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Osteoporosis clinical trials

View clinical trials related to Osteoporosis.

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NCT ID: NCT03251430 Recruiting - Osteoporosis Clinical Trials

Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy

Start date: August 20, 2017
Phase: N/A
Study type: Observational [Patient Registry]

Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The aim of the present study was to evaluate osteoporosis by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in the long course after gastrectomy. In total gastrectomy and distal gastrectomy groups, at least 5 years should have elapsed since gastrectomy.

NCT ID: NCT03242512 Not yet recruiting - Osteoporosis Clinical Trials

Assessment of Anti-RANKL Antibody in Post-menopausal Women

Start date: August 12, 2017
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a fully human monoclonal antibody of receptor activator for nuclear factor-κ B ligand (RNAKL) (code name: TK006) in postmenopausal women.

NCT ID: NCT03234244 Active, not recruiting - Osteoporosis Clinical Trials

HDDO-1614 Intervention Trial

Start date: April 12, 2017
Phase: Phase 1
Study type: Interventional

Randomized, Open-label, Single-dose, 3-period, 6-sequence, 3-way crossover Study

NCT ID: NCT03232476 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Effect of Mechanical Loading With PTH on Cortical Bone

Start date: September 2017
Phase: Phase 4
Study type: Interventional

Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.

NCT ID: NCT03225703 Recruiting - Clinical trials for Osteoarthritis, Knee

The Effect of High Impact Exercise on Bone and Articular Cartilage in Post-menopausal Women

Start date: January 2017
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) and osteoporosis (OP) affect large numbers of the population. Around 8 million people in the UK are affected by OA and over 300,000 people present with fragility fractures in the UK each year. High impact exercise has been shown to improve markers of bone health but the effect of this exercise on the cartilage is less well understood. A six month, one leg, exercise program based on hopping will be carried out by a group of post-menopausal women. Post-menopausal women are particularly at risk from OP and the research should give information on the feasibility of this type of exercise program in this age group and the effect on cartilage. Participants will be aged between 55 and 70 (at least five years post menopause) with no conditions that would limit their ability to complete the exercise program. To assess changes in participants' cartilage and bone properties they will be asked to attend several meetings at Loughborough University. Before and after the exercise program participants will have bone density scans and MRI scans of the knee joint. A subset (n=4) will undergo high resolution bone scans that can demonstrate changes in bone structure. The intervention is a home based exercise programme lasting approximately 10 minutes per day. Initially this will be individualised to each participant with the end goal being daily exercise sessions. The programme will last for six months with supervised sessions offered throughout the trial. Using an intervention affecting just one leg will allow the research team to use the other leg as a control. The research team hypothesise that in a population of post-menopausal women, a six month, unilateral exercise intervention will improve bone mineral density at the proximal femur with no negative effects on articular cartilage.

NCT ID: NCT03225040 Recruiting - Acromegaly Clinical Trials

Bone MicroArchitecture in Acromegaly

Start date: August 3, 2016
Phase: N/A
Study type: Observational

The investigators will conduct a cross-sectional study of bone density, bone microarchitecture, vertebral fractures and trabecular bone score in 25 patients with acromegaly treated with Pegvisomant, the growth hormone (GH) receptor antagonist for at least 1 year and with normal insulin-like growth factor-1 (IGF-1) levels. This study aims to describe the bone architecture and associated biochemical indices of bone turnover and metabolism in patients with active acromegaly and how these are altered with treatment of the disease.

NCT ID: NCT03219099 Not yet recruiting - Osteoporosis Clinical Trials

Normative Database for HR-pQCT-Based Radius and Tibia Strength

NODARATIS
Start date: August 14, 2017
Phase: N/A
Study type: Observational

A novel methodology was recently developed and validated by the applicants to compute bone strength at the distal radius and tibia using second-generation HR-pQCT reconstructions. The methodology is expected to improve significantly the assessment of bone fracture risk in idiopathic and secondary osteoporosis, but no reference data and no reproducibility data are available. The objective of the study is the determination of the sex- and age-specific distributions of accurate distal radius and tibia strength assessed by HR-pQCT in the Swiss population.

NCT ID: NCT03217513 Not yet recruiting - Osteoporosis Clinical Trials

Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis

Start date: September 1, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to generate proof of concept human data by evaluating osteoarthritis outcome measures in arthritic patients that are prescribed Forteo® as the standard of care to treat their primary diagnosis of osteoporosis.

NCT ID: NCT03201016 Recruiting - Osteoporosis Clinical Trials

Prevalence of Osteoporosis and Fractures in Patients With Hepatic Cirrhosis and Investigation of the Associated Factors

POC
Start date: June 2016
Phase: N/A
Study type: Observational [Patient Registry]

Osteoporosis is a common complication in chronic liver disease, especially in the late stages of the disease. Good nutrition and calcium and vitamin D supplementation are recommended for the prevention and treatment of osteoporosis. There are no specific guidelines for its pharmacological treatment, but bisphosphonates have been shown to be effective in increasing bone mass in patients with chronic cholestasis, with a good safety profile. There are few studies evaluating the prevalence of osteoporosis in patients with cirrhosis (except for primary biliary cholangitis (PBC)). There are no clear recommendations for osteoporosis screening in cirrhotic patients. A diagnosis and early therapeutic intervention before the onset of the complications derived would significantly improve the quality of life and decrease the morbidity and mortality associated with osteoporosis and fractures Objective: -To assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis in our country and the risk factors associated Method: Patients diagnosed with hepatic cirrhosis, other than PBC, will be included in any Child stage during a hospital admission. Epidemiological, demographic, clinical, analytical and imaging data (dorso-lumbar spine radiography, bone densitometry and Trabecular Bone Score) will be evaluated. A descriptive statistic of the main variables will be carried out as well as a multivariate analysis to evaluate the predictive factors of osteoporosis and / or fragility fractures

NCT ID: NCT03197623 Recruiting - Osteoporosis Clinical Trials

Safety and Tolerability of Intravenous LLP2A-Alendronate for Osteopenia Secondary to Glucocorticoids

Start date: October 14, 2016
Phase: Phase 1
Study type: Interventional

A Phase 1 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women with Osteopenia Secondary to Corticosteroids.