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Preterm Birth clinical trials

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NCT ID: NCT03401255 Not yet recruiting - Preterm Birth Clinical Trials

Interest of a Vaginal Swab in Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth

Start date: January 15, 2018
Phase: N/A
Study type: Observational

Preterm labor is the first cause of hospitalization during the pregnancy, and at the origin of more than 60 000 births before 37 weeks of amenorrhea every year in France. It is however difficult to predict if a patient consulting in emergencies with symptoms of preterm labor, will give birth prematurely or not. Current diagnostic tools to identify patients with high risk of premature delivery in 7 days are insufficient because of their low positive predictive value. Yet the neonatal complications in case of premature delivery are important, with respiratory distress syndrome, hyaline membrane disease, necrotizing enterocolitis, intraventricular hemorrhage and post-natal death. Recent studies suggested that the detection of the placental alpha microglobulin 1 (PAMG-1) in the vaginal secretions, by Partosure® test at the women presenting symptoms of preterm labor with intact membranes would indicate that a premature spontaneous delivery could arise in 7 days with a good positive predictive value.The test is interesting all the more as the repetition of the prenatal cures of corticosteroids, aiming at the fetal lung maturation, is this day more recommended and as the beneficial effect takes place within 24 hours in 7 days following their administration. It seems thus essential to make studies to specify the interest of this test at the patients presenting a preterm labor. This study aims at estimating the diagnostic performance of the test of detection of PAMG-1 in the prediction of a delivery in 7 days, at the patients presenting symptoms of preterm labor.

NCT ID: NCT03394443 Recruiting - Preterm Birth Clinical Trials

Which Needs for Premature New-born Babies' Parents Facing Environmental and Social Difficulties ?

Start date: December 28, 2017
Phase: N/A
Study type: Observational

This study aims to understand parents' needs regarding social difficulties faced in a child's preterm birth context.

NCT ID: NCT03393637 Active, not recruiting - Preterm Birth Clinical Trials

Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

The M-O-M-S project evaluates the effectiveness of the M-O-M-S program for improving birth outcomes and maternal-infant attachment and role satisfaction in a large military sample.

NCT ID: NCT03360539 Recruiting - Preterm Birth Clinical Trials

Nurse-Family Partnership Impact Evaluation in South Carolina

Start date: April 1, 2016
Phase: N/A
Study type: Interventional

This study evaluates the effects of the Nurse Family Partnership (NFP), an established home-visiting program, using a scientifically rigorous individual-level randomized controlled trial. The study will be based in South Carolina, where a Medicaid waiver in combination with a pay-for-success contract will allow expansion of the program to women on Medicaid. The study plans to enroll 4000 low-income, first time mothers and their children into the intervention group, and another 2000 into the control group. The study will evaluate the program's impacts on outcomes using administrative records. This study aims to yield new evidence on the effect of NFP in a modern context, applied to a new population, across a broad range of outcomes, and financed by a novel public-private partnership based on accountability for outcomes.

NCT ID: NCT03357458 Not yet recruiting - Preterm Birth Clinical Trials

Parent-child Interactions, Child Developmental Health, and Health System Costs at 6 Months Corrected Age

Start date: January 22, 2018
Phase: N/A
Study type: Interventional

The aim of this novel health services research proposal is to assess the longer-term outcomes, to 6 months corrected age, of an adapted Family Integrated Care (FICare) model of care for moderate and late preterm infants admitted to a Level II neonatal intensive care unit (NICU). This follow-up study will enroll infants at 6 months CA (± 1 month) recruited to the original FICare randomized controlled trial ( ID: NCT02879799) from four level II NICU sites; two intervention and two control.

NCT ID: NCT03340688 Recruiting - Preterm Birth Clinical Trials

Cerclage for Twins With Short Cervical Length ≤ 15mm

Start date: June 22, 2017
Phase: N/A
Study type: Interventional

This is a multicenter randomized study designed to determine if ultrasound indicated cerclage reduces the incidence of spontaneous preterm birth <34 weeks in asymptomatic women with twin gestations and cervical length ≤15mm, diagnosed by transvaginal ultrasound between 16 to 23 6/7 weeks of gestation.

NCT ID: NCT03304782 Not yet recruiting - Preterm Birth Clinical Trials

Fitbit Activity Tracker to Predict Risk of Preterm Birth

Start date: October 30, 2017
Phase: N/A
Study type: Interventional

Almost half of all deliveries in the United States are of nulliparous patients. They have been identified as an at-risk population for preterm birth. Historically, the most significant risk factor for preterm birth is a prior history of preterm birth, which cannot be applied to a nulliparous population. Forecasting adverse outcomes in first time moms is difficult to predict and prevent. Historically, physicians have prescribed a restriction in activity level for those at risk for preterm delivery. The utility of this intervention has yet to be prospectively and quantitatively studied. The Fitbit activity tracker is a wearable device that has been extensively used in medical research, in an attempt to quantitatively identify how patient activity levels can improve medical outcomes. The study uses the Fitbit device in nulliparous patients, remotely track their activity levels throughout pregnancy, and assess pregnancy outcomes. Because of the significant and long-standing health disparity in the incidence of preterm delivery, the investigators will use the "Everyday Discrimination Scale", a validated battery of racism and health to see how a patient's stress related to perceived discrimination may modify the risk of preterm delivery.

NCT ID: NCT03292731 Not yet recruiting - Preterm Birth Clinical Trials

Relationship Between Plasma Concentration of Hydroxyprogesterone Caproate (17-OHPC) and Preterm Birth

Start date: January 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The study plans to determine the relationship between plasma concentrations of 17-OHPC (hydroxyprogesterone caproate) and the rate of preterm birth. The study is a randomized, open label study of pregnant women with one or more prior spontaneous preterm births. Subjects are randomized to a weekly single injection of either 250 or 500mg 17-OHPC (hydroxyprogesterone caproate).

NCT ID: NCT03274960 Active, not recruiting - Preterm Birth Clinical Trials

Screening and Treating Asymptomatic Bacteriuria Every Trimester and Preterm Birth

Start date: February 23, 2017
Phase: N/A
Study type: Interventional

This study is evaluating whether screening of a pregnant woman for asymptomatic bacteriuria in each trimester for early detection and treatment of bacteriuria will reduce the incidence of preterm birth in Harare.

NCT ID: NCT03271723 Completed - Physical Activity Clinical Trials

The 2015 Pelotas (Brazil) Birth Cohort Study

Start date: April 15, 2014
Phase: N/A
Study type: Observational

This is the fourth birth cohort to be carried out in the city of Pelotas (Brazil) including more than 4 thousand children followed-up since the pre-natal period to study maternal-child health.