The Immune System and Psychiatric Disorders

Schizophrenia Clinical Trial

Official title:

The Immune System and Psychiatric Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00184418
• Other study ID #: 94463
• Status: Completed
• Phase: N/A
• First received: September 15, 2005
• Last updated: March 9, 2017
• Start date: January 2005
• Est. completion date: January 2008

Study information

• Verified date: March 2017
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Description:

Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1400
• Est. completion date: January 2008
• Est. primary completion date: January 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria:

• Patients that do not agree to participate in the study

Related Conditions & MeSH terms

• Bipolar Disorder
• Depression
• Depressive Disorder
• Disease
• Mental Disorders
• Personality Disorders
• Problem Behavior
• Psychotic Disorders
• Schizophrenia
• Stress Disorders, Traumatic

Locations

Country	Name	City	State
Norway	St Olavs Hospital, Department of Psychiatry, Østmarka Hospital	Trondheim	Middle Norway

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

References & Publications (2)

Sæther SG, Schou M, Stoecker W, Teegen B, Borowski K, Vaaler A, Kondziella D, Reitan SK. Onconeural Antibodies in Acute Psychiatric Inpatient Care. J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):74-76. doi: 10.1176/appi.neuropsych.16050110. — View Citation

Schou M, Sæther SG, Borowski K, Teegen B, Kondziella D, Stoecker W, Vaaler A, Reitan SK. Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care. Psychol Med. 2016 Dec;46(16):3303-3313. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cytokines		1 year