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Optimized Cardioprotection Therapy in Obese Subjects With CAD

Obesity Clinical Trial

Official title:
Effects and Mechanism of Adipokines Cardiac Protection in Obese Patients With Coronary Artery Disease (CAD)

Clinical Trial Summary

The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With coronary artery disease (CAD).

Clinical Trial Description

Adipokines (or adipocytokines) can be defined as a group of more than 600 bioactive molecules made from adipose tissue that acts as paracrine and endocrine hormones. Adipokines are involved in maintaining varieties of processes such as, appetite and satiety, energy expenditure activity, endothelial function, blood pressure, hemostasis, adipogenesis, insulin sensitivity, energy metabolism in insulin-sensitive tissues, fat distribution and insulin secretion in pancreatic β-cells. Adipokines may contribute to reduce scar formation and improve cardiac function in coronary artery disease (CAD). Reperfusion therapy such as percutaneous coronary intervention (PCI) should be administered to all eligible patients with CAD symptom. However, our previous work showed that obese patients may benefit more from PCI. Thus, the aim of the present study was to investigate the efficacy and mechanism of adipokines cardiac protection for obese and non-obese patients with coronary artery disease (CAD). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04570527
Study type Observational
Source Xijing Hospital
Contact Dongdong Sun, MD, PhD
Phone 86 29 84775183
Email wintersun3@gmail.com
Status Recruiting
Phase
Start date January 1, 2019
Completion date December 30, 2022
View Details
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