Hypertension Clinical Trial
Official title:
Prospective Characterization of the Heart, Aorta and Blood Pressure in Women With Turner Syndrome. Association With Aortic Dissection.
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes
affecting 1 of 2000 live born girls. The syndrome is characterized by an increased
prevalence of ischemic heart disease, aortic dilation and dissection, hypertension, stroke
and autoimmune diseases in general.
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to
characterize the prevalence and degree of ischemic heart disease and coronary
anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of
aortic stiffness when compared to controls using end points as Pulse Wave Velocity,
Augmentation Index and Central Pulse Pressure.
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes
affecting 1 of 2000 live born girls. The syndrome is characterized by an increased
prevalence of ischemic heart disease, aortic dilation and dissection, congenital heart
defects, hypertension, stroke, ovarian failure, infertility, decreased final height and
autoimmune diseases in general
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to describe aortic dimensions
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to
characterize the prevalence and degree of ischemic heart disease and coronary
anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of
aortic stiffness when compared to controls using end points as Pulse Wave Velocity,
Augmentation Index and Central Pulse Pressure.
;
Observational Model: Cohort, Time Perspective: Prospective
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