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Osteoporosis clinical trials

View clinical trials related to Osteoporosis.

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NCT ID: NCT03006003 Not yet recruiting - Depressive Syndrome Clinical Trials

Osteoporosis Treatment in Post-menopausal Women

Start date: December 2016
Phase: Phase 4
Study type: Interventional

The study will be conducted to assess the depressive symptoms and related markers in the postmenopausal female after anti-osteoporosis treatment.

NCT ID: NCT03005678 Not yet recruiting - Osteoporosis Clinical Trials

Denosumab Versus Bisphosphonates (Alendronate) in GIOP

Start date: April 2017
Phase: Phase 4
Study type: Interventional

A randomized controlled trial to compare for the efficacy and tolerability of denosumab and oral alendronate in the management of glucocorticoid induced osteoporosis

NCT ID: NCT03002428 Recruiting - Osteoporosis Clinical Trials

A Comparison of PF708 and Forteo in Osteoporosis Patients

Start date: December 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effects of two teriparatide products, PF708 and Forteo, in patients with osteoporosis.

NCT ID: NCT02981732 Active, not recruiting - Clinical trials for Postmenopausal Osteoporosis

CLCF1 Gene Associated With Postmenopausal Osteoporosis of Kidney Yin Deficiency Syndrome

PMOP
Start date: October 2016
Phase: N/A
Study type: Interventional

For nearly 112 million patients with osteoporosis in China, it is of great significance for preventing and treating by clearly understanding the molecular mechanism of kidney deficiency. Thus, the research group has demonstrated in the earlier research that CLCF1 is an associated gene that can regulate JAK2/STAT3 signal pathway and impact bone metabolism for kidney yin deficiency of postmenopausal osteoporosis (PMOP). To make clear understanding of the direct-acting mechanism of CLCF1 for bone metabolism, this study intends to: ①observe impacts of low expression of CLCF1 upon immunities in mice and OPG/RANKL/RANK signal system using the technology of adenovirus associated virus. ②explore impacts of over-expression and silencing of CLCF1 on B lymphocytes by culcuturing the cells together with osteoblasts. ③ analyze the impacts of treating kidney yin deficiency of PMOP by Liuwei Dihuang pill upon immunities and OPG/RANKL/RANK system, and discuss the mechanism of regulating bone metabolism by CLCF1 by OPG/RANKL/RANK system via the bridge between immune system and bone metabolism, so as to demonstrate if the hypothesis of this study that "the molecular osteoimmunological mechanism of kidney yin deficiency of postmenopausal osteoporosis (PMOP) is possibly closely related to the impacts of CLCF1 regulation of OPG/RANKL/RANK signal system on bone metabolism" is right or not.

NCT ID: NCT02977949 Recruiting - Clinical trials for Selective Estrogen Receptor Modulator (SERM)

The Effects of Seasonal Changes in Osteoporosis Treatment

Start date: January 2012
Phase: N/A
Study type: Observational [Patient Registry]

There are few reports concerning to the seasonal variation of osteoporosis treatment. In this study, we plan to compare clinical efficacy and safety by seasons.

NCT ID: NCT02967978 Not yet recruiting - Osteoporosis Clinical Trials

Study on the Predictive Value of the Natural Calcium Isotope Ratio in Urine and Serum for the Diagnosis of Osteoporosis

Start date: November 2016
Phase: N/A
Study type: Observational

The study aims at investigating whether the natural calcium isotope ratio (δ44/40Ca) in urine and serum differs between postmenopausal women aged 50 to 75 years suffering from osteoporosis and a healthy control group and whether δ44/40Ca in urine and serum can be used for the diagnosis of osteoporosis or whether further parameters have to be included.

NCT ID: NCT02958020 Not yet recruiting - Osteoporosis Clinical Trials

Multicenter Cohort Study on Osteoporosis

Start date: November 2016
Phase: N/A
Study type: Observational

This is a multicenter cohort study on osteoporosis in six cities of China which locate in the east, south, north, west, middle of China respectively. At least 3000 middle-aged and elderly permanent residents (women aged from 45 to 79, and men aged from 50 to 79) in every city were enrolled. Residents with severe mental diseases, physical diseases or acute infectious diseases who could not cooperate with the survey as well as lactating or pregnant women were excluded. All the enrolled residents who signed informed consent will finish questionnaire including demographic characteristics, history of smoking, alcohol drinking, falls and fracture, family, chronic diseases and medicine,diary and physical practice. Osteoporosis risk, health status (EQ-5D) and constitution of traditional Chinese medicine (TCM) will be evaluated. Fasting blood tests, bone mineral density and physical examinations (height, weight, waist circumference, hip circumference,grip,sit-to-stand test, tongue coating and pulse) will be performed at enrollment and every two years after enrollment. DNA of blood cells will be preserved.

NCT ID: NCT02948881 Completed - Osteoporosis Clinical Trials

A Study To Assess The Quality Of Bone In Patients Taking Oral Ibandronate Versus Placebo

Start date: August 2005
Phase: Phase 4
Study type: Interventional

The purpose of this study is to estimate the effect of oral Boniva (ibandronate sodium)taken once monthly versus placebo on bone quality and strength at the hip at one year.

NCT ID: NCT02946424 Not yet recruiting - Osteoporosis Clinical Trials

Simvastatin to Prevent SCI-Induced Bone Loss

Start date: November 2016
Phase: Phase 2
Study type: Interventional

This is a double blind, randomized, placebo -controlled clinical trial with the primary goal of determining the osteogenic benefits of simvastatin in acute SCI.

NCT ID: NCT02944799 Recruiting - Clinical trials for Rheumatoid Arthritis

Alendronate Treatment of Osteoporosis in Rheumatoid Arthritis

ALOSTRA
Start date: December 2015
Phase: Phase 2
Study type: Interventional

A randomized, double-blind, placebo-controlled trial including 160 consecutive patients who have been diagnosed with both rheumatoid arthritis (RA) and osteoporosis and have been treated with alendronate (ALN) for five years or more. Patients will be randomized to discontinuation or continuation of alendronate. Outcomes are measured using dual energy absorptiometry (DXA), High Resolution peripheral Quantitative Computer Tomography (HR-pQCT) and biochemical markers of bone metabolism and inflammation after 6 months, 1 and 2 years.