Clinical Trials Logo

Filter by:
NCT ID: NCT03197935 Not yet recruiting - Clinical trials for Triple-negative Breast Cancer

A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer

Start date: July 31, 2017
Phase: Phase 3
Study type: Interventional

This is a global Phase III, double-blind, randomized, placebo-controlled study designed to evaluate the efficacy and safety of neoadjuvant treatment with atezolizumab (anti-programmed death-ligand 1 [anti-PD-L1] antibody) and nab-paclitaxel followed by doxorubicin and cyclophosphamide (nab-pac-AC), or placebo and nab-pac−AC in participants eligible for surgery with initial clinically assessed triple-negative breast cancer (TNBC).

NCT ID: NCT03197402 Not yet recruiting - Muscle Loss Clinical Trials

Leucine-enriched Nutraceutical and Attenuating Muscle Loss

Start date: November 2017
Phase: N/A
Study type: Interventional

This leucine-enriched protein gummy (as a gummy bar/slab) will be studied to address age-related loss of muscle mass and strength/function in older persons. The product is small volume (approximately 35 g per serve) and low energy (approximately 100 kcal per serve). It is easy to chew and swallow with the consistency of a firm Jello. In addition, it contains an effective dose of leucine in a high-quality protein matrix consisting of milk proteins. Understanding the efficacy of this product on changes in levels of blood amino acids and the molecular signaling required to enhance muscle growth will provide helpful insight for the suggestion of supplemental use.

NCT ID: NCT03196856 Not yet recruiting - Healthy Clinical Trials

Brock Exercise And Supplement Trials

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

This study will analyze the effects of Greek yogurt consumption and an 8 week exercise intervention on muscle size, body composition and bone health in untrained, university-aged males.

NCT ID: NCT03196258 Not yet recruiting - Pain, Postoperative Clinical Trials

Cognitive Behavioural Therapy to Reduce Persistent Post-Surgical Pain After Fracture

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures. In order to study this relationship, researchers at McMaster University have developed the Somatic Pre-Occupation and Coping (SPOC) questionnaire, which identifies illness beliefs that may help to predict which patients are at risk for ongoing pain, reduced quality of life, and delays in returning to work and leisure activities after a fracture requiring surgical treatment. Previous research using the SPOC questionnaire suggests the possibility that fracture patients with illness beliefs that put them at risk for developing ongoing pain could be identified early in the treatment process. These patients may benefit from cognitive behavioural therapy (CBT) which is designed to modify such thoughts with the goal of reducing ongoing pain and improving quality of life. The goal of this study is to determine if CBT is effective in reducing ongoing pain and improving quality of life in fracture patients who show illness beliefs that may place them at risk for developing ongoing pain.

NCT ID: NCT03195738 Completed - Clinical trials for Mild Traumatic Brain Injury

Feasibility of a Cognitive Intervention for Youth Post Concussion

Start date: July 25, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion

NCT ID: NCT03195504 Not yet recruiting - Bariatric Surgery Clinical Trials

High-flow Nasal Oxygenation in Obese Patients During Apnea

Start date: June 2017
Phase: N/A
Study type: Interventional

Before going off to sleep patients are given oxygen to saturate blood with oxygen to extend time before a decrease in the level of oxygen in the blood occurs. During this period, obese patients have a faster decrease in the level of oxygen in their blood. This study uses a device called "high-flow nasal cannula" (HFNC), which delivers humidified high-flow oxygen through 2 small plastic tubes placed just inside nostrils. In the intensive care unit settings this device has been used extensively and has become a standard practice. Purpose of this study is to determine whether these high-flow nasal cannula increase the time safely when going to sleep during elective surgery.

NCT ID: NCT03195114 Recruiting - Paravalvular Leak Clinical Trials

Cardiac MRI for Post-TAVR Paravalvular Leak Assessment

Start date: January 1, 2017
Phase: N/A
Study type: Observational

The objectives of this study are to: a) evaluate and correlate the severity of paravalvular leak (PVL) assessed by both cardiac MRI and transthoracic echocardiography (TTE) after transcatheter aortic valve replacement (TAVR) with Medtronic Evolut-R or Evolut PRO bioprostheses; b) assess the inter and intraobserver variability of both imaging methods; and c) correlate the severity of PVL with post-TAVR changes in LV remodeling and clinical outcomes.

NCT ID: NCT03194802 Recruiting - Insomnia Chronic Clinical Trials

Efficacy of Sleeping Without Pills (SWOP), an Online Drug Tapering Program

Start date: June 5, 2017
Phase: N/A
Study type: Interventional

The aims of the study are to determine whether an online drug tapering program can lead to successful drug tapering in hypnotic dependent insomnia and whether such tapering is associated with improved daytime functioning and sleep.

NCT ID: NCT03194503 Not yet recruiting - Clinical trials for Intubation Complication

Tracheal Intubation Coaching in NICUs

Start date: October 2017
Phase: N/A
Study type: Interventional

The purpose of the study is to determine the efficacy of video coaching training for neonatology attending providers on tracheal intubation procedural outcomes in neonatal ICUs.

NCT ID: NCT03193580 Not yet recruiting - Healthy Clinical Trials

Accelerating Motor Learning in Pediatrics

Start date: June 20, 2017
Phase: N/A
Study type: Interventional

Non-invasive brain stimulation can both study and potentially treat neurological disorders. Transcranial direct-current stimulation (tDCS) is an emerging safe and tolerability form of stimulation and has been used increasingly over the last decade. The purpose of this research is to see if two different types of tDCS can improve motor function in healthy children. tDCS has been shown to safely enhance hand motor function in healthy adults, and those that have suffered stroke and other conditions. Recently the investigators demonstrated that tDCS may enhance hand motor function in healthy children, however, how it does so is unknown. In addition to assessing changes in motor function when tDCS is given during motor skill training, the investigators will perform various tests before and after stimulation to understand the changes that happen in the brain accompanying motor skill learning and brain stimulation. The investigators hypothesize that there will be an accelerated acquisition of motor skill, when training is paired with conventional anodal tDCS, HD-tDCS, or sham tDCS.