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NCT ID: NCT00596115 Temporarily not available - Clinical trials for Amyotrophic Lateral Sclerosis

Treating Amyotrophic Lateral Sclerosis (ALS) With R(+) Pramipexole Dihydrochloride Monohydrate at 60 mg/Day

Start date: n/a
Phase: N/A
Study type: Expanded Access

R(+) pramipexole dihydrochloride monohydrate [R(+)PPX], an experimental neuroprotective drug, is provided in this open label extension study to ALS patients who have participated in earlier clinical protocols.

NCT ID: NCT00826956 Temporarily not available - Clinical trials for One Lung Ventilation

The Change of Pulmonary Blood Flow During One Lung Ventilation

Start date: n/a
Phase: N/A
Study type: Expanded Access

To investigate the changes of regional pulmonary blood flow in nondependent lung by transesophageal echocardiography during one lung ventilation

NCT ID: NCT00839345 Temporarily not available - Clinical trials for Coronary Artery Disease

Clopidogrel Resistance and the Possibility of Its Affection

Start date: n/a
Phase: N/A
Study type: Expanded Access

The purpose of the study is to determine, whether the resistance to clopidogrel could be affected by higher doses of this drug, or by replacement of clopidogrel with another ADP-antagonist ticlopidine.

NCT ID: NCT00870636 Temporarily not available - Clinical trials for Retinopathy of Prematurity

Use of Pan-Vascular Endothelial Growth Factor Receptor (Pan-VEGF) Blockade for the Treatment of Retinopathy of Prematurity (ROP) (Compassionate Use BLOCK-ROP)

Start date: n/a
Phase: N/A
Study type: Expanded Access

The purpose of this study is to provide access to intravitreal injection of Avastin in high-risk infants who do not otherwise qualify for study NCT00702819, an investigational multi-site study examining Avastin use for retinopathy of prematurity.

NCT ID: NCT01262950 Temporarily not available - Parkinson's Disease Clinical Trials

Development of a Fall Prevention and Fall Detection System for Ambulatory Rehabilitation of Parkinson's Patients

Start date: n/a
Phase: N/A
Study type: Expanded Access

The investigators plan to conduct a first-stage experiment by recruiting ten subjects, including five PD patients and five non-PD patients. In the beginning, the information collected by the portable motion detector is used to compare the difference in the activities performed by PD and non-PD patients. Besides, the algorithm will be developed to identify the gait patterns of PD patients. Once the system detects the abnormal gaits, such as shuffling and festinating steps or freezing of gait, auditory cues will be given to the PD patients and caregivers by their sides. It can help the patient to maintain normal gait and improve the effectiveness of rehabilitation, as well as preventing falls in daily activities. Moreover, in case of accident falls, the real-time fall detection mechanism alerts the nearest caregiver for instant support and delivers this information to the remote family members and medical personnel. After that, a second-stage experiment will be carried out by recruiting another five PD patients. By comparing the gait patterns identified by the system against those identified manually by the staff, the performance of the proposed system on fall prevention will be examined. For the patients and their family members, the developed system enhances the patients' safety in their daily activities. As for the medical personnel, it serves as an affordable tool that benefits the rehabilitation of PD patients in an easy manner.

NCT ID: NCT01297101 Temporarily not available - Clinical trials for Non-small Cell Lung Cancer

Evaluating Efficacy and Safety of Erlotinib Versus Gemcitabine Plus Cisplatin as Neoadjuvant Chemotherapy

Start date: n/a
Phase: N/A
Study type: Expanded Access

The aim of this study is to investigate the efficacy and safety of Tarceva versus combination of Gemcitabine plus Cisplatin as neoadjuvant treatment in patients with stage IIIA-N1,N2 NSCLC with EGFR activating mutation in exon 19 or 21.

NCT ID: NCT01406535 Temporarily not available - Clinical trials for Coronary Artery Disease

Improvement of Myocardial Blood Flow by PhosphoDiesterase 5 Inhibition in Coronary Artery Disease

SYDNEY
Start date: n/a
Phase: N/A
Study type: Expanded Access

The aim of this study is to prospectively investigate if intermittent Phosphodiesterase 5 inhibition for 15 weeks improves myocardial perfusion by angiogenesis in patients with therapy refractory myocardial ischemia due to coronary artery disease judged to be unsuitable for surgical or percutaneous revascularisation. For proof of efficacy the following tests will be performed at baseline and one day and 4 weeks after discontinuation of therapy: Exercise tolerance will be evaluated by bicycle exercise testing. Blood tests will be performed to evaluate markers of angiogenesis (endothelial progenitor cells, vascular endothelial growth factor, basic fibroblast growth factor). The improvement of myocardial perfusion will be tested functionally as increase of coronary flow reserve by positron emission tomography. Moreover, changes in ventricular function, symptoms and quality of life will be assessed.

NCT ID: NCT01889745 Temporarily not available - Healthy Clinical Trials

A Phase I Clinical Study of the Safety, Tolerability and Pharmacokinetics of HX-1171 in Healthy Male Subjects.

HX-1171
Start date: n/a
Phase: N/A
Study type: Expanded Access

This study is designed to multiple dose and dose escalation study

NCT ID: NCT02011880 Temporarily not available - Breast Cancer Clinical Trials

Standardization Research of TCM Syndrome Differentiation and Treatment on Advanced Breast Cancer

Start date: n/a
Phase: N/A
Study type: Expanded Access

The purpose of this clinical research study is to learn if the clinical effects of combined Chinese herbal medicine with endocrine therapy is better than endocrine therapy alone in improving the quality of life and shrinking and slowing the growth of the cancer in women with breast cancer bone metastasis.

NCT ID: NCT02094222 Temporarily not available - Byler Disease Clinical Trials

Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease

Start date: n/a
Phase: N/A
Study type: Expanded Access

Byler Disease is the result of a homozygous missense (G308V) mutation in the ATP8B1 gene. The disease is typically manifest in the first year of life on the basis of complications of cholestasis; common presentations include jaundice, poor growth, bleeding related to vitamin K deficiency, and/or weak bones related to vitamin D deficiency. Early management of Byler Disease is directed at nutritional issues which tend to be responsive to medical intervention, unlike the pruritus/scratching which remains a devastating problem. Progressive liver disease develops in Byler Disease and can lead to cirrhosis and end-stage liver disease. This is an open label expanded access protocol of RAVICTI in children with Byler Disease. The primary hypothesis is that the administration of RAVICTI in these children is feasible, well tolerated and safe. It is also hypothesized that RAVICTI treatment leads to an improvement in biochemical markers of liver disease and it may ameliorates or prevents the development of scratching behavior as a manifestation of pruritus attributed to the liver disease.