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Osteoporosis clinical trials

View clinical trials related to Osteoporosis.

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NCT ID: NCT03304743 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Dental Panoramic Radiographs to Screen for Post-menopausal Osteoporosis

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Osteoporosis is a common disease that makes the bones fragile and easy to break. Osteoporotic fractures are a serious health problem resulting in pain, reduced mobility, increasing degree of dependence and sometimes death. Osteoporosis is currently diagnosed by measuring bone density at the hip/spine through an exam called DXA. Although all post-menopausal women are at higher risk, currently Italian national guidelines do not recommend population-screening programs. This leads to several cases not being identified before a fracture occurs. Since dental panoramic radiographs (OPGs) are common procedures during dental check-ups or before dental treatments, it would be of great value if dentists could use them to identify people with unknown osteoporosis and early refer them to a specialist before they fracture. This study aims to test if it is meaningful to use OPGs to screen for post-menopausal osteoporosis. In particular, it will inform on how many undiagnosed osteoporotic women attend a Dental Hospital, how willing they are to have a DXA scan after a dental appointment and how precise the OPGs are as screening tools. 124 post-menopausal women will be recruited, which will undergo an OPG and a DXA scan to check their bone density.

NCT ID: NCT03294057 Not yet recruiting - Osteoporosis Clinical Trials

Collaborative Care With Smart Health Management Program for Patients With Chronic Illness

Start date: October 11, 2017
Phase: N/A
Study type: Interventional

This study verifies efficacy of collaborative care with Smart Health Management Program developed for patients with chronic illness. The aim of the study is to observe the changes in clinical indicators, quality of life and health related behaviors when providing self-management programs with ICT for chronic disease patients.

NCT ID: NCT03242512 Not yet recruiting - Osteoporosis Clinical Trials

Assessment of Anti-RANKL Antibody in Post-menopausal Women

Start date: September 1, 2017
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a fully human monoclonal antibody of receptor activator for nuclear factor-κ B ligand (RNAKL) (code name: TK006) in postmenopausal women.

NCT ID: NCT03232476 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Effect of Mechanical Loading With PTH on Cortical Bone

Start date: September 2017
Phase: Phase 4
Study type: Interventional

Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.

NCT ID: NCT03219099 Not yet recruiting - Osteoporosis Clinical Trials

Normative Database for HR-pQCT-Based Radius and Tibia Strength

Start date: August 14, 2017
Phase: N/A
Study type: Observational

A novel methodology was recently developed and validated by the applicants to compute bone strength at the distal radius and tibia using second-generation HR-pQCT reconstructions. The methodology is expected to improve significantly the assessment of bone fracture risk in idiopathic and secondary osteoporosis, but no reference data and no reproducibility data are available. The objective of the study is the determination of the sex- and age-specific distributions of accurate distal radius and tibia strength assessed by HR-pQCT in the Swiss population.

NCT ID: NCT03217513 Not yet recruiting - Osteoporosis Clinical Trials

Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis

Start date: September 1, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to generate proof of concept human data by evaluating osteoarthritis outcome measures in arthritic patients that are prescribed Forteo® as the standard of care to treat their primary diagnosis of osteoporosis.

NCT ID: NCT03175874 Not yet recruiting - Osteoporosis Clinical Trials

Autophagy and Pathological Aging

Start date: June 2017
Phase: N/A
Study type: Interventional

Autophagy is recognized as a central mechanism for the regulation of aging. . Osteoporosis (OA) and Alzheimer's disease (AD) are two forms of pathological aging, sometimes entangled, including an over-risk of OP in AD and degradation of cognitive functions after OP fracture, but the link between These two pathologies remain poorly understood. The aim of this prospective pilot study is to evaluate the level of autophagy of osteocytes (OST) in postmenopausal women with OP and to explore the hypothesis that the defect of autophagy is one of the physiopathological links of the OP During the MA

NCT ID: NCT03165747 Not yet recruiting - Clinical trials for Menopausal Osteoporosis

Effect of VSL#3 on Bone Mineral Density in Postmenopausal Women

Start date: October 2017
Phase: Phase 2
Study type: Interventional

Osteoporosis has a devastating impact on quality of life of postmenopausal women, and is a significant cause of disability and morbidity. Many drugs are approved for the prevention and treatment of osteoporosis, but are associated with high costs and side effects. Some data from animal studies suggests that supplementation with probiotics can safely treat and prevent osteoporosis. The probiotic VSL#3 is commercially available, is safe for human consumption, and has been widely used in human clinical trials, and has known health-promoting effects in both children and adults. The double-blind, randomized, placebo-controlled trial of VSL#3 will be conducted for 12 months in 40 postmenopausal women to determine if VSL#3 improves bone mineral density and related bone markers. Study visits will include all or some of the following procedures: a medical exam, urine collection, height and weight measurement, a blood draw to assess bone biomarkers, a DEXA (dual energy X-ray absorptiometry) scan to measure bone density, and health questionnaires. This is one of the first clinical trials proposed to investigate the effects of probiotics in bone in humans. If successful, this proposal will provide the first evidence that nutritional supplementation with the probiotic VSL#3 is a safe and effective strategy for preventing postmenopausal bone loss.

NCT ID: NCT03164928 Not yet recruiting - Clinical trials for Glucocorticoid-induced Osteoporosis

Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis

Start date: November 24, 2017
Phase: Phase 3
Study type: Interventional

To evaluate the effect of denosumab on lumbar spine bone mineral density (BMD) Z-score as assessed by dual-energy X-ray absorptiometry (DXA) at 12 months in children 5 to 17 year of age with Glucocorticoid (GC)-induced osteoporosis (GiOP).

NCT ID: NCT03158246 Not yet recruiting - Clinical trials for Osteoporosis, Postmenopausal

Generic Zoledronic Acid Versus Original Zoledronic Acid in Postmenopausal Osteoporotic Women

Start date: June 1, 2017
Phase: Phase 4
Study type: Interventional

This study compares the efficacy and safety of generic zoledronic acid (Yigu®) and original zoledronic acid (Aclasta®) in the treatment of postmenopausal osteoporotic women in China. Four hundred and sixty-six subjects will be randomised (1:1ratio) to either Yigu® 5mg IV or Aclasta® 5mg IV treatment arms.