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NCT ID: NCT04430569 Recruiting - Pulmonary Embolism Clinical Trials

Pulmonary Embolism International THrOmbolysis Study-3

PEITHO-3
Start date: August 4, 2021
Phase: Phase 3
Study type: Interventional

In this study, we will assess the efficacy and safety of a reduced dose of thrombolytic therapy given in addition to low-molecular-weight heparin in patients with intermediate-high-risk acute pulmonary embolism. Half of participants will receive thrombolytic treatment, while the other half will receive a placebo.

NCT ID: NCT04429542 Recruiting - Colorectal Cancer Clinical Trials

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Start date: June 1, 2020
Phase: Phase 1
Study type: Interventional

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

NCT ID: NCT04428944 Recruiting - Atrial Fibrillation Clinical Trials

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

STARAF3
Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: 1. PV antral isolation alone (PVAI) 2. PV antral isolation plus ablation of drivers (PVAI+drivers) 3. PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation technology using more efficient open irrigated tip cooling and contact force sensing.

NCT ID: NCT04428879 Recruiting - Retinoblastoma Clinical Trials

Topotecan Episcleral Plaque for Treatment of Retinoblastoma

STEP-RB
Start date: June 16, 2020
Phase: Phase 1
Study type: Interventional

This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active residual or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

NCT ID: NCT04428528 Recruiting - Breast Cancer Clinical Trials

Photoacoustic Imaging for Characterizing Breast Masses and Breast Tumor Response to Neoadjuvant Chemotherapy

Start date: February 13, 2017
Phase:
Study type: Observational

Our objective in this pilot study will be to identify PA parameters that can distinguish benign vs. malignant lesions, and also, if PA parameters change with within breast tumors during chemotherapy treatment over time.

NCT ID: NCT04428515 Recruiting - Clinical trials for Head and Neck Cancer

Pilot Study to Evaluate Photoacoustic Imaging in Head and Neck Cancer

Start date: April 23, 2019
Phase:
Study type: Observational

In this study, PA imaging will be used to examine the physiological and physical changes in lymph node involvements of head and neck cancer during radiotherapy with or without chemotherapy. Our objective in this pilot study will be to evaluate if PA parameters change within the lymph node involvements during chemoradiation therapy over time. Our hope is to use this information to correlate the changes in measured PA parameters with radiological response.

NCT ID: NCT04428190 Recruiting - Clinical trials for Kidney Transplant; Complications

Prebiotic Therapy to Improve Outcomes of Renal Transplant

Start date: February 23, 2022
Phase: Early Phase 1
Study type: Interventional

An investigator initiated pilot study: two arm, double blind, placebo controlled, randomized, group of approximately 60 patients undergoing a kidney transplant. Participants will be treated with human milk oligosaccharide (HMO) prebiotic versus placebo over 12 weeks from start of the investigational medication date (approximately 3 months) to test whether HMO can improve renal transplant outcomes. Participants will be followed up for 3 months after after they complete the treatment portion of the study. HMO sachets will be administered to determine the safety and efficacy of HMO relative to placebo in improving renal transplant outcomes in patients by reducing delayed graft function and side effects from post transplant therapy.

NCT ID: NCT04428151 Recruiting - Clinical trials for Squamous Cell Carcinoma of Head and Neck

Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)

Start date: August 6, 2020
Phase: Phase 2
Study type: Interventional

This study is designed to assess the safety and efficacy of lenvatinib in combination with pembrolizumab versus standard of care (SOC) chemotherapy, and to also assess the safety and efficacy of lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and a programmed cell death protein 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitor. The primary hypothesis is that lenvatinib + pembrolizumab is superior to SOC chemotherapy with respect to ORR per modified Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by blinded independent central review.

NCT ID: NCT04427904 Recruiting - Postoperative Pain Clinical Trials

Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery

Start date: June 1, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the efficacy of Bupivicaine and Lidocaine for postoperative pain control in thyroid surgery.

NCT ID: NCT04426786 Recruiting - Parkinson Disease Clinical Trials

Exercise & Brain Energetics in PD

EBEPD
Start date: January 26, 2021
Phase: N/A
Study type: Interventional

There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects. PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.