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Pain clinical trials

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NCT ID: NCT05489939 Completed - Pain Clinical Trials

Safety and Efficacy of Compound Methyl Salicylate Liniment for Topical Pain: a Multicenter Real-World Study in China

Start date: May 2014
Study type: Observational

The purpose of this phase Ⅳ clinical trial was to evaluate the safety and efficacy of compound methyl salicylate liniment (Ammeltz) in a real-life environment in China. This multicenter clinical trial was conducted at 22 hospitals/centers in China between May 2014 and March 2015. The primary aim of the trial was to evaluate the safety of Ammeltz in a real-life environment. The secondary monitoring objective was to evaluate the efficacy of Ammeltz in the treatment of soft tissue injury pain in a real-life environment. In principle, according to the guide for drug monitoring in production enterprises in China, the number of patients included in the statistical analysis of key drug monitoring should not be less than 3000 in order to provide ample information about the trial drug. Therefore, the sample size of this study was chosen to be 3600 cases, considering the dropout rate of the subjects.

NCT ID: NCT05488158 Completed - Pain Clinical Trials

Assessing the Impact of OMT on Physician Pain

Start date: October 22, 2020
Phase: N/A
Study type: Interventional

Osteopathic Manipulative Therapy/Treatments (OMT) are a non-pharmacologic option for treating patients' pain. As the opioid crisis has developed, the requests for OMT have grown in consequence. This has been associated with a recent focus of opioid addiction and overdose death concerns among physicians and patients. However, the physical toll that OMT takes on the physicians providing the treatments has yet to be robustly investigated. Due to the longitudinal nature of chronic pain, OMT delivery becomes a substantial commitment for the physician offering OMT as an option, especially if the intent is to reduce opioid utilization. Many of the patients treated in our clinic have obesity as a co-morbidity to their chronic pain. The size differential between the patient and provider commonly results in multiple techniques being required to treat the patient's somatic dysfunction, which equates to increased exertion by the provider for each new pain patient. Anecdotal reports from the providers have described a decreased motivation to offer OMT to pain patients due to their own soreness from treating the patients they already have on their panel. Furthermore, the physicians are rarely able to take the time away from their practice during business hours to get their own physical health needs addressed in a timely manner. This study looked at the participants' pain levels from offering OMT to their patients and their motivation to offer OMT as a non-pharmacological intervention for treating pain. The participants will have protected time built into their schedule where a board certified doctor of osteopathy will treat them every two weeks. Over the study's course, the participants' pain levels and motivation to offer OMT to their patients was assessed. Objective outcome measures came from the participant's patient panel reports. Changes in the number of OMT office visits they provide, the number of systems they treated and the morphine equivalents they prescribed was tracked. The project's hypothesis followed that purposefully attending to the participant's physical health will improve their motivation to offer OMT, reduce their pain and reduce their opioid prescribing.

NCT ID: NCT05488080 Not yet recruiting - Pain Clinical Trials

PAINED: Project Addressing INequities in the Emergency Department

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes. Our overarching goal is to eradicate health care inequities through evidence-based interventions. The objectives of this proposal are to develop and test the impact of two interventions on overcoming clinician implicit bias and mitigating inequities in the management of pain among children seeking care in the emergency department for the treatment of appendicitis or long bone fractures.

NCT ID: NCT05487183 Not yet recruiting - Pain Clinical Trials

Test Retest Reliability of OA and OH

Start date: August 2022
Phase: N/A
Study type: Interventional

The goal of this study is to measure the test retest reliability of offset analgesia (OA) and onset hyperalgesia (OH) across multiple study visits. OA and OH are quantitative sensory tests (QST) thought to measure how the brain modulates pain. This study will use a heat thermode to induce OA and OH in healthy, pain-free volunteers across 3 study visits. Additional QST measures and survey data relevant to pain modulation will be collected. This study lays the foundation required to use OA and OH as tools to measure pain modulation in clinical trials. Following their validation, we anticipate that OA and OH will serve as predictive and therapeutic biomarkers, which will aid both in the development of novel analgesics and in treatment selection leading to the personalization of pain management.

NCT ID: NCT05486533 Not yet recruiting - Pain Clinical Trials

The Effect of Acupressure After Angiography on Pain Level and Hemodynamic Variables

Start date: September 30, 2022
Phase: N/A
Study type: Interventional

This randomized controlled study evaluates the effect of acupressure application on the pain level patients after angioography. The hypothesis of this study is that acupressure reduces pain levels and stabilizes hemodynamic variables.

NCT ID: NCT05484414 Recruiting - Pain Clinical Trials

Safety and Pharmacokinetics of SAD/MAD Oral Doses of SRP-3D (DA)

Start date: January 13, 2023
Phase: Phase 1
Study type: Interventional

This is a two-part randomized, double-blind, placebo-controlled study.

NCT ID: NCT05482919 Recruiting - Pain Clinical Trials

The Adolescent Surgery Experience: A Mixed Methods Analysis

Start date: June 14, 2022
Study type: Observational

New chronic pain and opioid use are reported as prevalent among adolescents undergoing major surgery; many unanswered questions remain regarding recovery and the anticipated pain trajectory across procedures and the interaction between pain treatment, acute inflammation and new chronic pain. Broadly, the proposed study will characterize the adolescent's postoperative recovery experience, and establish the anticipated pain trajectory across a range of procedures.

NCT ID: NCT05481255 Recruiting - Pain Clinical Trials

Association With Spinal Needle-puncture Pain and Menstrual Phase

Start date: August 2, 2022
Study type: Observational

This prospective observational study aimed to evaluate the relationship between menstrual phase cycles and spinal needle-puncture pain during spinal anesthesia in female patients of reproductive age.

NCT ID: NCT05481086 Not yet recruiting - Fibromyalgia Clinical Trials

Pain Severity in Fibromyalgia Syndrome

Start date: August 15, 2022
Study type: Observational [Patient Registry]

Fibromyalgia Syndrome (FMS) is a complex syndrome that mainly includes the musculoskeletal system and is characterized by many symptoms such as chronic widespread pain, fatigue and sleep disorders, cognitive dysfunctions, regional pain syndrome, psychiatric disorders. The existence and importance of the multidimensional nature of chronic pain in FMS has been demonstrated. Factors such as pain intensity, persistence of pain, pain-related disability, and novelty of onset are all important characteristics of a chronic pain condition. Therefore, there was a need for a global measure of chronic pain severity that summarized different measures of pain and a graded classification of chronic pain was proposed. Patients with chronic pain such as FMS are known to have a greater negative impact than many chronic medical conditions. Chronic pain severity in FMS has been found to be associated with various conditions such as function and health status, and it has been shown that reduction in pain severity provides broadly beneficial results on these conditions. However; there are no studies in which chronic pain severity in FMS is classified by grading and investigating the relationship of different pain severity degrees with disease severity and other symptoms. The aim of this study is to evaluate whether the severity of the disease, kinesiophobia, and concerns about pain differ in individuals with different pain severity by grading the severity of pain in individuals with fibromyalgia syndrome.

NCT ID: NCT05480228 Not yet recruiting - Clinical trials for Painful Diabetic Neuropathy

EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Start date: August 10, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 12 weeks.