Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Numbers of participants with pregnancy complications |
Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy |
At delivery |
|
Primary |
Numbers of participants with adverse pregnancy outcomes |
Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects. |
At delivery |
|
Secondary |
Weight in kilogram changes during childhood |
Measured by health professionals in clinic |
At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
|
Secondary |
Height in centimeter changes during childhood |
Measured by health professionals in clinic |
At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
|
Secondary |
Early Child development 1 |
Measured by Ages&Stages Questionnaires (ASQ).There are 6 questions in each of 5 domains of development: communication, gross motor, fine motor, problem-solving skills, and adaptive skills. Each question is given a 10 (yes), 5 (sometimes), or 0 (not yet) score according to the parents' answers. The sum scores (range from 0 to 300) and scores for each domain (range from 0 to 60) are calculated. Chinese norms are available for each domain, and any domain screened <2 SDs below the mean is considered a positive screening. A higher ASQ score means better development. |
Age at 6 weeks and 3 years |
|
Secondary |
Early Child development 2 |
Measured by Denver Developmental Screening Test (DDST). DDST comprises 125 test items grouped into four domains of child development: 25 personal-social (PS), 29 fine motor (FM), 39 language (LA) and 32 gross motor (GM). These test items are administered using a bell, glass bottle, set of 10 blocks, rattle, pencil, tennis ball, yarn, raisins, cup, white doll, white paper, and baby bottle. A child's raw score on each test item is marked as tested pass, failure, refusal, or no opportunity. The result of the test is labeled as "normal," "suspect" or "abnormal". Normal development means that there is no delay or at the maximum one warning. Abnormal development means that there is one or more than one delay situation. Suspicious development means that it is a situation involving one delay, one delay and one warning or two or more than two warnings. The number of children with normal, suspect or abnormal development is calculated. |
Age at 8-12 months |
|
Secondary |
Incidence of diabetes mellitus in women |
Measured by health professionals in clinic |
6 weeks after delivery and 3 years after delivery |
|
Secondary |
Incidence of hypertension in women |
Measured by health professionals in clinic |
6 weeks after delivery and 3 years after delivery |
|
Secondary |
Incidence of child overweight and obesity |
Measured by health professionals in clinic |
Age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
|
Secondary |
The proportion of children with warning signs |
Measured by warning signs screening |
Age at 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
|
Secondary |
Fetal Biparietal Diameter |
Measured by health professionals in clinic with ultrasound |
At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
|
Secondary |
Fetal Head Circumference |
Measured by health professionals in clinic with ultrasound |
At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
|
Secondary |
Fetal Abdominal Circumference |
Measured by health professionals in clinic with ultrasound |
At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
|
Secondary |
Fetal Femur Length |
Measured by health professionals in clinic with ultrasound |
At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
|
Secondary |
Fetal Humerus Length |
Measured by health professionals in clinic with ultrasound |
At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
|