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Osteoporosis clinical trials

View clinical trials related to Osteoporosis.

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NCT ID: NCT02931305 Recruiting - Clinical trials for Cardiovascular Disease

Epimedium Prenylflavonoid (EP) Extract for Osteoporosis and Cardiovascular Disease

Start date: October 2016
Phase: Phase 1
Study type: Interventional

The primary objective of the trial is to develop Epimedium Prenylflavonoid (EP) extract as a pharmaceutical-quality intervention for post-menopausal osteoporosis and cardiovascular disease. There will be 3 cohorts of 10 healthy men each for the Phase 1 study. In each cohort, 8 men will receive the Epimedium capsules and 2 men will received the matched controls.

NCT ID: NCT02928666 Not yet recruiting - Hypertension Clinical Trials

Integration of Guidelines for Comorbidities

Start date: October 2018
Phase: N/A
Study type: Interventional

Introduction: in the course of the research, the investigators will develop a decision-support system (comorbidity-DSS) consisting (1) a knowledge base (KB) consisting of (a) computer-interpretable clinical guidelines for type 2 diabetes and 2 other diseases from: obstructive pulmonary disease, osteoporosis, hypertension, and osteoarthritis; and (b) an ontology of relevant general medical knowledge that could complement (a) in order to propose non conflicting treatment options not mentioned in the clinical practice guidelines; and (2) an algorithm that matches the KB with a patient's data set to identify the guidelines-based recommendations applicable for the patient and their interactions and which proposes ways to mitigate conflicting interactions (e.g., suggesting to select intervention A.2 (instead of A.1) from guideline A and intervention B.3 (instead of B.1) from guideline B together with an action B' mentioned in the general medical knowledge, because these interventions are not conflicting yet A.3 fulfills the same goals as intervention A.1 and intervention B.3 + B' together fulfill the same goal as B.1). Research purpose: Assessing the correctness and completeness of detection of recommendation-interaction and generation of conflict-free recommendations by a comorbidity-DSS Research question: How will the usage of the comorbidity-DSS affect the completeness and correctness of clinicians regarding (a) detection of interactions between recommendations originating from different clinical guidelines applicable for patients with comorbidities and (b) identification of interventions that fulfill the guidelines' goals and are not conflicting.

NCT ID: NCT02924545 Completed - Osteoporosis Clinical Trials

Evaluation of Osteoporosis Support After a Severe Osteoporotic Fracture in Women Over 50 Years in University Hospital

Start date: January 2015
Phase: N/A
Study type: Observational

Evaluate the support of osteoporosis in women over 50 years with severe osteoporotic fractures (hip, vertebral, rib, Humeral, pelvic fractures) in the Nîmes University Hospital taking prediction of treatment of osteoporosis as criterion.

NCT ID: NCT02922478 Active, not recruiting - Heart Failure Clinical Trials

Role of Comorbidities in Chronic Heart Failure Study

Start date: September 2016
Phase: N/A
Study type: Observational [Patient Registry]

This study aims to create a database of patients with stable and chronic heart failure with comprehensive assessment of bone, skeletal and vascular status. RoC-HF will facilitate cross-sectional and, eventually, longitudinal mechanistic epidemiological analyses to disentangle the role of the bone- vascular axis in chronic heart failure. Blood and urine samples will be stored to facilitate future biomarker analyses.

NCT ID: NCT02916862 Not yet recruiting - Osteoporosis Clinical Trials

Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents

Start date: January 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The primary aim of this proposal is to determine the effects of soluble corn fiber (SCF) supplementation for 1 year on bone metabolism in growing adolescents compared to controls. For the proposed study, a randomized double-blinded placebo controlled clinical trial will be conducted in 168 healthy adolescents aged 11-14 years, equally randomly assigned to one of three intervention groups: SCF (12 g/d, administered twice a day), SCF + calcium (12 g/d of SCF + 600 mg/d of elemental calcium carbonate, twice a day), or placebo (0 g/d of SCF or calcium, administered twice a day). Bone metabolism and bone related biomarkers will be assessed at baseline and at 12 months.

NCT ID: NCT02900586 Recruiting - Osteoporosis Clinical Trials

Behavior and Knowledges of Patients Enrolled Into SIOUX Study

Start date: May 2016
Phase: N/A
Study type: Observational

The purpose of this study is to contribute to the evaluation of SIOUX study by adding data about the choices of the observant patients, the mis-observant ones or the protocol deviations.

NCT ID: NCT02892188 Active, not recruiting - Osteoporosis Clinical Trials

Physician-Pharmacist Collaboration for Osteoporotic Patient Follow-up

Start date: January 2013
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the follow-up of the osteoporotic patient by a physician-pharmacist collaboration.

NCT ID: NCT02891356 Recruiting - Osteoporosis Clinical Trials

Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years

Start date: July 2013
Phase: N/A
Study type: Observational

The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years. We assess blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

NCT ID: NCT02884401 Recruiting - Clinical trials for Osteoporosis, Postmenopausal

Peri-implant Bone Changes in Post-menopausal Osteoporotic Women

Start date: June 2016
Phase: Phase 4
Study type: Interventional

This is a prospective case series study aiming to evaluate the effect of post-menopausal osteoporosis on the jaw bone around dental implants with a modified titanium surface. The study consists of 8 visits that will be performed within a minimum period of 15 months. Participants will be recruited from the Rheumatology Department and Radiology Department at Barts Health National Health Service (NHS) Trust. Participants will include 20 post-menopausal osteoporotic women with a requirement of a tooth to be replaced. The main objective of this study is to radiographically compare alveolar (jaw) bone changes in width and height after the placement of a dental implant with a hydrophilic (SLActive) surface and 12 months after loading (placement of the crown) it in post-menopausal osteoporotic women.

NCT ID: NCT02861989 Active, not recruiting - Osteoporosis Clinical Trials

Qualitative Study on Osteoporosis Representation and Management in the General Population and in General Practitioners.

Start date: February 2014
Phase: N/A
Study type: Observational

Osteoporosis (OP) and subsequent fractures (OP fractures) are a source of morbidity and high mortality in the elderly. Despite numerous programs aiming at improving OP care, the prevention, diagnostic and treatment remain suboptimal. Barriers to a better care are multiple, both in the general and at-risk population, and in medical practitioners. Since they do not perceive their susceptibility to OP, people do not see the benefit of prevention. In addition, physicians do not give sufficient importance to OP prevention and care, despite the existence of guidelines. The investigators implemented a qualitative study to explore the knowledge and representations regarding osteoporosis in the general and at-risk population and in doctors in Rhône-Alpes Region, France, using focus groups with women and men and semi-structured face-to-face interviews with general practitioners. Understanding barriers to osteoporosis care in patients and general practitioners will help to set up effective strategies to improve prevention and treatment.