Type 2 Diabetes Clinical Trial
Official title:
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM) - Role of Intramyocellular Lipid Content and Mitochondrial Dysfunction in Myocardial Insulin Resistance and Their Correction With Pioglitazone
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
PRIMARY OBJECTIVES
1. To quantitate myocardial insulin sensitivity using positron emission tomography (PET)
with 18F-deoxyglucose in type 2 diabetes mellitus (T2DM) and control subjects.
2. To quantitate pericardial fat using magnetic resonance spectroscopy in T2DM and control
subjects.
3. To quantitate cardiac function using magnetic resonance imaging and echocardiography in
T2DM and control subjects.
4. To examine the effect of pioglitazone on myocardial insulin sensitivity, pericardial fat
content, and cardiac function.
SECONDARY OBJECTIVES To examine the relationships between myocardial insulin sensitivity,
pericardial fat content, and cardiac function.
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