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Pain clinical trials

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NCT ID: NCT04869553 Not yet recruiting - Pain Clinical Trials

Analgesic Efficacy of Hypnosis and Virtual Reality in Repetitive Pain Care

PADIS
Start date: June 1, 2021
Phase: N/A
Study type: Interventional

The originality of this study is the comparison of different distractibility techniques (hypnosis and virtual reality) in the very heterogenous contexts of pain management. This study will consider all types of care situations. The study's cross-over design will take into account this heterogenous context. The results will be representative of real-life situations where care for pain involves a wide range of contexts.

NCT ID: NCT04869293 Not yet recruiting - Pain Clinical Trials

Lithotripsy and Analgesia With 3D Hypnosis Mask

LAHMA
Start date: April 2021
Phase: N/A
Study type: Interventional

The study is a randomised trial of hypnosis with 3D virtual reality headset (intervention group) versus control group with no hypnosis and no virtual reality headset to compare remifentanil consumption during shock wave lithotripsy.

NCT ID: NCT04869085 Recruiting - Pain Clinical Trials

The Use of a Digital Application for Reporting Pain and Pain Management in Home Hospice

ePainSupport
Start date: March 8, 2020
Phase: N/A
Study type: Interventional

Poor adherence to pain management and high pain intensity associated with serious, advanced illness is a major public health concern. This randomized clinical trial will test the efficacy of a newly enhanced digital pain and pain management application (e-PainSupport) for use in a home hospice setting. The e-PainSupport application delivers an education module about pain management to patients and caregivers, expedites pain reporting to nurses, and facilitates adherence to pain management. The overall goal of the e-PainSupport application is to improve pain management and reduce patient pain intensity in the home hospice setting.

NCT ID: NCT04866745 Not yet recruiting - Pain Clinical Trials

Magnetotherapy Versus Microwave Combined With Exercise for Knee Osteoarthritis.

MT-MW-EX
Start date: April 29, 2021
Phase: N/A
Study type: Interventional

The high prevalence of knee osteoarthritis and the absence of well-defined protocols for the application of Magnetotherapy (MT), makes it necessary to investigate the effect of this therapy on patients with knee osteoarthritis. Furthermore, no studies are comparing the effectiveness of the two interventions proposed in this project (MT) and microwaves (MW), which are routinely applied in clinical practice, without solid scientific evidence to justify their use. The purpose of the present clinical trial is to compare MT with MW both combined with a therapeutic exercise program in patients with painful knee osteoarthritis and its influence on pain and function.

NCT ID: NCT04864223 Completed - Pain Clinical Trials

Classifying and Predicting Long-term Pain and Function in Older Adults

Start date: August 1, 2018
Phase:
Study type: Observational

This project will use novel methods to detect clinically meaningful subgroups of older adults based on long-term trajectories of bothersome pain and function. It will then identify older adults at high risk of experiencing poor long-term pain and function. Anticipated results will provide new insights into long-term patterns of pain and function across the aging process and identify potential predictors of each trajectory.

NCT ID: NCT04864080 Not yet recruiting - Depression Clinical Trials

Transdiagnostic Cognitive Biomarkers

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

NCT ID: NCT04862884 Not yet recruiting - Pain Clinical Trials

A Trial to Evaluate the Safety and PK Profile of HRS4800 in Healthy Subjects

Start date: May 3, 2021
Phase: Phase 1
Study type: Interventional

The study will be conducted to evaluate the safety and PK profile of HRS4800 tablets after single oral administration in different dose levels compared to placebo.

NCT ID: NCT04862871 Not yet recruiting - Pain Clinical Trials

Enhancing Analgesia in Chronic Pain Through Exercise

Start date: June 2021
Phase: N/A
Study type: Interventional

Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies. To date, experiencing a painful stimulus has been known to disrupt motor activity in an attempt to minimize injury. However, physical activity, even when it increases ongoing pain initially, has been shown to significantly reduce pain symptoms eventually through neuromodulation. In both acute and chronic pain cohorts, exercise protocols and neuromodulation paradigms have produced exercise-related analgesia. Problem: It is not currently understood which brain regions are implicated in exercise-based analgesia and what brain regions moderate this response. Approach: The investigators intend to provide a physical activity intervention designed to promote exercise-induced analgesia. This intervention will be performed in a group of pediatric subjects with Chronic Widespread Pain Disorder. An exercise (n=10), no exercise (n=10) and healthy control (n=10) group will be recruited. Aims: This study has three aims: (1) To understand how thermal pain sensitivity, pain symptoms and motor performance are impacted in patients with chronic pain after an exercise-based intervention. (2) To evaluate the brain regions involved in a simple motor task as well as how motor activity influences activity in pain regions of the brain. (3) To evaluate the network structure of the brain, with special emphasis on motor and pain regions, in youth with a pain disorder who have undergone an exercise-based intervention. Exercise-based therapy in pediatric subjects with a chronic pain condition is predicted to reduce pain symptom reporting through biasing activity in pain regions during motor performance. Significance: Findings from this investigation will address the clinical side of pain management strategies and provide potential therapeutic targets and feasibility data. The investigators anticipate that findings will show how pain and motor regions of the brain interact at the network level and if this interaction can be modulated through exercise. Findings will also evaluate the brain regions that mediate the analgesic properties of an exercise-based pain therapy and provide future therapeutic targets.

