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Breast Cancer clinical trials

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NCT ID: NCT06383663 Not yet recruiting - Breast Cancer Clinical Trials

Supraclavicular Lymph Node Dissection for Ipsilateral Supraclavicular Lymph Node Metastatic Breast Cancer

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The purpose of this study was to compare the efficacy of surgical dissection of supraclavicular lymph nodes combined with radiotherapy versus radiotherapy alone in patients with ipsilateral supraclavicular lymph node metastasis.

NCT ID: NCT06382818 Not yet recruiting - Breast Cancer Clinical Trials

Personalization of Breast Radiotherapy According to Loco-regional Recurrence Risk and Toxicity Probability

PROBA
Start date: April 26, 2024
Phase: N/A
Study type: Interventional

Our objective is based on a personalized approach of adjuvant breast radiotherapy by selecting patients according to tumor recurrence and toxicity risk.

NCT ID: NCT06375187 Not yet recruiting - Breast Cancer Clinical Trials

Engineering Tumor Infiltrating Lymphocytes Injection (GC203 TIL) for the Treatment of Advanced Malignant Solid Tumors

KUNLUN-001
Start date: May 1, 2024
Phase: Phase 1
Study type: Interventional

A clinical trial to assess the safety and efficacy of engineered Tumor Infiltrating Lymphocytes (TIL) for the treatment of Advanced Malignant Solid Tumors

NCT ID: NCT06371768 Not yet recruiting - Breast Cancer Clinical Trials

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

AYA STEPS
Start date: April 1, 2025
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended follow-up care.

NCT ID: NCT06364267 Not yet recruiting - Breast Cancer Clinical Trials

Babytam vs Babyexe in Post-menopausal Women at High Risk for Breast Cancer.

BabyTears
Start date: September 1, 2024
Phase: Phase 2
Study type: Interventional

The purpose of the study is to determine if 6 and 12 months of treatment with Tamoxifen at lower dose is superior to Exemestane at lower dose on quality of life.

NCT ID: NCT06362993 Not yet recruiting - Clinical trials for Breast Cancer Female

Breast Cancer Screening in Ghana

Start date: April 2024
Phase: N/A
Study type: Interventional

This study is designed to test the feasibility of two intervention on promoting early screening for breast cancer in rural Ghana. In one intervention, screening for breast cancer, diabetes and hypertension will be offered together. In another intervention, a series of sessions with men will be conducted with a goal to change gender attitudes and increase support to women. The investigators' long-term goal is to test these interventions in a large-scale randomized controlled trial. The specific aims of this feasibility study are to: 1) refine the study materials, including the curriculum for the sessions with men, by consulting with an expert advisory committee and a local committee, and 2) determine the feasibility of the two interventions in four clinic zones in Yilo-Krobo district in eastern Ghana (1 clinic in control, 1 clinic in the first intervention, and 2 in the second intervention). This trial registration is for the second specific aim.

NCT ID: NCT06362096 Not yet recruiting - Breast Cancer Clinical Trials

A Multicenter, Prospective Study of Diarrhea Tolerance of Pyrotinib Combined With Trastumab and Taxane in the First-line Treatment of HER2-positive Advanced Breast Cancer

Start date: May 2024
Phase: Phase 2
Study type: Interventional

To explore a reasonable and effective way to reduce the incidence of grade 3 or above diarrhea caused by pyrotinib

NCT ID: NCT06361940 Not yet recruiting - Breast Cancer Clinical Trials

Molecular Analyses to Identify Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer

Start date: August 2024
Phase: Phase 2
Study type: Interventional

This is an exploratory phase II interventional study that initiates standard-of-care anti-estrogen treatment preoperatively for 4-12 weeks (+/- 2 weeks).

NCT ID: NCT06351332 Not yet recruiting - Breast Cancer Clinical Trials

A Phase I/II Single-arm Trial of Azenosertib (ZN-c3) Combined With Carboplatin and Pembrolizumab in Patients With Metastatic Triple-negative Breast Cancer (ZAP-IT)

Start date: September 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This research is being done to evaluate the safety and effectiveness of a drug currently known as Azenosertib (ZN-C3) in combination with the drugs carboplatin and pembrolizumab in metastatic triple-negative breast cancer. The names of the study drugs involved in this study are: - Azenosertib (a type of WEE1 inhibitor) - Carboplatin (a type of platinum compound) - Pembrolizumab (a type of monoclonal antibody)

NCT ID: NCT06348654 Not yet recruiting - Breast Cancer Clinical Trials

New Digital Person-based Care Model in Patients With HER2-negative Advanced Breast Cancer

InPERSON
Start date: March 30, 2024
Phase:
Study type: Observational

The goal of the InPerson study is to employ all resources in a digital listening platform to benefit the quality of life of patients (QoL) with advanced HER2-negative breast cancer. The care pathway of patients with this type of disease represents an optimal setting for the implementation of an innovative narrative medicine pathway that, aided by integrative therapies, aims to support and accompain them in their treatment journey with a continuum of care. Moreover, the narrative medicine platform will implement the actual "static" way to define QoL with the classic Patient-Reported Outcomes (PROs) questionnaires, that reflect the patient status at a certain time point and not as a dinamic entity. It is on the basis of these assumptions that the present application project on the use of the DNMLAB digital narrative diary in the oncology department of the Fondazione Policlinico Gemelli was born.