectiveness on change in HbA1c, fasting plasma glucose (FPG) and self-monitored plasma glucose (SMPG) ; - Assess requirement for intensification of therapy by additional antidiabetics. - Assess incidence of hypoglycemia; - Assess other safety endpoints: adverse events (AEs), serious adverse events (SAEs); - Assess change in body weight.

NCT ID: NCT03690622 Completed - Glaucoma Clinical Trials

Effect of Topical Dexmedetomidine on Intraocular Pressure

Start date: December 1, 2017
Phase: Phase 4
Study type: Interventional

Evaluate the short-term safety and efficacy of dexmedetomidine (0.0055%) drops on intraocular pressure (IOP) in healthy eyes.

NCT ID: NCT03684538 Not yet recruiting - Acute Diarrhea Clinical Trials

Efficacy Of Probiotics vs. Zinc vs. Probiotics-Zinc Combination On Acute Diarrhea In Children

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Background: Acute diarrhea in children is still a major health burden worldwide despite all efforts that have been made to reduce its incidence and prevalence. Children are more prone for dehydration that is the most common serious complication of acute diarrhea and can be easily avoided. Initiation of rehydration, early refeeding and giving suitable antimicrobial agents when indicated are the cornerstone for management. In addition, studies have emphasized on the role and efficacy of probiotics and zinc supplements on acute diarrhea in children. Indeed, there are a lot of studies on the role of zinc and probiotic in reducing the severity of acute diarrhea, but not many studies have compared effect of using a combination zinc with probiotics to zinc alone and probiotics alone on acute diarrhea. Objective:To compare the effectiveness of use of probiotics only, zinc only, and combination of zinc with probiotics on the duration and consistency of diarrhea in children presented for acute gastroenteritis. Methods: A total of 240 patients diagnosed with acute diarrhea will be divided into three groups each of 80 patients. The first group will be managed by addition of probiotics to standard treatment. The second group will be managed by addition of zinc to the standard treatment. The third group will be managed by the addition to a combination of zinc and probiotics to standard treatment. The patients will be followed to compare the effect of the given medication on the duration of diarrhea.

NCT ID: NCT03642223 Recruiting - Iron-deficiency Clinical Trials

Central and Peripheral Adiposity and Iron Absorption

Start date: September 10, 2017
Phase: N/A
Study type: Interventional

Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.

NCT ID: NCT03639688 Recruiting - Clinical trials for Fiberoptic Guided Intubation

Endotracheal Tube Threading Over the Fiberoptic Bronchoscope

Start date: September 12, 2017
Phase: N/A
Study type: Interventional

Fiberoptic bronchoscope (FOB) intubation is one of multiple techniques used for endotracheal intubation. It is characterized by the ease of visualization of the different parts of the airway for a correct placement of the endotracheal tube (ETT). This is why it is by far the gold standard technique for intubation in the setting of predicted difficult airway. Even though, the introduction of the scope between the vocal cords can be easily performed, anesthesiologists encounter sometimes difficulty in threading the tube over the bronchoscope. In fact, the tube might kink in the oral cavity or impinge soft tissues like the epiglottis or the arytenoids, which makes it impossible to advance further. Different maneuvers are used to thread the tube including jaw thrust, stretching the tongue, rotating the ETT 90 degrees anticlockwise or using guides and smaller tubes. It was never cited in the literature whether threading the tube on the left or the right side of the tongue would affect the intubation. The hypothesis of this study is that threading the tube on the right labial commissure during FOB intubation has a better success rate than threading the tube on the left labial commissure.

NCT ID: NCT03639558 Recruiting - Aggression Clinical Trials

TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting

TREC
Start date: August 28, 2018
Phase: Phase 4
Study type: Interventional

This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department.

NCT ID: NCT03635684 Recruiting - Pain Clinical Trials

Evaluation of Safety and Efficacy of Subcutaneous Acetaminophen

APAPSubQ
Start date: May 17, 2018
Phase: Phase 2
Study type: Interventional

Subcutaneous perfusion is an underused technique, the effectiveness of which has been demonstrated. A number of drugs of different therapeutic classes, including morphine, have a good level of scientific evidence for use by this route. Subcutaneous Acetaminophen injection is being used in some medical centers, mainly in Europe, despite the lack of definite evidence on its efficacy. This study aims to quantify the degree of effectiveness of subcutaneous Acetaminophen infusions for pain or fever in Palliative Care, as well as determining its safety.