NCT ID: NCT04862832 Not yet recruiting - Pain Clinical Trials

Reduction of Thermal Pain From a Personalized Musical Intervention : Effect of Musical Preference

Start date: April 2021
Phase: N/A
Study type: Interventional

This is a randomized, 3-days study with the objective to compare the modulation of pain from our musical intervention to the CPT-induced analgesia and silence. The mean pain felt before and after CPT, the silence, and at three times points for the music conditions, 2.20 minutes, 11.30 minutes and 20 minutes, will be evaluated. Based on previous data, the sample size has been estimated, and 30 participants will be enrolled. They will undergo four conditions: CPT, silence, Most-Liked Music (MLM) and Least-Liked Music. The music used will be Music Care, a personalized musical intervention used in clinical settings. It has a U shape in six sections that each have different tempi, number of instruments and volume. There will be two music conditions: the most-liked-music (MLM) and least-liked-music (LLM) conditions. The sequence rated the highest will be listened to during the MLM and the one rated the lowest will be listened during the LLM condition. MLM will be considered as a score between 7 and 10 on the preference scale. LLM will be considered as a score between 0 and 4. The cold pressor test will consist in the immersion of the participants' arm in 10 degrees circulating water for two minutes. The silence condition will consist of six minutes in which the participants stay seated on the examination chair without access to their phones or other provided distractions. There will be three testing days for each participants. They will be seated in a comfortable chair in a quiet room. The first day, before the pain tests started, consent form will be read and signed by the participants. After, the MLM and LLM will be determined. Then, the sociodemographic questionnaire, the two State Trait Anxiety Inventory (STAI) subscales, Beck Depression Inventory (BDI) and Pain Catastrophizing Scale (PCS) will be administered. Finally, a first two minutes pain test will be performed (T1), the CPT and a second pain test (T2). The second and third day will consist of first the STAI, the state subscale, the silence condition and then one music condition. The order of music condition will be randomized. The silence condition will consist of a first pain test (T3 or T8), six minutes of silence and then a second pain test (T4 or T9). Those 6 minutes will be chosen in order to equal the duration between the end of the first pain test and the start of the second one of the music intervention condition. In fact, for the music condition, whether it's the MLM or LLM, the first pain tests will be performed at 2.20 minutes after the music started (T5 or T10). The second will be after the relaxation phase at 11.30 minutes (T6 or T11) and the third after the whole 20-minutes cycle (T6 or T12). A post music condition score of the MLM and LLM on the same preference scale as the selection will be administered. Quantitative data will be described using mean, standard deviation, median, extreme values (minimum and maximum) and the number of missing data. Qualitative data will be described by their distributions in terms of numbers and percentages by class as well as the number of missing data. The normality condition will be verified using the Shapiro-Wilk test. Quantitative variables will be compared by the paired Student test if conditions were checked or by the non-parametric test of the signed Wilcoxon ranks, as part of the comparison of 2 modalities. The quantitative variables will be compared between the 3 conditions using a repeated-measure ANOVA or Friedman test. Tests will be bilateral, with a threshold of 5%.

NCT ID: NCT04861753 Completed - Pain Clinical Trials

The Effects of Reiki and Back Massage on the Pain and Vital Signs

Start date: July 9, 2017
Phase:
Study type: Observational [Patient Registry]

The practice of Reiki and back massage applications in support of pharmacological treatment is among the nursing initiatives and these practices increase the autonomy of the profession. The aim of this study was to determine the effects of Reiki and back massage on pain, analgesic use and vital signs in women who had undergone open abdominal hysterectomy. This was an experimental study with a single, blinded, pretest-posttest control group. The population of the study consisted of women who had abdominal hysterectomy in the Obstetrics Clinics at Gazi Yasargil Training and Research Hospital and Dicle University Hospital between July 2017 and February 2018. The patients were divided into three groups: Reiki, back massage and control, with 34 patients in each group. Reiki or back massage were applied for 20 minutes once a day to the patients in the Reiki and back massage groups.