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NCT ID: NCT00006068 Not yet recruiting - Diabetes Mellitus Clinical Trials

Does Islet Transplantation Eliminate Hypoglycemia?

Start date: n/a
Phase: N/A
Study type: Interventional

Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the pancreas of a person who did not have diabetes into a person with diabetes should eliminate high blood sugar levels. We wish to determine if it will also eliminate low blood sugar. To do so we will give insulin to lower the blood sugar, measure the levels of the hormones that normally raise blood sugar levels (e.g., glucagon and epinephrine) and then stop the insulin and see if blood sugar levels return to normal. Because we anticipate that the transplanted islets will produce insulin, but not glucagon, this study may also tell us if regulated insulin production alone can prevent hypoglycemia in humans.

NCT ID: NCT00023283 Not yet recruiting - Clinical trials for Opioid-Related Disorders

Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1

Start date: n/a
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the Standard Medical Management (SMM) vs. SMM enhanced with additional education about addiction and recovery (Enhanced Medical Management, EMM)

NCT ID: NCT00062530 Not yet recruiting - HIV Infections Clinical Trials

Safety of an Oral HIV Vaccine in HIV Uninfected Volunteers

Start date: n/a
Phase: Phase 1
Study type: Interventional

This study will test the safety of and immune response to an oral HIV vaccine in healthy volunteers. The vaccine in this study uses a weakened bacterium called Salmonella typhi to deliver an HIV gene into the body through the mouth. The body then produces an HIV protein from the gene; this protein stimulates an anti-HIV immune response. The vaccine contains only one of the many substances that HIV needs to make more copies of itself, so the vaccine itself cannot cause HIV or AIDS.

NCT ID: NCT00067977 Not yet recruiting - Clinical trials for Kidney, Polycystic, Autosomal Dominant

Clinical Trial to Slow the Progression of ADPKD

Start date: n/a
Phase: N/A
Study type: Interventional

This study will determine whether certain blood pressure medications will slow cyst growth or keep kidneys functioning longer in patients with autosomal dominant polycystic kidney disease (ADPKD). The study will take place at several sites in the United States. The start date of the study has not yet been determined.

NCT ID: NCT00138372 Not yet recruiting - Clinical trials for Plasmodium Falciparum Malaria

Human Immunity to MSP-1 in Western Kenya

Start date: n/a
Phase: N/A
Study type: Observational

This is a study of 125 healthy male and female Kenyan adults aged 18 years and above, and 300 healthy male and female Kenyan infants enrolled at 1 month of age and followed to 3 years of age. Twenty healthy adults (US residents) who have no self-reported history of Malaria exposure, infection or travel to malaria endemic areas of the world will serve as Malaria Naive Negative Controls. The proposed study represents a continuation of molecular and immunologic studies done in human populations describing mechanisms of protection against malaria infection and disease. Human investigation of those experiencing natural exposure to malaria infections are justified since they will eventually be the target population for testing malaria vaccine safety and efficacy.

NCT ID: NCT00149669 Not yet recruiting - Cocaine Dependence Clinical Trials

Employment-Based Reinforcement to Motivate Naltrexone Ingestion and Drug Abstinence in the Treatment of Drug Addiction. - 1

Start date: n/a
Phase: N/A
Study type: Interventional

A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users. Participants will be offered an opioid detoxification and naltrexone induction. Participants who complete the naltrexone induction will be randomly assigned to one of three groups. All groups will be invited to work in the Therapeutic Workplace and prescribed naltrexone for 26 weeks. The groups will differ in the contingencies imposed to work and earn salary. Work Plus Naltrexone Contingency participants will be required to ingest naltrexone to work, and will receive a brief pay decrease for missing a dose. Work Plus Naltrexone and Abstinence Contingency participants will be required to ingest naltrexone to work, and will receive a brief pay decrease for missing a dose of naltrexone or for providing an opiate or cocaine positive urine sample. Work Plus Naltrexone Prescription participants will be prescribed naltrexone, but will not be required to ingest it to work. This study will provide a rigorous evaluation of a novel employment-based intervention, the Therapeutic Workplace, to promote naltrexone ingestion and drug abstinence in a population of injection drug users who are at considerable risk of spreading or contracting HIV infection. Hypotheses being tested in this study are: Naltrexone ingestion will be maintained in the two groups exposed to the employment-based naltrexone treatment significantly more than the group exposed to usual-care treatment package. Opiate abstinence will be maintained in the two groups exposed to the employment-based naltrexone treatment significantly more than the group exposed to usual-care treatment package. Cocaine abstinence will be increased in the group reinforced for cocaine abstinence significantly more than the group not exposed to abstinence reinforcement.

NCT ID: NCT00153400 Not yet recruiting - Clinical trials for Cardiovascular Diseases

California WISEWOMAN Project

Start date: n/a
Phase: N/A
Study type: Interventional

The purpose of this trial is to provide low-income, under- or un-insured 40- to 64-year-old women with the knowledge, skills, and opportunities to improve diet, physical activity, and other lifestyle behaviors to prevent, delay and control cardiovascular and other chronic diseases.

NCT ID: NCT00163813 Not yet recruiting - Critical Illness Clinical Trials

The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study

ENTERIC
Start date: n/a
Phase: N/A
Study type: Interventional

This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal [NJ] tube) and standard feeding in critical illness.

NCT ID: NCT00164086 Not yet recruiting - Myeloma Clinical Trials

Atorvastatin in Myeloma

Start date: n/a
Phase: Phase 1
Study type: Interventional

The purpose of this trial is to study the effects of a medication already widely used to treat cardiovascular disease and diabetes, in reducing the progression of myeloma.

NCT ID: NCT00172341 Not yet recruiting - Asthma Clinical Trials

Sublingual Immunotherapy With House Dust Mite Extract in Asthmatic Children

Start date: n/a
Phase: Phase 4
Study type: Interventional

Asthma, the airway inflammatory disorder, is an important chronic disease in children. About 10~15% children are bothered with this. Allergens, such as house-dust mites (HDM), animal dander (i.e. cats and dogs), and seasonal pollens, are often implicated as causative and triggering factors of respiratory attacks in children with asthma. Among them, mites are the most common indoor allergen associated with asthma worldwide. It appears that SLIT is somewhat effective and safe. However, on the current evidence, further studies are needed to define the indications, the duration of treatment and therapeutic optimal dose of standardized allergen extracts in relation to efficacy and side effects before it is recommended for routine clinical use. The objective of the present study was to investigate the effects and safety of StaloralTM, the standardized extracts of D. pt. and D. f., in asthmatic children allergic to HDM.