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Anemia clinical trials

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NCT ID: NCT03633656 Not yet recruiting - Clinical trials for Renal Insufficiency, Chronic

Iron Dosing Pilot Study Using Model Predictive Control

Start date: October 2018
Phase: N/A
Study type: Interventional

This is a pilot study to test the utility of an integrated approach in the management of the anemia of chronic kidney disease through the administration of both an erythropoietic stimulating agent and iron. Subjects will be studied for 6 months during which all iron dosing will be recommended using a computer based tool using model predictive control. Comparisons will be made to the 6 months prior to enrollment in to the study.

NCT ID: NCT03633604 Available - Anemia Severe Clinical Trials

Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia

Start date: n/a
Phase:
Study type: Expanded Access

HBOC-201 provides an oxygen treatment bridge and can be used to eliminate, delay, or reduce the need for red blood cell transfusions in anemic patients This is an expanded access IND protocol, and will provide treatment with HBOC-201 to severely anemic adults for whom blood is not an option

NCT ID: NCT03625661 Completed - Clinical trials for Iron Deficiency Anemia

Impact and Evaluation of the Management of Iron Deficiency With or Without Anemia in Patients With Cancer

CAMARA
Start date: February 2, 2014
Phase: N/A
Study type: Interventional

In oncology, anemia is a frequent symptom, leading to complication of patient management for, more or less, a long term but often poorly evaluated by medical teams. In oncology, anemia is induced by multiple causes. Iron deficiency appears to be a leading cause of anemia, especially in people with solid cancer. Iron deficiency is characterized by a low level of iron . Iron is a trace element required for life. It is a major component of hemoglobin allowing the transport of oxygen in red blood cells. There are in fact 2 types of iron deficiency: an absolute iron deficiency with a deficiency of true iron and a functional iron deficiency. Since end of January 2014, intravenous iron-based injections have been reclassified for cancer patients at ICO Paul Papin. The monitoring of iron deficiency with or without anemia is currently done in our institute, the ICO-Paul Papin. There is a procedure for the management of anemia with or without iron deficiency but there is still no traceability of treatments performed, their compliance or even their impact on the rate hemoglobin and the quality of life of patients during their treatment. This observatory also makes it possible to evaluate the impact of this treatment on the quality of life of the patients and thus allows them a personalized care of the tiredness during their treatment

NCT ID: NCT03623997 Completed - Clinical trials for Iron Deficiency Anemia

Oral Iron Supplementation in Iron Deficiency Anemia

Start date: October 10, 2017
Phase: N/A
Study type: Interventional

Iron deficiency (ID) with or without anaemia (IDA) is a major public health problem worldwide, in particular in women of reproductive age. Iron supplementation can be an effective strategy to prevent and treat ID and IDA. Anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice and compliance is low due to mild gastrointestinal side effects. The investigators will compare iron absorption from single oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.

NCT ID: NCT03619850 Recruiting - Clinical trials for Chronic Kidney Disease; Iron Deficiency Anemia

A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)

Start date: August 13, 2018
Phase: Phase 3
Study type: Interventional

Primary Objectives: To evaluate the safety (compared to iron sucrose) and efficacy of ferumoxytol in pediatric CKD subjects with iron deficiency anemia (IDA) or who are at risk of development of IDA Secondary Objective: To determine the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) profile of ferumoxytol in pediatric subjects.

NCT ID: NCT03618914 Completed - Inflammation Clinical Trials

Anemia and Inflammation

Start date: September 15, 2017
Phase: N/A
Study type: Interventional

Wheat-flour fortification programs in Morocco have not been successful so far. A potential reason for that might be the consumption of tea with the meals. Whether NaFeEDTA can overcome the inhibitory effects of the polyphenols present in a typical Moroccan tea is uncertain. During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain.

NCT ID: NCT03600909 Recruiting - Clinical trials for Myelodysplastic Syndrome (MDS)

A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia

Start date: May 15, 2018
Phase: Phase 2
Study type: Interventional

The goal of this study is to see if the study therapy can decrease the chemotherapy-related side effects while maximizing the effectiveness of disease control. The physicians will also be studying the effect of removing T-cells from the donor‟s stem cells before transplant. T-cells are a type of white blood cell that may help cause a serious side effect of transplant called Graft versus Host Disease (GVHD). The way it removes the T-cells from the donor stem cells is actually by selecting only the stem cells (called CD34 cells) by using a device called CliniMACS. This process is called CD34 selection. The CliniMACS® device is currently under the supervision of the FDA .

NCT ID: NCT03596996 Recruiting - Hiv Clinical Trials

Optimizing Iron Status While Minimizing Morbidity in HIV-infected Ugandan Children

Start date: April 19, 2018
Phase: N/A
Study type: Interventional

Randomized, placebo-controlled trial of the effect of 84 days of daily iron supplementation on iron status, gut microbiome profile, infectious disease frequency, and HIV disease severity in moderately anemic [hemoglobin 9 - <11 g/dL (6-59 mo); hemoglobin 9 - < 11.5 g/dL (5 -12 years)], HIV-infected Ugandan children between the ages of 6 mos and 12 years.

NCT ID: NCT03591406 Recruiting - Clinical trials for Iron Deficiency Anemia

To Assess the Impact of Ferric Carboxymaltose Compared With Iron Sucrose in Chinese Subjects on Correcting Iron Deficiency Anaemia

Start date: July 3, 2017
Phase: Phase 3
Study type: Interventional

The primary objective is to demonstrate the efficacy of ferric carboxymaltose (FCM) given in a simple dosing regimen in correcting iron deficiency anaemia (IDA), by demonstrating non-inferiority to treatment with the currently approved intravenous (IV) iron therapy of iron sucrose (IS, Venofer) in the Chinese population. The secondary objectives are to assess the safety of FCM compared to IS in the Chinese population and to evaluate the effect of FCM compared to IS on relevant laboratory parameters (haematology, chemistry, iron parameters) in the Chinese population.

NCT ID: NCT03586141 Recruiting - Anemia Clinical Trials

Pronto for Patient Blood Management

Start date: July 22, 2018
Phase: N/A
Study type: Interventional

The concept of Patient Blood Management requires preoperative diagnostic of anemia. To avoid the harmful procedure of venous puncture for drawing a blood sample, noninvasive measurement of hemoglobin has been developed. However noninvasive measurement of hemoglobin has yet been not accurate enough to replace invasive hemoglobin measurement. This study investigates if a noninvasive measurement tool can serve as a screening tool to find out for which patients invasive measurement of hemoglobin is necessary.