Stroke Clinical Trial
Official title:
Study on the Relationship Between the Change of Cholesterol Efflux Capacity and the Prognosis of Coronary Artery Disease in Real Clinical Practice
Verified date | January 2018 |
Source | Lu'an Municipal Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to investigate the change of cholesterol efflux capacity in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the prognosis.
Status | Not yet recruiting |
Enrollment | 200 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 30 Years to 70 Years |
Eligibility |
Inclusion Criteria: Signed informed consent; First diagnosis of CAD through CAG; aged 30-70. Exclusion Criteria: Patients with severe liver or kidney damage; Taking statins within the last 3 months; Patients who had been diagnosed with CAD and treated with oral medication; Chronic diseases of the blood system; Familial hyperlipidemia patients; Patients combining autoimmune disease; Patients combining acute infectious disease; Patients who undertaken surgery or injury; Patients who combining cancer; Patients who taking glucocorticoid replacement therapy. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Lu'an Municipal Hospital | First Affiliated Hospital of Jinan University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the change of cholesterol efflux capacity | the change of cholesterol efflux capacity | before and 6-, 12-, 18-, 24- month after follow-up | |
Secondary | the change of HDL-C subclasses (preß1-HDL?HDL2?HDL3) | the change of HDL-C subclasses (preß1-HDL?HDL2?HDL3) | before and 6-, 12-, 18-, 24- month after follow-up | |
Secondary | the concentration and activity of plasma LCAT | the concentration and activity of plasma LCAT | before and 6-, 12-, 18-, 24- month after follow-up | |
Secondary | coronary revascularization | coronary revascularization | 24 months | |
Secondary | heart failure | heart failure | 24 months | |
Secondary | cardiovascular mortality | cardiovascular mortality | 24 months | |
Secondary | non-fatal myocardial infarction | non-fatal myocardial infarction | 24 months | |
Secondary | non-fatal stroke | non-fatal stroke | 24 months |
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