Clinical Trials Logo

Mouth Diseases clinical trials

View clinical trials related to Mouth Diseases.

Filter by:

NCT ID: NCT03241030 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial

Start date: August 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to see if sucralfate, a medication commonly used for patients with stomach ulcers, may help pediatric patients with mouth ulcers decrease their pain level and improve their ability to drink.

NCT ID: NCT03240744 Active, not recruiting - Clinical trials for Hand, Foot and Mouth Disease (HFMD)

The Phase IVc of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell)

Start date: June 22, 2017
Phase: Phase 4
Study type: Interventional

Enterovirus 71 (EV71), a major pathogen causing hand-foot-and-mouth disease (HFMD) worldwide, is a member of the Human Enterovirus species A, family Picornaviridae. Its infection occasionally leads to severe diseases and death, with central nervous system (CNS) damage. Recently, except of inactivated vaccine, several EV71 vaccine candidates have been evaluated in animals but no final results of clinical trials, such as attenuated vaccine, subunit vaccine. A formalin-inactivated EV71 vaccine (Human Diploid cell, KMB-17 Cell) has been finished phase I, II and III clinical trials and licensed by SFDA in China at Dec. 3, 2015. Based on the results of clinical trials, the protective efficacy of inactivated EV71 vaccine is 97% against HFMD caused by EV71. The phase IV clinical trial has been carried out from July 2016. The purpose of phase IVc is to evaluated the immunogenicity of the inactive EV71 vaccine in large scale population of Chinese children (from 6 to 71 months old) in Hubei Province, China.

NCT ID: NCT03123705 Recruiting - Oral Disease Clinical Trials

El Paso Public Health Biorepository

EPB
Start date: May 26, 2017
Phase: N/A
Study type: Observational

The prevalence of tooth decay and other oral disease are often overlooked indicators of overall public health. To improve the understanding of oral health in El Paso, the City of El Paso Health Department has teamed up with Texas Tech University Health Sciences Center El Paso in a collaborative effort to determine the factors that contribute to poor oral hygiene, and lead to cavities and periodontitis. The team will collect saliva, oral debris, leftover teeth and plaque from children and young adults to study oral infections, markers of inflammation, and other contributors to tooth decay and oral illnesses. Samples also will be stored for future investigations. This joint effort will provide a better picture of oral health in El Paso, and will define a framework for prevention, earlier diagnosis, and better treatment.

NCT ID: NCT03082365 Not yet recruiting - Clinical trials for Chronic Kidney Diseases

Oral Findings in Chronic Kidney Disease

Start date: n/a
Phase: N/A
Study type: Observational

The patients with chronic kidney disease suffer from many oral problems affecting the quality of life. The aim of our study is to assess their oral health to provide the proper management and increase their awareness

NCT ID: NCT03074188 Not yet recruiting - Clinical trials for Chronic Kidney Diseases

Prevalence of Oral Findings in Chronic Kidney Disease

Start date: n/a
Phase: N/A
Study type: Observational [Patient Registry]

There are severe deficiency of database concerning the oral health status in both pre-dialysis and end stage renal disease in Egyptian population. Our aim in the present study is to assess the oral health of the chronic kidney disease patients to increase their awareness and minimize all the possible risk factors, to achieve a proper management for all oral problems.

NCT ID: NCT03001986 Active, not recruiting - Clinical trials for Hand, Foot and Mouth Disease (HFMD)

The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children

Start date: September 2016
Phase: Phase 4
Study type: Interventional

Enterovirus 71 (EV71), a major pathogen causing hand-foot-and-mouth disease (HFMD) worldwide, is a member of the Human Enterovirus species A, family Picornaviridae. Its infection occasionally leads to severe diseases and death, with central nervous system (CNS) damage. Recently, except of inactivated vaccine, several EV71 vaccine candidates have been evaluated in animals but no final results of clinical trials, such as attenuated vaccine, subunit vaccine. A formalin-inactivated EV71 vaccine (Human Diploid cell, KMB-17 Cell) has been finished phase I, II and III clinical trials and licensed by SFDA in China at Dec. 3, 2015. Based on the results of clinical trials, the protective efficacy of inactivated EV71 vaccine is 97% against HFMD caused by EV71. The phase IV clinical trial has been carried out from July 2016. The purpose of phase IVb is to evaluated the safety and efficacy of the inactive EV71 vaccine in large scale population of Chinese children (from 6 to 71 months old) in Hubei Province, China.

NCT ID: NCT02931032 Enrolling by invitation - Periodontitis Clinical Trials

Diagnosis of Common Oral Diseases by Signature Volatile Profiles

Start date: November 2016
Phase: N/A
Study type: Interventional

Oral diseases tend to be exacerbated due to delayed diagnosis. Patients avoid visiting their dentist even for regular checkups, and develop late stage disease, jeopardizing the treatment outcome. There is an urgent need for an inexpensive and minimally invasive technology that would serve as a diagnostic aid, allowing 1) efficient early detection and 2) treatment customization. Diagnostic modalities based on the detection of volatile organic compounds in the exhaled air may answer this need. The proposed research aims at investigating signature molecular patterns of common oral diseases, as a first step toward the development of a computerized non-invasive diagnostic breath test, based on the "Na-Nose" device. The proposed research will be divided to three distinct stages. Stages 1-2 will serve for the detection and analysis of Volatile Organic Compounds connected with common oral diseases, and for the characterization of a specified diagnostic nano-receptor array. Stage 3 will serve for the clinical testing of the array and as a proof of concept. In a pilot experiment, headspaces above colonies of S.mutans, S.sanguis, P.gingivalis and F.nucleatum were trapped and analyzed using Gas Chromatography Mass Spectrometry (GC-MS). A unique VOC signature, consisting of 20-35 molecules, was detected for each of the bacterial strains. These promising results allow the development of an algorithm for statistical detection of oral diseases by their VOC profile alone. Bacteria and distressed tissues emit unique VOCs, and additional research is required with other types and strains of bacteria - including cultivation of samples from active periodontal and carious lesions. The results of the proposed research may be revolutionary. A simple and non-invasive air sampling at home or in a drugstore will significantly increase patient compliance and curability rates, and decrease healthcare expenditure.

NCT ID: NCT02913235 Completed - Mouth Diseases Clinical Trials

Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene

Start date: September 2016
Phase: N/A
Study type: Interventional

The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to discontinuation of oral hygiene.

NCT ID: NCT02894372 Completed - Mouth Diseases Clinical Trials

Faringomoss Effectiveness in Inhibiting Acute Throat Pain and Discomfort

Start date: January 2015
Phase: N/A
Study type: Interventional

The purpose of the study was to assess the effectiveness of Faringomoss in reducing the throat discomfort and pain in patients with acute throat diseases and postoperative patients after throat surgeries.

NCT ID: NCT02889497 Not yet recruiting - Clinical trials for Hand Foot and Mouth Disease

Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months

Start date: September 2016
Phase: Phase 4
Study type: Interventional

This study evaluates the safety,three batches consistency and immunity duration of the post-marketing inactivated Enterovirus Type 71 (EV71) vaccine in children aged 6-71 months.This study has two groups:safety observation group and immunogenicity observation group.20000 subjects will receive 2 doses vaccines and be observed for safety among 2 epidemic cycles of HFMD.In the immunogenicity observation group, 900 subjects will be randomly received 3 batches vaccines(2 doses),and blood sampled at days 0 and 56.