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Mouth Diseases clinical trials

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NCT ID: NCT03909074 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Clinical Trial of Enterovirus 71(EV71) Inactivated Vaccine in Children Aged 36-71 Months

Start date: March 10, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the non-inferiority of experimental EV71 vaccine compared to the control EV71 vaccine in children aged 36-71 months, to evaluate the non-inferiority of EV71 vaccine used in children aged 36-71 months compared to 6-35 months. The experimental vaccine was manufactured by Sinovac Biotech Co., Ltd, and the control vaccine was manufactured by Institute of Medical Biology Chinese Academy of Medical Sciences.

NCT ID: NCT03903926 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Efficacy Trial of a Commercial EV71 Vaccine

Start date: March 26, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this post-marketing study is to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine post marketing, and explore the protective levels of various enterovirus neutralizing antibodies

NCT ID: NCT03893747 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

Immunity and Safety of Inactivated Enterovirus 71 Vaccine Post-marketing Among Children Aged 6-35 Months in China

Start date: April 2019
Phase: Phase 4
Study type: Interventional

This study evaluates three batches consistency, immunity duration and safety of inactivated Enterovirus 71(EV-A71) vaccine(vero cell) post-marketing among children aged 6-35months in China.3000 subjects will be recruited in this study, of who 1500 subjects will be randomly assigned in a ratio of 1:1:1 to receive one of the three batches of EV-A71 vaccines manufactured by 40L capacity reactor, other 1500 subjects will be randomly assigned in a ratio of 1:1:1 to receive one of the three batches of EV-A71 vaccines manufactured by 150L capacity reactor. Vaccine wil be administrated according to a two doses of schedule given at day 0 and 28. Sample will be collected at day 0, day 56 and at month 13 after vaccinaiton.

NCT ID: NCT03880214 Not yet recruiting - Clinical trials for Stem Cell Transplant Complications

Prevalence of Chronic Oral Graft Versus Host Disease Risk Factors in Pediatric Patients

Start date: April 2019
Phase:
Study type: Observational

our aim is estimating the Prevalence and predicting risk factors for developing chronic oral graft versus host disease in pediatric patients subjected to hematopoietic stem cells transplantation

NCT ID: NCT03873740 Completed - Clinical trials for Hand, Foot and Mouth Disease

Immunogenicity and Safety of Two Different Commercial EV71 Vaccines

Start date: November 6, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the immunogenicity and safety of sequential vaccination of two EV71 inactived vaccines in healthy infants aged 6-35 months.

NCT ID: NCT03855397 Completed - Oral Cavity Disease Clinical Trials

Pain and Safety of Microneedles in Oral Cavity

Start date: January 16, 2018
Phase: N/A
Study type: Interventional

A randomized, crossover, double-blind, placebo-controlled, one-session clinical trial with 30 male volunteers was performed to access pain and safety of microneedle topical application in different regions of the oral cavity.

NCT ID: NCT03804749 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Study to Evaluate the Tolerance and Pharmacokinetics of Suramin Sodium

Start date: December 19, 2018
Phase: Phase 1
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, single-dose with three incremental doses, Phase 1 study to evaluate the tolerance and pharmacokinetics of suramin sodium for injection in Chinese healthy adults.

NCT ID: NCT03736070 Recruiting - Oral Disease Clinical Trials

Assessment of Routine Oral Screening Programs for New Prisoners

DepiDent
Start date: March 1, 2018
Phase:
Study type: Observational

In 2018, 10 detention centers in France will start organisational programs to improve the quality of screening of oral diseases, relatively to French recommendations, among new prisoners in France. Our study aims 1) to assess the prevalence and nosology of oral diseases ; 2) to describe the care pathway of participants during their stay in the detention center where they were included ; 3) to assess the cost of care per patient, from a societal perspective, using a top-down method.

NCT ID: NCT03723174 Not yet recruiting - Oral Disease Clinical Trials

Impact of an Educational Program on Gingival Status and Oral Health Related Quality of Life

Start date: June 1, 2019
Phase:
Study type: Observational [Patient Registry]

This research targets the evaluation of the impact of oral health educational programs on the gingival status and oral health related quality of life in early adolescence of the Egyptian population. Each participant will benefit from the education of the proper oral hygiene practices under the supervision and follow up of the investigator in addition to the potential improvement of his/ her oral health related quality of life.

NCT ID: NCT03679988 Not yet recruiting - Oral Disease Clinical Trials

Prevalence of Oral Mucosal Alterations in Mucocutaneous Ocular Disorders

Start date: October 2018
Phase:
Study type: Observational

The patients will be selected from the pool of the Clinics (Rheumatology, Ophthalmology and Dermatology) of Faculty of Medicine and (Diagnostic center and Oral Medicine) of Faculty of Dentistry -Cairo University. For each eligible participant, a full history will be obtained followed by thorough clinical examination.