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Pulmonary Arterial Hypertension (PAH) clinical trials

View clinical trials related to Pulmonary Arterial Hypertension (PAH).

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NCT ID: NCT03523910 Completed - Clinical trials for Pulmonary Arterial Hypertension (PAH)

Right Ventricular Pulmonary Vascular Interaction in Pulmonary Hypertension

Start date: April 25, 2012
Phase: N/A
Study type: Interventional

The goals of this study were two-fold. First, the attempt to quantify the relationships between pulmonary arterial stiffness, right ventricular function and the efficiency of ventricular-vascular interactions in patients with pulmonary arterial hypertension (PAH). Second, the attempt to quantify the effects of exercise on pulmonary arterial stiffness, pulmonary vascular resistance, right ventricular function and the efficiency of ventricular-vascular interactions in patients with PAH.

NCT ID: NCT03362047 Recruiting - Clinical trials for Pulmonary Arterial Hypertension (PAH)

(RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)

Start date: March 1, 2018
Phase: Phase 2
Study type: Interventional

Pilot study to determine the therapeutic effect of two prarallel groups treated with either Riciguat or Macitentan, evaluated by the change in systolic and diastolic RV function within 12 weeks after first drug intake in order to plan a larger Phase II study.

NCT ID: NCT03235401 Recruiting - Clinical trials for Pulmonary Arterial Hypertension (PAH)

The PAH Disability and Bothersomeness Questionnaire

Start date: June 16, 2017
Phase: N/A
Study type: Observational

To develop a patient-reported questionnaire to investigate the impact of PAH (pulmonary arterial hypertension) on patients' daily lives in terms of bothersomeness and disability.

NCT ID: NCT03145298 Recruiting - Clinical trials for Pulmonary Arterial Hypertension (PAH)

ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy

Start date: October 1, 2017
Phase: Phase 1
Study type: Interventional

Pulmonary Arterial Hypertension or PAH is a progressive condition for which there is no cure. Even with substantial pharmacologic advances in the modern treatment era, survival still remains unacceptably poor, as reported in large PAH registries. Preclinical studies suggest that the administration of allogeneic CDCs have the potential to reduce adverse arteriolar remodeling in PAH which was the basis for the approved investigational new drug (IND). The use of CDCs as an adjunctive therapy in patients comprising 4 sub-groups of patients with PAH in which inflammation and immune dysfunction are key pathophysiologic drivers of PAH.

NCT ID: NCT01347216 Recruiting - Clinical trials for Pulmonary Arterial Hypertension (PAH)


Start date: June 2007
Study type: Observational

In view of the manifold options for mono- and combination therapy that have now emerged for patients with pulmonary (arterial) hypertension (PH/PAH), controlled clinical trials can only provide part of the information needed for optimal management. In order to gather adequate data on PAH/PH treatment in routine clinical care, the ongoing COMPERA registry prospectively documents consecutive patients with newly initiated treatment of PAH/PAH since May 2007. The internet-based registry fulfills high quality standards through several measures (planned minimum centre contribution of at least 10 patients per year, automated plausibility checks of data at entry, queries, monitoring with source data verification in >50% of participating centers). It can be applied, among further purposes, for quality assurance: individual centers can confidentially compare their results with the combined outcome of other centers and the recommendations from guidelines. It is expected that the register contributes to optimization of specific drug therapy for PAH and PH. Since July 2013, also children of any age can be documented (COMPERA-KIDS).

NCT ID: NCT00586794 Terminated - Clinical trials for Pulmonary Arterial Hypertension (PAH)

Therapy of Pulmonary Arterial Hypertension (PAH) - Treatment With Sildenafil in Eisenmenger Patients

Start date: December 2007
Phase: Phase 3
Study type: Interventional

Eisenmenger's syndrome presents as a severe clinical picture of polymorbidity that constitutes a great burden at the individual as well as the familial and social level. The combination of critically increased pulmonary vascular resistance, progressive pressure load of the right ventricle and disturbance of pulmonary gas exchange result in long-term polymorbidity. The objective of this study is to provide evidence of improvement of patients exercise tolerance as well as general conditions by treatment with oral sildenafil as a specific pulmonary vasodilator.