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Post-operative Pain clinical trials

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NCT ID: NCT06215820 Recruiting - Pain Clinical Trials

Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Bunionectomy

Start date: December 29, 2023
Phase: Phase 3
Study type: Interventional

MR-107A-02 is being studied to investigate its efficacy and safety for treatment of acute pain after bunionectomy.

NCT ID: NCT06212622 Recruiting - Pain Clinical Trials

Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?

REHAB
Start date: March 4, 2024
Phase:
Study type: Observational

Hip fracture injuries are linked with increased morbidity, frailty, and mortality risk. Studies have shown that in hip fracture surgery, early mobilisation confers better pain control, 30-day complication and mortality rates and could reduce in hospital length of stay. Though early mobilisation may provide numerous post operative benefits, there are barriers to achieving this reliably and effectively. One such difficulty is pain. In the Royal Infirmary of Edinburgh (RIE) like many boards across Scotland, oral oxycodone has been routinely used as analgesia to help with post operative pain, in patients who have undergone orthopaedic trauma injuries. However, this analgesic modality is utilised to help with general post operative pain, rather than targeted abolition of pain prior to physiotherapy. Alfentanil is a relatively new medication which has a very rapid onset of action and short half life. Alfentanil may prove to be a superior form of analgesia for the purpose of encouraging early mobilisation after hip fracture surgery. This study could provide robust evidence for regular use of alfentanil prior to physiotherapy in early post operative hip fracture surgery patients.

NCT ID: NCT06205875 Recruiting - Surgery Clinical Trials

High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery.

Start date: February 21, 2024
Phase: N/A
Study type: Interventional

This study aims to compare the efficacy and quality of pain relief provided by the high-dose serratus anterior plane (SAP) block with the standard SAP block in preventing and treating acute postoperative pain after total endoscopic aortic or mitral valve surgery.

NCT ID: NCT06187909 Recruiting - Analgesia Clinical Trials

US-Guided PECS II Block Versus MTP Block For Postoperative Analgesia Of MRM Sugery

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

This study aims to compare the analgesic efficacies of the modified pectoral plane block (PECS II) and the midpoint transverse process to pleura block (MTP), after modified radical mastectomy (MRM) surgery during the first 24 hour post-operatively by using the Visual Analogue Scale.

NCT ID: NCT06165575 Recruiting - Post-operative Pain Clinical Trials

The Effect of Press Needle in the Combination of Ear and Body Acupuncture Points on Visual Analog Scale in Post-Operative Patients of Open Spine Surgery

Start date: October 13, 2023
Phase: N/A
Study type: Interventional

Postoperative pain is pain that arises after a surgical procedure, resulting from trauma during the surgical incision process. It is generally acute in nature and is accompanied by an inflammatory response. Spinal surgery is a surgical procedure used to address issues typically involving pain in the spinal or back area. Commonly used postoperative analgesics are opioid types administered intravenously. All types of opioids exhibit similar side effects, particularly in terms of respiratory depression, which can lead to hypoxia and respiratory arrest. Other side effects include nausea, vomiting, itching, decreased intestinal motility leading to ileus, and constipation. The press needle acupuncture, a specialized acupuncture needle developed from intradermal needles, is being used. The advantage of the press needle is its minimally invasive nature, relative affordability, safety, and the ability to continuously stimulate acupuncture points for several days, generally without causing serious side effects. This study aims to determine the effectiveness of the combined therapy of press needle acupuncture and medication in treating postoperative pain in patients who have undergone open spinal surgery. The study follows a double-blind randomized clinical trial design and is conducted at the inpatient units of Dr. Cipto Mangunkusumo National General Hospital (Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo), University of Indonesia Hospital (Rumah Sakit Universitas Indonesia), and Fatmawati General Hospital. The research is a collaboration between the Medical Acupuncture Department of Faculty of Medicine at the University of Indonesia and the Orthopedics and Traumatology Department. The study employs press needle acupuncture on 8 acupuncture points, 4 ear acupuncture points, and 4 body acupuncture points. There are three hypothesis for this trial included, first there is a change in the mean pain intensity before the placement of press needles and 24 hours after open spine surgery, following the placement of press needles, in the press needle and medication group at LI4 Hegu, LR3 Taichong, ear acupoint MA TF-1 Shenmen, and MA AT-1 Thalamus compared to the change in mean pain intensity before the placement of sham press needles and 24 hours after open spine surgery, following the placement of sham press needles in the sham press needle and medication group, as measured using the visual analog scale. Second there is a lower mean postoperative pain intensity in the press needle and medication group at LI4 Hegu, LR3 Taichong, ear acupoint MA TF-1 Shenmen, and MA AT-1 Thalamus compared to the sham press needle and medication group, as measured using the visual analog scale at 24 hours and 72 hours after open spine surgery. Third, there is a higher score for postoperative pain management quality in the press needle and medication group at LI4 Hegu, LR3 Taichong, ear point MA TF-1 Shenmen, and MA AT-1 Thalamus compared to the sham press needle and medication group, as assessed using the American Pain Society Patient Outcome Questionnaire Revised questionnaire at 24 hours after open spine surgery The outcome of this research is the intensity of pain scores measured using the visual analog scale assessed prior to press needle acupuncture insertion, 24 hours post-operation, and 72 hours post-operation. Additionally, the quality of postoperative pain management is assessed using the American Pain Society Patient Outcome Questionnaire Revised (APS-POQ-R) at 24 hours post-operation.

