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Osteoporosis clinical trials

View clinical trials related to Osteoporosis.

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NCT ID: NCT03359317 Not yet recruiting - Osteoporosis Clinical Trials

Jogging in the Change of Osteoporosis

Start date: February 20, 2018
Phase: N/A
Study type: Interventional

To test the changes in osteoarthritis according to the X-rays, and changes in bone quality before and 1 or more years after beginning the jogging

NCT ID: NCT03331536 Not yet recruiting - Osteoporosis Clinical Trials

Skeletal Health in Bariatric Surgery Patients

Start date: December 1, 2017
Phase: N/A
Study type: Observational

The investigators propose a prospective cohort trial that will help to understand the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal female bariatric patients.

NCT ID: NCT03330340 Not yet recruiting - Osteoporosis Clinical Trials

Percutaneous Vertebroplasty Versus Conservative Treatment in GIOPVCF

Start date: December 1, 2017
Phase: N/A
Study type: Observational

Based on the case reports and other literature, the investigators hypothesize that using PVP for treating GIOPVCF is associated with increased risk of vertebral refractures and does not provide further benefits compared to conservative treatments. The overall objective of this prospective cohort study is to compare the efficacy of PVP and conservative treatment for GIOPVCF. The evaluation of efficacy of therapy includes: 1) the incidence of vertebral refractures; 2) therapeutic effects (pain relief and health-related life quality) and 3) complications. The results from study will be written in English and disseminated widely through scholarly presentations, peer-reviewed publications, and other written communications.

NCT ID: NCT03304743 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Dental Panoramic Radiographs to Screen for Post-menopausal Osteoporosis

OsteoPano
Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Osteoporosis is a common disease that makes the bones fragile and easy to break. Osteoporotic fractures are a serious health problem resulting in pain, reduced mobility, increasing degree of dependence and sometimes death. Osteoporosis is currently diagnosed by measuring bone density at the hip/spine through an exam called DXA. Although all post-menopausal women are at higher risk, currently Italian national guidelines do not recommend population-screening programs. This leads to several cases not being identified before a fracture occurs. Since dental panoramic radiographs (OPGs) are common procedures during dental check-ups or before dental treatments, it would be of great value if dentists could use them to identify people with unknown osteoporosis and early refer them to a specialist before they fracture. This study aims to test if it is meaningful to use OPGs to screen for post-menopausal osteoporosis. In particular, it will inform on how many undiagnosed osteoporotic women attend a Dental Hospital, how willing they are to have a DXA scan after a dental appointment and how precise the OPGs are as screening tools. 124 post-menopausal women will be recruited, which will undergo an OPG and a DXA scan to check their bone density.

NCT ID: NCT03294057 Not yet recruiting - Osteoporosis Clinical Trials

Collaborative Care With Smart Health Management Program for Patients With Chronic Illness

Start date: October 11, 2017
Phase: N/A
Study type: Interventional

This study verifies efficacy of collaborative care with Smart Health Management Program developed for patients with chronic illness. The aim of the study is to observe the changes in clinical indicators, quality of life and health related behaviors when providing self-management programs with ICT for chronic disease patients.

NCT ID: NCT03242512 Not yet recruiting - Osteoporosis Clinical Trials

Assessment of Anti-RANKL Antibody in Post-menopausal Women

Start date: September 1, 2017
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a fully human monoclonal antibody of receptor activator for nuclear factor-κ B ligand (RNAKL) (code name: TK006) in postmenopausal women.

NCT ID: NCT03232476 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Effect of Mechanical Loading With PTH on Cortical Bone

Start date: September 2017
Phase: Phase 4
Study type: Interventional

Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.

NCT ID: NCT03219099 Not yet recruiting - Osteoporosis Clinical Trials

Normative Database for HR-pQCT-Based Radius and Tibia Strength

NODARATIS
Start date: August 14, 2017
Phase: N/A
Study type: Observational

A novel methodology was recently developed and validated by the applicants to compute bone strength at the distal radius and tibia using second-generation HR-pQCT reconstructions. The methodology is expected to improve significantly the assessment of bone fracture risk in idiopathic and secondary osteoporosis, but no reference data and no reproducibility data are available. The objective of the study is the determination of the sex- and age-specific distributions of accurate distal radius and tibia strength assessed by HR-pQCT in the Swiss population.

NCT ID: NCT03175874 Not yet recruiting - Osteoporosis Clinical Trials

Autophagy and Pathological Aging

AVP
Start date: June 2017
Phase: N/A
Study type: Interventional

Autophagy is recognized as a central mechanism for the regulation of aging. . Osteoporosis (OA) and Alzheimer's disease (AD) are two forms of pathological aging, sometimes entangled, including an over-risk of OP in AD and degradation of cognitive functions after OP fracture, but the link between These two pathologies remain poorly understood. The aim of this prospective pilot study is to evaluate the level of autophagy of osteocytes (OST) in postmenopausal women with OP and to explore the hypothesis that the defect of autophagy is one of the physiopathological links of the OP During the MA

NCT ID: NCT03164928 Not yet recruiting - Clinical trials for Glucocorticoid-induced Osteoporosis

Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis

Start date: January 18, 2018
Phase: Phase 3
Study type: Interventional

To evaluate the effect of denosumab on lumbar spine bone mineral density (BMD) Z-score as assessed by dual-energy X-ray absorptiometry (DXA) at 12 months in children 5 to 17 year of age with Glucocorticoid (GC)-induced osteoporosis (GiOP).