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Colonoscopy clinical trials

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NCT ID: NCT06319924 Completed - Colorectal Cancer Clinical Trials

Fixed Low-dose Simethicone Combined With Macrogol 4000 (PEG) Reduces Colon Bubble Formation in Colonoscopy

XIMEPEG-RL
Start date: February 1, 2020
Phase:
Study type: Observational

Several randomised studies have shown that the addition of low-dose Simethicone to the bowel preparation was sufficient to reduce the presence of bubbles during colonoscopy. The aim of this study was to evaluate the efficacy and safety of a bowel preparation containing low-dose Simethicone on bubble formation. Patients and Methods This prospective, real-life, phase 4 study was conducted from February 2020 to May 2021, in five private endoscopy centres, among adult patients undergoing a colonoscopy. Clinical, endoscopic and histological parameters were collected on e-CRF. The primary endpoint was the measurement of bubble formation in the various colon segments.

NCT ID: NCT06317350 Recruiting - Colonoscopy Clinical Trials

Clinical Study to Evaluate the Efficacy and Safety of GNS-212-E in Bowel Preparation for Colonoscopy

GNS-212-E
Start date: March 11, 2024
Phase: Phase 3
Study type: Interventional

This is a prospective, randomized, single-blind, parallel, active-controlled, and multi-center Phase III clinical trial.

NCT ID: NCT06282367 Completed - Colonoscopy Clinical Trials

Bowel Preparation for Colonoscopy With Oral Lactulose

Start date: July 1, 2021
Phase:
Study type: Observational [Patient Registry]

Background and Aims: The quality of colonoscopy is critically influenced by bowel preparation. Polyethylene glycol (PEG) is considered the gold standard regimen for bowel preparation, however due to the necessity of large volume of patient's tolerance is impaired, especially in the elderly population. Lactulose has been adopted in a few centers as a novel alternative for colonoscopy preparation. This study aimed to investigate the efficacy-safety profile of a lactulose-based bowel preparation in comparison to PEG for colonoscopy. Methods: Prospective non-blinded comparative study, developed in two tertiary centers from July 2021 to April 2023. Outpatients undergoing colonoscopy were randomly divided into 2 groups: Group 1 (111 patients): PEG and Group 2 (111 patients): Lactulose. The following clinical outcomes were assessed for each group: degree of bowel clearance using the Boston Score, colorectal polyp detection rate, adenoma detection rate, tolerability and side effects.

NCT ID: NCT06279481 Recruiting - Pain Clinical Trials

Effect of Virtual Reality (VR) on Pain Relieve During Colonoscopy

Start date: March 2024
Phase: N/A
Study type: Interventional

Purpose: To evaluate the effectiveness and safety of virtual reality (VR) technology in alleviating pain during colonoscopy. Design and Methods: In the context of a single-centered, prospective, randomized controlled study, the pain levels experienced during colonoscopy are compared between the VR group and the control group.

NCT ID: NCT06223347 Recruiting - Clinical trials for Inflammatory Bowel Diseases

Improved and Simplified Staining Technique for Dysplasia Detection in Colitis

IST-DDC
Start date: January 2024
Phase:
Study type: Observational

Comparing chromoendoscopy to a digital staining technique and White light in patients with IBD attending scheduled surveillance colonoscopy

NCT ID: NCT06208956 Not yet recruiting - Colonoscopy Clinical Trials

A Low Dose Dexmedetomidine in Sedation Colonoscopy

Start date: January 20, 2024
Phase: N/A
Study type: Interventional

104 patients who undergo painless colonoscopy from January 20,2024 to February 29,2024 will be randomized to two groups: propofol group and dexmedetomidine group. In the dexmedetomidine group,dexmedetomidine is infusion intravenously with a loading dose of 0.5 μg kg-1 for 10 min, then infusion at 0.3 μg kg-1 h-1 according to the ideal body weight of the patient until the end of colonoscopy. In the propofol group, Propofol is administrated 1 mg kg-1 intravenously, then titrated given by 0.5 mg kg-1 during the whole process.