NCT ID: NCT06147401 Recruiting - Post Operative Pain Clinical Trials

Comparison of PENG Associated With LFCN Block Versus FICB for Multimodal Analgesic Management in THA

Start date: November 20, 2023
Phase: N/A
Study type: Interventional

Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation. Fascia iliaca compartment block (FIC) has been recommended since it offers the best pain control with low risk of motor block. Pericapsular nerve group block (PENG) with lateral femoral cutaneous block (LFCN) has been proposed as an effective alternative to FIB that offers similar pain control with a considerably lower risk of motor block. The aim of this study is to compare the afore mentioned blocks and determine which one yielded the least degree of quadriceps femoris muscle weakness and the better pain control (the lowest NRS score with least need for opioids).

NCT ID: NCT06123715 Recruiting - Chronic Pain Clinical Trials

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

PROVISION
Start date: April 4, 2024
Phase: Phase 2
Study type: Interventional

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.

NCT ID: NCT06106386 Recruiting - Inflammation Clinical Trials

The Effect of Intraradicular Cryotherapy on Post-operative Pain and the Level of Substance P

Start date: January 18, 2024
Phase: N/A
Study type: Interventional

The aim of this clinical trial is to evaluate the effect of using intra-radicular cryotherapy technique in the form of irrigation with cold sodium hypochlorite The main questions to answer are: 1. Does Postoperative pain is different between the two groups? 2. Does level of substance P different between the two groups ?

NCT ID: NCT06104254 Recruiting - Post Operative Pain Clinical Trials

Education Importance and Pain Belief Differences Among Patients Who Underwent Orthopedic Surgery

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

The assessment of pain plays a crucial role in pain management. Nurses are instrumental in the identification, evaluation, and initiation of pain management strategies. In the literature, it is strongly recommended to provide education about postoperative pain management to patients, their families, and those responsible for patient care. Additionally, the development of a pain management plan and goals is advocated. The optimal timing, content, and objectives of patient education depend on the type of pain (acute or chronic), the availability and effectiveness of treatment, and the patient's level of education and literacy. Educating individuals undergoing elective surgery or outpatient treatment about the likelihood and magnitude of acute pain they may experience, as well as informing them about available methods to prevent or alleviate this pain, is critical for pain management. Shindo et al. conducted a study suggesting that perioperative pain education significantly reduces postoperative opioid use. According to the Health Belief Model, an individual's perception of health is influenced by their perception of the value of health, beliefs about illness, and beliefs about the consequences of illness. Therefore, when a patient's health beliefs and attitudes are determined, health education and treatment planning can be tailored more appropriately.

NCT ID: NCT06088420 Recruiting - Post Operative Pain Clinical Trials

Analgesic Efficacy of Different Nerve Blocks in Postoperative Cesarean Section

Start date: October 2023
Phase: N/A
Study type: Interventional

comparing analgesic efficacy of different nerve blocks on post operative cesarean sections.