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Inflammation clinical trials

View clinical trials related to Inflammation.

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NCT ID: NCT03532763 Recruiting - Inflammation Clinical Trials

Anti-Inflammatory Effect of Tocotrienol Supplementation in Subjects With Moderately Elevated Inflammation

INTOC
Start date: April 19, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to address the anti-inflammatory effect of tocotrienol supplementation in subjects with moderately elevated inflammation. It is hypothesized that 6 months supplementation of tocotrienols will reduce inflammatory markers of subjects.

NCT ID: NCT03531697 Recruiting - Clinical trials for Inflammation Following Ocular Surgery

Study of Loteprednol Etabonate in Adults Undergoing Bilateral Cataract Surgery

Start date: April 26, 2018
Phase: Phase 1
Study type: Interventional

This study will assess the bioequivalence of Loteprednol Etabonate and the reference listed drug (RLD)

NCT ID: NCT03530501 Completed - Inflammation Clinical Trials

Effect of Very-low Calorie Diet and Synbiotic Supplementation in Gut Microbiota (Pronokal Method)

Pronokal
Start date: August 29, 2016
Phase: N/A
Study type: Interventional

The present study aimed to investigate the changes produced in gut microbiota by a very-low-calorie-ketogenic diet followed by a low calorie diet, whether the use of synbiotics is able to modulate gut microbiota diversity and composition and its association with gut permeability and inflammation

NCT ID: NCT03529942 Recruiting - Clinical trials for Osteoarthritis, Knee

Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee

Start date: April 24, 2018
Phase: Phase 3
Study type: Interventional

This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.

NCT ID: NCT03529929 Recruiting - Aging Clinical Trials

Glucocorticoid Inflammation Paradox in Human Skeletal Muscle

Start date: June 1, 2018
Phase: Phase 3
Study type: Interventional

In this project, we propose to investigate the metabolic consequences of glucocorticoid therapy, given orally as a 6 day Medrol Dose pack, on human skeletal muscle as measured by western blotting and PCR and skeletal muscle mitochondrial capacity as measured by High-Resolution Respirometry in healthy individuals. Medrol is an FDA approved drug with many clinical indications.

NCT ID: NCT03529344 Active, not recruiting - Inflammation Clinical Trials

A Study on the Effects on Glucose Regulation, Inflammation and Serum Lipids After Fish Protein Supplementation in Elderly (GRIPE)

GRIPE
Start date: August 2016
Phase: N/A
Study type: Interventional

The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population. These age-related changes in muscle function may be explained by chronic low-grade inflammation and insulin resistance. Despite the recommendation of a higher protein intake, little is known about how different protein sources may affect the metabolic health in this population. Analysis of amino acid composition show that fish can be a good protein source for humans. Many fish species are today used as feed ingredients, rather than a protein source for humans. A few studies conducted in humans and rats show that proteins from fish may improve glucose tolerance, reduce inflammation and improve lipid metabolism, indicating that proteins from fish may not only serve as a valuable nutrient but could also hold specific health promoting properties. The present study will investigate the effects of a protein hydrolysate from blue whiting, a fish species normally used to produce fish meal for aquaculture industry, on glucose homeostasis, inflammation and serum lipids in elderly nursing home residents.

NCT ID: NCT03526913 Completed - Clinical trials for Chronic Venous Hypertension With Ulcer and Inflammation

Role of Platelet Rich Plasma in Enhancing Graft Take in Chronic Venous Ulcers

Start date: February 1, 2016
Phase: N/A
Study type: Interventional

Chronic venous ulcers are considered a problem with a big morbidity impact on both the health facilities and patients, skin-grafting have shown not so perfect outcomes with such ulcers. In this study, the investigators compare combining autologous platelet rich plasma treatments with partial skin grafting in chronic ulcers, the results were compared to using only partial skin grafting, and among various types of chronic resistant ulcers.

NCT ID: NCT03525639 Recruiting - Clinical trials for Myocardial Inflammation

CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance

MIAMI
Start date: December 6, 2016
Phase: N/A
Study type: Interventional

Patients with acute myocarditis (AM) usually experience spontaneous healing, but a considerable percentage of them evolve toward chronic cardiac impairment at long-term. The evolution toward dilated cardiomypathy (DCM) occurs in a subtle manner, frequently after an initial recover that mimics complete healing. Differences in the course of disease may reflect the course of underlying myocardial inflammation related to viral clearance or persistence and to the following autoimmunity response. New cardiac magnetic resonance (CMR) parameters are sensitive to myocardial inflammation. They may have a prognostic role and, in particular, our hypothesis is that a short-term monitoring with CMR (1 month) may identify the subgroup of patients at high risk to progress toward DCM. The trend of CMR parameters during the first month will be compared with the following outcome in 80 patients with AM. Results of this study will help to significantly improve management and outcome of patients with AM.

NCT ID: NCT03524690 Not yet recruiting - Inflammation Clinical Trials

Effects of Severe Negative Energy Balance on Inflammation

Start date: October 2018
Phase: N/A
Study type: Interventional

The effects of prolonged negative energy balance, commonly observed in sustained military training and combat operations, on systemic inflammatory responses has not been determined. To define the putative role of energy balance on inflammation and its downstream effects, we will conduct a controlled laboratory study that simulates extensive physiological stressors to determine if inflammation is exacerbated by underfeeding. This design will test the hypothesis that maintaining energy balance will attenuate systemic inflammation and its potential negative effects on whole-body metabolic homeostasis in response to physiological stressors.

NCT ID: NCT03523767 Recruiting - Clinical trials for Major Depressive Disorder

Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study

Start date: February 7, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this pilot study is to investigate and compare the effect of a mild inflammatory stimulus (typhoid vaccine) on immune response, mood and cognition in healthy volunteers compared to patients with history Major Depressive Disorder (MDD) (not currently depressed and no symptoms of depression in the past 6 months).