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Osteoporosis clinical trials

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NCT ID: NCT03301285 Completed - Osteoporosis Clinical Trials

Efficacy of Zoledronic Acid in Osteoporosis of Children With Multiple Disabilities

Start date: January 1, 2017
Phase: N/A
Study type: Observational

The main purpose of this study is the evaluation of the efficacy of zoledronic acid on bone density in children with osteoporosis caused by multiple disabilities. Secondary purposes are: 1. Description of child population with osteoporosis in the context of motor impairment in Lorraine region 2. Description of osteoporosis stage (level of bone mineralization and clinical consequences) in children with multiple disabilities 3. Description of current osteoporosis preventive care 4. Description of risk factors associated to bone status (drugs) 5. Evaluation of zoledronic acid treatment on fracture numbers 6. Evaluation of zoledronic acid on phosphocalcic profile 7. Description of side effects of zoledronic acid in this indication 8. Description of treatment effects in the sub-population of children with Rett syndrome.

NCT ID: NCT03280693 Completed - Osteoporosis Clinical Trials

Relationships Among Body Mass Index, Body Balance and Bone Mineral Density in Postmenopausal Women

Start date: May 2015
Phase: N/A
Study type: Observational

Body composition, bone mineral density (BMD), and body balance are important factors that threaten postural control. They act as vital elements in the vicious circle that leads to fracture occurrence in elderly population, particularly postmenopausal women.

NCT ID: NCT03263585 Completed - Osteoporosis Clinical Trials

Treatment With a Spinal Orthosis Compared to Equipment Group Training and a Control Group

Start date: May 3, 2012
Phase: N/A
Study type: Interventional

Background: Back pain and osteoporosis with vertebral fractures are common conditions in elderly women and significantly affect their quality of life. A common complication of osteoporosis are vertebral fractures. Treatment with bone-specific drugs does often not help the pain condition caused by the vertebral fractures even when the progress of the disease has decreased. Vertebral fractures often result in deformation of the spine and poorer quality of life of the individual. The spinal kyphosis also affects the lung function and the effect of the kyphosis itself is severe. Alternative treatments of back pain may lead to reduced drug demand for pain. Physical activity is one of the most important factors that regulates bone mass and can also affect balance and fall risk positively. The back orthosis that we intend to use in the treatment study has been shown in some previous scientific studies to strengthen the muscles in the back and also decrease the pain. Purpose: The purpose of the study was to evaluate the effect of treatment of back pain in elderly women with an activating functional orthosis versus treatment with a group of physiotherapeutic tools and a control group for a six-month treatment period and follow-up after 12 months from the start of study. The aim was also to study elderly women with osteoporosis and back pain in a follow-up study of a cohort of women at high risk of osteoporotic fractures, with focus on back pain, functional capacity and quality of life. The aim was to study the effect of treatment with activating functional orthosis versus physiotherapeutic treatment in a group and a control group without treatment. The main outcomes will be the experienced perceived back pain and back extensor strength. Additional outcomes will be quality of life, balance, lung function and kyphosis. Biochemical markers for pain will be measured in the RCT (Randomized Controlled Trial). Significance: Evaluation of alternative treatment methods such as exercise by a physiotherapist and treatment with a functional orthosis will give new additional treatment options for our patients. An activating functional orthosis could reduce the use of analgesics and increase the quality of life of the affected women.

NCT ID: NCT03127293 Completed - Clinical trials for Hyperemesis Gravidarum

Hyperemesis Gravidarum and Osteoporosis

Start date: January 1, 2015
Phase: N/A
Study type: Observational

Hyperemesis Gravidarum (HG) is a common disorder for hospitalization in the first trimester of pregnancy and related to protracted vomiting and nausea. It can be accompanied by ketonuria, dehydration and weight loss. Our aim was to investigate osteoporosis in patients with HG. In our study, we investigated osteoporosis in a total of 79 patients (40 HG and 39 control) by means of dual energy x-ray absorptiometry (DEXA) measurements and laboratory parameters related to HG.

NCT ID: NCT03125590 Completed - Osteopenia Clinical Trials

Validation, Reliability and Pilot Test of the Personalized Exercise Questionnaire (PEQ)

Start date: April 1, 2017
Phase: N/A
Study type: Observational

The PEQ is the first tool to measure facilitators, barriers, and preferences to exercise in people with osteoporosis.

NCT ID: NCT03091088 Completed - Physical Activity Clinical Trials

Effects of Physical Exercise to Prevent Osteoporosis in Postmenopausal Women

Start date: February 1, 2011
Phase: N/A
Study type: Interventional

According to the World Health Organization criteria, osteoporosis was defined as a bone mineral density that lies 2.5 standard deviations or more below the average value for young healthy women. Osteoporosis is a major cause of fractures and can lead to serious complications in postmenopausal women. For this reason, approaches to prevent the appearance and progression of osteoporosis are of primary importance. This randomized clinical trial analyzes the effects of two types of physical exercise oriented to prevent osteoporosis in postmenopausal women with pharmacological supplements of Calcium and Vitamin-D.

NCT ID: NCT03026660 Completed - Clinical trials for Postmenopausal Osteoporosis

Moringa Oleifera on Bone Density

Start date: July 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effects of Moringa Oleifera on the structure and function of bone in post-menopausal women ingesting 1000 mg of Moringa Oleifera daily for 12 weeks.

NCT ID: NCT02948881 Completed - Osteoporosis Clinical Trials

A Study To Assess The Quality Of Bone In Patients Taking Oral Ibandronate Versus Placebo

Start date: August 2005
Phase: Phase 4
Study type: Interventional

The purpose of this study is to estimate the effect of oral Boniva (ibandronate sodium)taken once monthly versus placebo on bone quality and strength at the hip at one year.

NCT ID: NCT02924545 Completed - Osteoporosis Clinical Trials

Evaluation of Osteoporosis Support After a Severe Osteoporotic Fracture in Women Over 50 Years in University Hospital

Start date: January 2015
Phase: N/A
Study type: Observational

Evaluate the support of osteoporosis in women over 50 years with severe osteoporotic fractures (hip, vertebral, rib, Humeral, pelvic fractures) in the Nîmes University Hospital taking prediction of treatment of osteoporosis as criterion.

NCT ID: NCT02808988 Completed - Clinical trials for Chronic Periodontitis

Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis

Start date: October 2013
Phase: Phase 4
Study type: Interventional

The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients with osteoporosis under bisphosphonate therapy within 12 months' follow-up. Clinical recordings and GCF were obtained from postmenopausal women; with chronic periodontitis and osteoporosis (Group A, n=13), with chronic periodontitis and no osteoporosis (Group B, n=12), without chronic periodontitis and osteoporosis (Group C, n=12), systemically and periodontally healthy controls (Group D, n=10) at the baseline. Recordings were repeated at the 1st, 6th and 12th months in Group A, B and C. RANKL and OPG values were measured by enzyme-linked immunosorbent assays.