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NCT ID: NCT00000106 Active, not recruiting - Rheumatic Diseases Clinical Trials

41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases

Start date: n/a
Phase: N/A
Study type: Interventional

Recently a non-toxic system for whole body hyperthermia (WBH) used at the University of Wisconsin has been shown to induce soluble tumor necrosis factor-receptor (sTNF-R) I and II when patients are heated systemically to 41.8C for 60 minutes. This observation might provide a biological basis for the therapeutic application of WBH to rheumatoid diseases, for which there is a positive anecdotal clinical experience. Inherent in the hypothesis which is the basis for this protocol is the concept that the induction of TNF receptors by WBH may induce a remission in patients with active rheumatoid arthritis. Beyond clinical response the biological endpoint for this investigation includes cytokine levels, TNF levels, sTNF-R levels and changes in cellular TNF receptors.

NCT ID: NCT00000111 Active, not recruiting - Mouth Diseases Clinical Trials

Intraoral Grafting of Ex Vivo Produced Oral Mucosal Composites

Start date: n/a
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see if we can develop a good graft for oral mucosal tissue that is like the top of the mouth in a "test tube" that could be used successfully in humans. We have already done this successfully mice. The next step is to take a small piece of tissue from a human volunteer and see if we can grow a larger piece of tissue from it outside the human body and graft it back into the same person successfully. We expect that this technique will work. It has already been tried in patients with burns of the skin who have had similar procedures where the skin is grafted back to them. The significance of this research is that oral tissue taken from the top of the mouth or palate is in limited supply and leaves the patient with a painful and uncomfortable post surgery experience. If we are successful with our technique the patient will experience less pain and discomfort from the site that we are using to grow our tissue outside the body than if we had taken it from the top of the mouth or palate. In addition, by waiting longer periods to grow the patient's cells we can make larger pieces of oral tissue than we could have gotten directly from the patient's mouth. Patients who will participate in this study will need to require a soft tissue graft from the mouth to an area that needs additional attached or keratinized mucosa. This will most likely be either in preparation for patients who have or will have dental implants placed. Another subset of patients are those who need scar tissue released or the vestibule of their mouth (area that turns from the gums to the lip) released.

NCT ID: NCT00000346 Active, not recruiting - Clinical trials for Amphetamine-Related Disorders

Cognitive Correlates of Substance Abuse - 11

Start date: n/a
Phase: Phase 4
Study type: Interventional

The purpose of this study is to characterize the cognitive performance of methamphetamine abusers by comparing them with cocaine abusers and normal controls.

NCT ID: NCT00000348 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13

Start date: n/a
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate safety issues pertaining to dihydrexidine (DHX), to cocaine, and to its interaction, and to determine how pretreatment with DHX modifies the subjective as well as physiological effects of cocaine infusion.

NCT ID: NCT00000349 Active, not recruiting - Clinical trials for Cocaine-Related Disorders

Infusion Laboratory: Protocol 5 (Flupenthixol) - 14

Start date: n/a
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as physiological effects of cocaine. Taken together, these relatively D-1 selective agents can help determine the extent to which DA-1 binding affects the reinforcing effects of stimulants.

NCT ID: NCT00000351 Active, not recruiting - Clinical trials for Amphetamine-Related Disorders

Cognitive Correlates of Substance Abuse, Part 2 - 16

Start date: n/a
Phase: Phase 4
Study type: Observational

Part II: Examine cognitive performance of stimulant abusers (methamphetamine and cocaine) during recovery by assessing their cognitive function at monthly intervals.

NCT ID: NCT00002099 Active, not recruiting - HIV Infections Clinical Trials

Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients

Start date: n/a
Phase: Phase 2
Study type: Interventional

To determine the tolerance and side effects of a combination of lentinan and didanosine (ddI) in comparison with ddI alone. To determine whether the combination of lentinan and ddI produces a significant immunorestorative effect within the study observation period (6-12 months) as measured by an increase in one or more of the following: neutrophil count and activity, T-cell subsets, and a decrease in p24 antigen.

NCT ID: NCT00002158 Active, not recruiting - HIV Infections Clinical Trials

A Study to Evaluate the Use of Nitazoxanide to Treat Cryptosporidiosis

Start date: n/a
Phase: N/A
Study type: Interventional

The purpose of this study is to see if nitazoxanide (NTZ) can be used to treat AIDS patients suffering from cryptosporidiosis (diarrhea caused by the parasite Cryptosporidium).

NCT ID: NCT00002219 Active, not recruiting - HIV Infections Clinical Trials

Safety and Effectiveness of Adding Adefovir Dipivoxil and Nelfinavir to the Anti-HIV Therapy of HIV-Infected Children

Start date: n/a
Phase: Phase 2
Study type: Interventional

The purpose of this study is to see if it is safe and effective to give adefovir (a new anti-HIV drug) plus nelfinavir to HIV-infected children who are already receiving other anti-HIV medications.

NCT ID: NCT00002241 Active, not recruiting - HIV Infections Clinical Trials

Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily

Start date: n/a
Phase: Phase 2
Study type: Interventional

The purpose of this study is to see whether taking indinavir (IDV) plus ritonavir (RTV) plus stavudine (d4T) plus lamivudine (3TC) 2 times each day is safe and can lower the level of HIV in the blood.