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NCT ID: NCT00673751 Enrolling by invitation - Clinical trials for Short Bowel Syndrome

Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome

Start date: n/a
Phase: N/A
Study type: Interventional

The aim of the study is to investigate the effect of the enteric hormone Glucagon-like Peptide (GLP-2) on patients with short bowel syndrome

NCT ID: NCT00703235 Enrolling by invitation - Clinical trials for Diabetic Retinopathy

Intravitreal Bevacizumab for Diabetic Macular Edema

Start date: n/a
Phase: Phase 2/Phase 3
Study type: Interventional

Diabetic macular edema is a common cause of visual loss among diabetic patients. Studies have demonstrated the role of vascular endothelial growth factor (VEGF) in the pathogenesis of edema. This study designed to evaluate the effect of Intravitreal injection of a recombinant monoclonal anti-VEGF antibody, Bevacizumab, for treatment of diabetic macular edema.

NCT ID: NCT00860678 Enrolling by invitation - Clinical trials for Valvular Aortic Stenosis

Physical Activity in Patients After Aortic Valve Replacement (Valve-ex)

Start date: n/a
Phase: N/A
Study type: Interventional

A structured and supervised, 3-month physical activity intervention in patients after aortic valve replacement due to severe stenosis, accompanied by examination of cardiac size and function, exercise capacity and endothelial function before, three and six months after operation; comparison with a non-intervention control group.

NCT ID: NCT01133145 Enrolling by invitation - Limb Salvage Clinical Trials

Allogeneic Vascularized Knee Transplantation

kneeTx
Start date: n/a
Phase: N/A
Study type: Interventional

High energy trauma often results in severe soft tissue, bone and joint injury. Today, many methods and techniques exist to treat theses severely injured extremities. Surgical techniques include open reduction and internal fixation (ORIF), e.g. with screws and plates, soft tissue reconstruction by local or free flaps and joint reconstruction by arthroplasty, e.g. total knee arthroplasty. In few, very severe cases, those methods are not sufficient to restore function and amputation is the only option left. In 1908 the German surgeon Erich Lexer had the idea to transplant a joint. Due to the medical situation at his time the attempts failed. But the idea survived and was processed over the time. Transplant surgery and medicine developed, immunosuppressive drugs were established and animal models proved that bone and joint transplantation is technically feasible. In 1998 the first successful hand and in 2005 the first partial face transplantation was carried out. In 1996 we started our clinical femur and knee joint transplantation project.

NCT ID: NCT01307527 Enrolling by invitation - Clinical trials for Ehlers-Danlos Syndrome Type 6

Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI

Start date: n/a
Phase: N/A
Study type: Interventional

Brittle Cornea Syndrome and Ehlers-Danlos Syndrome (EDS) type VI are rare collagen-connective tissue disorders that predispose affected individuals to the development of perforated corneas from the mildest of eye trauma or even spontaneously. Clinical studies evaluating riboflavin-corneal crosslinking have found that it dramatically increases corneal rigidity. Given the success and safety of riboflavin crosslinking, the investigators believe that it can increase the corneal stability in patients affected these disseases, preventing perforation. It is furthermore possible, that riboflavin crosslinking will allow corneal transplants to successfully be performed on blind eyes that have already perforated and opacified. The purpose of the study is to determine whether corneal crosslinking can be safely performed on individuals with Brittle Cornea Syndrome or Ehlers-Danlos Syndrome type VI.

NCT ID: NCT01317719 Enrolling by invitation - Clinical trials for Biceps Tendon Rupture

Prospective Biceps Study

Start date: n/a
Phase: N/A
Study type: Observational

The primary goal of this study is to determine if surgical repair of the distal biceps fully restores the supination strength of the forearm. Secondarily, the investigators want to examine the insertion site location of the tendon and determine if it correlates with the patients' functional outcome as determined by Disabilities of the Arm, Shoulder, and Hand (DASH), Visual Analog Pain Scale (VAPS), and isometric supination torque testing.

NCT ID: NCT02014350 Enrolling by invitation - Clinical trials for Reverse Total Shoulder Arthroplasty

Outcomes Following Delta Xtend Reverse Shoulder System

Start date: n/a
Phase: N/A
Study type: Observational

To collect medium to long-term survivorship implant outcomes on the DePuy Delta Xtend Reverse Shoulder Stystem.

NCT ID: NCT02412397 Enrolling by invitation - Osteoarthritis Clinical Trials

DePuy Global Unite Shoulder System

Start date: n/a
Phase: N/A
Study type: Observational

To collect medium to long-term survivorship implant outcomes on the DePuy Global Unite Shoulder System

NCT ID: NCT02667158 Enrolling by invitation - Clinical trials for Opioid-Related Disorders

A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or Diversion

Start date: n/a
Phase: N/A
Study type: Observational

To evaluate the reasons patients go to more than one prescriber or more than one pharmacy to obtain prescriptions opioids and assess whether the percentage of patients reporting misuse, abuse and/or diversion increases across defined categories of doctor/pharmacy shopping as defined in Study 4A.

NCT ID: NCT02871232 Enrolling by invitation - Clinical trials for Opioid-related Disorders

Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers

Start date: n/a
Phase: N/A
Study type: Observational

To conduct surveillance for abuse, misuse, overdose, addiction, and death and to evaluate if the REMS meets its surveillance goals, and if it does not, to modify it appropriately based on the metrics. Briefly, therefore, the overall surveillance objective is to evaluate for trends before and after the shared REMS is implemented to collectively assess for changes in abuse, misuse, overdose, addiction, and death for different risk groups and settings.