NCT ID: NCT06192394 Not yet recruiting - Colonoscopy Clinical Trials

Gum Chewing and Abdominal Vibration: Impact on Bowel Preparation Quality and Patient Satisfaction

Start date: March 2024
Phase: N/A
Study type: Interventional

Colorectal cancers are a significant global health issue, underscoring the critical importance of screening programs for early detection and effective treatment. The success of a colonoscopy is largely contingent on the quality of bowel preparation. Inadequate bowel preparation can diminish the effectiveness of a colonoscopy and lead to the oversight of lesions. Previous research has demonstrated the positive effects of diet, education, and polyethylene glycol use on bowel preparation. However, there is limited research on the impact of methods such as gum chewing and abdominal vibration. This study aims to assess the effects of gum chewing and abdominal vibration, in addition to diet and medication, on the quality of bowel preparation and patient satisfaction in the pre-colonoscopy bowel preparation process. The study employs a randomized controlled single-blind experimental design with three distinct groups: a control group, a gum chewing group, and an abdominal vibration group. Each group will be evaluated based on bowel preparation quality and patient satisfaction. Bowel preparation quality will be determined using the Boston Bowel Preparation Scale, and factors such as polyp detection, the processability of the colonoscopy, and cecal intubation time will also be assessed. Patient satisfaction levels will be evaluated by considering how satisfied patients are with the colonoscopy process, taking into account complaints before and after the procedure. The outcomes of this study will contribute to a better understanding of the impact of gum chewing and abdominal vibration on the quality of bowel preparation and patient satisfaction before colonoscopy. Identifying effective methods to enhance bowel preparation quality can elevate the standard of nursing care, contributing to a healthier society. Simultaneously, this research can improve the comfort and efficacy of the colonoscopy process for patients and enhance the effectiveness of colorectal cancer screening programs, thereby benefiting public health.

NCT ID: NCT06173297 Completed - Colorectal Cancer Clinical Trials

Assessing the Agreement Between Endoscopic and Histopathological Diagnosis of Colorectal Sessile Serrated Lesions.

Start date: February 1, 2020
Phase:
Study type: Observational

The goal of this observational study was to assess the degree of agreement between the endoscopic and anatomopathological diagnosis of sessile serrated colorectal lesions in adult patients undergoing colonoscopy in Hospital Sírio-Libanes. The main questions it aimed to answer were: - The degree of agreement between endoscopic and anatomopathological diagnosis of sessile serrated colorectal lesions by calculating the Kappa Value of agreement. - To establish the detection rate of sessile serrated lesions and adenomas in the Endoscopy Department at Hospital Sírio-Libanês. - To evaluate the degree of agreement between endoscopic and anatomopathological diagnosis of sessile serrated colorectal lesions based on the resection method. - To assess the accuracy, positive predictive value, and negative predictive value of endoscopic diagnosis of serrated lesions compared to anatomopathological diagnosis. The data were prospectively collected through a form specifically designed for this project, that was completed immediately after the examination by the performing colonoscopist. All patients enrolled in this study agreed to participate in it and signed an informed consent form prior to the colonoscopy.

NCT ID: NCT06173258 Recruiting - Colonoscopy Clinical Trials

Water Exchange Colonoscopy With Artificial Intelligence-assisted Detection

Start date: December 18, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare the detected adenoma per colonoscopy (APC) in participants undergoing screening, surveillance, and positive fecal immunochemical test (FIT) or guaiac fecal occult blood test (gFOBT). There will be two arms in this study: WE water control and water plus artificial intelligence (AI). The main question it aims to answer is whether the addition of AI into water exchange (WE) colonoscopy increases APC than WE alone. The control method will use water instead of air inserted into the colon. The study method will use a commercially available AI system plus water during the procedure. Researchers will compare APCs to see if the addition of AI increases detection of adenomas during WE colonoscopy.

NCT ID: NCT06159855 Active, not recruiting - Colonoscopy Clinical Trials

The Effect of Bowel Preparation Training Given to Patients Undergoing Colonoscopy

training
Start date: January 15, 2023
Phase: N/A
Study type: Interventional

This study was planned to examine the effect of bowel preparation training and monitoring given to patients planned to undergo colonoscopy on the level of anxiety, compliance with bowel preparation and bowel cleansing. The research sample was collected at the Sultan II. University of Health Sciences affiliated to the Istanbul Provincial Health Directorate between December 2022 and August 2023. 34 intervention and 34 control groups will be randomly selected from outpatients who apply to the Colonoscopy Unit of Abdülhamid Han Training and Research Hospital and meet the inclusion criteria. In this study, it is aimed to increase the effect of bowel preparation training, supported by nurses in the clinic and via instant messaging/calling or communication application, on patients' anxiety level, level of compliance with bowel preparation, and bowel cleansing in patients scheduled for colonoscopy.