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Uveitis clinical trials

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NCT ID: NCT06310837 Not yet recruiting - Uveitis Clinical Trials

Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis

Start date: March 27, 2024
Phase: N/A
Study type: Interventional

This is a multi-center, prospective, randomized controlled non-inferior clinical study. A total of 120 subjects with non-infectious intermediate, posterior, or panuveitis were enrolled in Zhongshan Ophthalmic Center and three other centers. They were randomly assigned to the experimental group and the control group according to ( 1 : 1 ). We hypothesized that adalimumab biosimilars combined with immunosuppressive agents in the treatment of non-infectious uveitis is not inferior to glucocorticoids combined with immunosuppressive agents, and there are no additional adverse events and safety issues.

NCT ID: NCT06273748 Recruiting - Uveitis Clinical Trials

RChildUV:Study on Non-infectious Chronic Uveitis in Pediatric Age

Start date: February 10, 2022
Phase:
Study type: Observational

Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases

NCT ID: NCT06260449 Active, not recruiting - Uveitis Clinical Trials

Different Treatment Approaches of Presumed Trematode-Induced Uveitis

Start date: October 21, 2023
Phase: N/A
Study type: Interventional

Different Treatment Approaches of Presumed Trematode-Induced Uveitis including periocular injection and medical treatment Nd laser treatment

NCT ID: NCT06258915 Not yet recruiting - Clinical trials for Non Infectious Uveitis

Treatment FOr Corticosteroid Dependent UveitiS

FOCUS
Start date: March 1, 2024
Phase: Phase 3
Study type: Interventional

FOCUS is the first prospective randomized study comparing standard of care (mycophenolate mofetil) to adalimumab in recently active non infectious uveitis (NIU) with steroid dependency. There is no firm evidence or randomized trials that compared classical immunosuppressive compounds to biological agents; or identified the best treatment in this condition. The burden of NIU has been reduced with the use of immunosuppressive agents and biologics, raising the question of which of these compounds should be preferentially used in recently active NIU with steroid dependency.

NCT ID: NCT06250881 Active, not recruiting - Clinical trials for Ocular Complications in AIDS Patients, Such as Fundus Opportunistic Infections, Microangiopathy, and Uveitis

Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation

Start date: October 1, 2023
Phase:
Study type: Observational

Through a cross-sectional descriptive analysis of ophthalmic consultation of AIDS patients in the past 3 years, the basic characteristics of patients were described according to whether there was fundus change, and the clinical characteristics and risk factors of CMVR patients with or without RD were compared.

NCT ID: NCT06161415 Not yet recruiting - Uveitis Clinical Trials

Safety, Tolerability, and Distribution of Topical Laquinimod Eye Drops : a Phase 1 Study

LION
Start date: January 2024
Phase: Phase 1
Study type: Interventional

The LION Study is a prospective, open-label, single-center phase 1 clinical trial to evaluate the safety, tolerability, and distribution of Laquinimod administered as topical eye drops for two weeks in human participants.

NCT ID: NCT06102408 Not yet recruiting - Uveitis Clinical Trials

Relevance and Efficiency of SecOnd Line Workup for Uveitis

RESOLVE
Start date: November 15, 2023
Phase:
Study type: Observational

The first-line etiological workup is currently poorly codified, and some patients undergo sequential investigations. However, the reason which lead the clinician to perform subsequent exams, and the relevance of such exams, remain to be determined. The main objective of the study was to assess the relevance of a second-line workup of patients with uveitis.

NCT ID: NCT06085079 Recruiting - Uveitis, Posterior Clinical Trials

Ixekizumab for the Management of Refractory Non-Infectious Uveitis: A Proof-of-Concept Study

Start date: June 1, 2022
Phase: Phase 4
Study type: Interventional

The objective of this study is to explore the efficacy of ixekizumab in treating patients with a diagnosis of non-infectious intermediate, posterior, panuveitis, or chronic steroid-dependent anterior uveitis who had failed treatment with a classic synthetic DMARD including methotrexate, mycophenolate, cyclosporin, azathioprine, cyclophosphamide and/or at least one anti-TNF agent including adalimumab, infliximab, etanercept, golimumab or certolizumab.

NCT ID: NCT06070935 Recruiting - Uveitis Clinical Trials

Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Start date: January 15, 2024
Phase:
Study type: Observational

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

NCT ID: NCT05984758 Not yet recruiting - Clinical trials for Juvenile Idiopathic Arthritis

Imaging Based Uveitis Screening for Children With Juvenile Idiopathic Arthritis

UVESCREEN1
Start date: May 1, 2024
Phase: N/A
Study type: Interventional

This study seeks to describe, for children undergoing uveitis surveillance following a new diagnosis of juvenile idiopathic arthritis, the feasibility metrics of undertaking a randomised comparative study of routine slit lamp examination (SLE) versus imaging based (anterior segment optical coherence tomography, OCT) surveillance in order to inform the development of a larger multi-centre trial.