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NCT ID: NCT03806335 Recruiting - Post Operative Pain Clinical Trials

The Effectiveness of Local Infiltration Technique in Adult Tonsillectomy

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

Tonsillectomy is commonly associated with postoperative pain. The modified pre-incision infiltration of anesthetic mixture combined with general anesthesia was shown to decrease post-tonsillectomy pain in children. Hence, the present clinical trial will assess the effectiveness of this technique in adults undergoing tonsillectomy.

NCT ID: NCT03801889 Not yet recruiting - Iron Overload Clinical Trials

SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias

Start date: May 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the safety and tolerability of SP-420 and it's efficacy in terms of lowering iron in subjects with Beta-thalassemia or other rare anemias who need regular blood transfusions.

NCT ID: NCT03800667 Recruiting - Clinical trials for Catheter-Associated Urinary Tract Infection, Ascorbic Acid

Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries

Start date: August 8, 2018
Phase: Early Phase 1
Study type: Interventional

This open-label randomized trial aims at assessing the role of Vitamin C pills in the prevention of catheter-associated urinary tract infections in women undergoing elective gynecological surgeries.

NCT ID: NCT03794427 Recruiting - Cognitive Decline Clinical Trials

Combined Lumbosacral Nerve Block Versus Spinal Anesthesia for Cognitive Function After Hip Prothesis

Start date: January 2, 2019
Phase: N/A
Study type: Interventional

Hip fracture is a potentially devastating event, and serious surgical and medical complications occur frequently especially for elderly patients. Delirium is one of the common complications after hip surgery. Controversy exists regarding the possible impact of type of anesthesia (nerve block versus spinal) upon acute and long-term cognitive decline. The primary objective is to assess the association between type of anesthesia (nerve block vs. spinal anesthesia) and risk of cognitive decline (CD). The secondary objective is to compare intra-operative hemodynamic changes, use of vasopressor drugs, and use of post-operative analgesics with respect to the type of anesthesia. Prospective, double blind randomized clinical trial of hip fracture patients who will be assessed for CD pre- and postoperatively, using the Mini Mental State Examination (MMSE). The presence of CD will be determined at follow-up evaluation up to three months after surgery.

NCT ID: NCT03786172 Recruiting - Smoking Clinical Trials

Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients

Start date: January 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether a brief smoking ENT-resident-based intervention increased smoking cessation in patients with Head and Neck cancer attending a Lebanese university hospital, as compared with usual care.

NCT ID: NCT03782805 Completed - Clinical trials for Vitamin D Deficiency

Effect of Vitamin D Supplementation on Inflammatory Markers

Start date: May 9, 2018
Phase: N/A
Study type: Interventional

Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in some inflammatory markers, especially with patients with type 2 diabetes. The aim of our trial is study the effect of vitamin D supplementation on inflammatory markers in patients having type 2 diabetes.

NCT ID: NCT03775876 Completed - Sedation Clinical Trials

Dexmedetomidine Versus Propofol in Conjunction With Regional Block for Shoulder Arthroscopy

Start date: March 1, 2017
Phase: Phase 4
Study type: Interventional

Operative shoulder arthroscopy under regional block anesthesia often presents with hemodynamic challenges for the anesthesiologist, knowing that a low systolic blood pressure is required to minimize the bleeding. Regional anesthesia is successfully performed to many patients in whom tracheal intubation or the placement of a laryngeal tube is undesired. Propofol has traditionally been used to provide sedation in patients undergoing shoulder arthroscopy under regional anesthesia. In contrast to Propofol, Dexmedetomidine is a highly selective α-2 adrenoceptor agonist that has been shown to provide sedation, analgesia and anxiolytic effects with minimal respiratory depression. Due to the effect of both drugs on blood pressure, the investigators set out to compare intraoperative hemodynamics of both drugs, along with the surgeon's satisfaction and the degree of comfort provided to patients undergoing interscalene brachial plexus block for shoulder arthroscopy. The investigators also assessed whether the type of anesthetic agent used for sedation accounted for other differences in intra and post-operative outcome measures.

NCT ID: NCT03759964 Recruiting - Clinical trials for Anemia, Iron Deficiency

Effects of Ferinject® on Anemia and Transfusion Rates After Cardiac Surgery

FCAACS
Start date: December 15, 2018
Phase: Phase 4
Study type: Interventional

Several studies using new forms of intravenous iron showed that it is effective in treating perioperative anemia in orthopedic and digestive surgery. Effects of ferric carboxymaltose have not been assessed in the settings of cardiac surgery. This study will compare ferric carboxymaltose to placebo in a randomized trial design where ferric carboxymaltose / placebo will be administered in the postoperative period (Day 1) after cardiac surgery. A total sample size of 200 patients (100 per group) will be needed. The FCAACS trial will assess the impact of administering intravenous iron (Ferric carboxymaltose) after cardiac surgery with cardiopulmonary bypass (CPB) on the: - incidence of postoperative anemia - incidence of postoperative transfusion - incidence of complications related to intravenous iron All the surgeries will be performed by the same surgical team and follow-up will be ensured by the same Cardiac Surgery Unit (CSU) team according to department's standard protocols. Participants in the Ferric carboxymaltose group will receive 1g of Ferric carboxymaltose diluted in 100 mL of IV isotonic serum saline, whereas participants in the Placebo group will receive 100 mL of IV Placebo

NCT ID: NCT03758079 Completed - Uremic Pruritus Clinical Trials

Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus

Start date: June 1, 2018
Phase: Phase 4
Study type: Interventional

This is a single blind randomized trial to compare efficacy and side effects of Gabapentin with Doxepin. Hemodialysis patients with uremic pruritus at one dialysis center of Saint George Hospital University Medical Centre were included in this study. Patients were divided into 2 groups to receive either 10 mg Doxepin daily or Gabapentin at a dose of 100mg after each hemodialysis session (increased as tolerated) for 4 weeks, after which patients were treated reversley. Pruritus severity and its effect on quality of life will be assessed by using visual analog scale (VAS), 5-D pruritus scale and dermatology life quality index (DLQI). Include patients will have to fill these forms at baseline and at end of week1, week2 and week4

NCT ID: NCT03748732 Active, not recruiting - Nanophthalmos Clinical Trials

Extensive Circumferential Partial Thickness Sclerectomy in Nanophthalmic Eyes

Start date: January 1, 2011
Phase: N/A
Study type: Interventional

Purpose: To describe an extensive scleral excision technique to treat or prevent uveal effusion in nanophthalmic eyes. Design: Prospective interventional case series. Methods: - Setting: Institutional. - Patient Population: Consecutive patients with nanophthalmos were operated on by one surgeon. - Intervention Procedure: A single, 90% thickness scleral window extending from immediately behind the extraocular muscle insertions to the vortex veins was performed for 3 and 1/4 quadrants as a circumferential strip. - Main Outcome Measure: Resolution or prevention of uveal effusion.