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NCT00005489 Clinical Trial

Salt Sensitivity, Cardiovascular and Metabolic Disease

Hypertension Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00005489
Other study ID # 5005
Secondary ID R01HL057826
Status Completed
Phase N/A
First received May 25, 2000
Last updated December 28, 2015
Start date January 1998
Est. completion date December 2001

Study information
Verified date December 2015
Source Indiana University
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Description:

DESIGN NARRATIVE:

Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date December 2001
Est. primary completion date
Accepts healthy volunteers No
Gender Male
Age group N/A to 100 Years
Eligibility No eligibility criteria

Study Design

N/A

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Indiana University National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (5)

Weinberger M, Weinberger MH, Fineberg N, Fineberg SE, Wagner U. Long-term follow-up of participants in clinical studies. J Clin Epidemiol. 2002 Mar;55(3):230-4. — View Citation

Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension. 2001 Feb;37(2 Pt 2):429-32. — View Citation

Weinberger MH, Fineberg NS, Fineberg SE. Effects of age, race, gender, blood pressure, and estrogen on arterial compliance. Am J Hypertens. 2002 Apr;15(4 Pt 1):358-63. — View Citation

Weinberger MH, Fineberg NS, Fineberg SE. The influence of blood pressure and carbohydrate tolerance on vascular compliance in humans. Am J Hypertens. 2002 Aug;15(8):678-82. — View Citation

Weinberger MH. Salt sensitivity is associated with an increased mortality in both normal and hypertensive humans. J Clin Hypertens (Greenwich). 2002 Jul-Aug;4(4):274-6. — View Citation

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