Hypertension Clinical Trial
To ascertain the sixteen year mortality status of the 361,662 middle-aged men screened in 1973-1975 for the Multiple Risk Factor Intervention Trial (MRFIT).
BACKGROUND:
The Multiple Risk Factor Intervention Trial was a randomized primary prevention trial to
test the effect of a multifactor intervention program on mortality from coronary heart
disease in 12,866 high-risk men aged 35 to 57. The primary screening for MRFIT began in
November 1973 and continued through November 1, 1975. The primary screening was conducted at
clinical center sites, central neighborhood locations, and places of employment. Information
was collected on smoking history, blood pressure, serum cholesterol, birthdate, race, and
social security number as well as previous hospitalization for a heart attack and use of
medication for diabetes. Systolic and diastolic blood pressures were measured and blood
drawn for serum cholesterol determinations. The results of the screening examination were
transmitted to the Coordinating Center.
DESIGN NARRATIVE:
Using data supplied by the Social Security Administration, the vital status of the MRFIT
screenees was determined. A screenee was identified as deceased if the social security
number and first two letters of the last name, as recorded on the MRFIT screening form,
matched a record on the Social Security Administration master death file. The state health
department was contacted to obtain the death certificate which was then coded for the
underlying cause of death according to the International Classification of Diseases, 9th
Revision. Because the Social Security Adminstration master death file was not completely
accurate, the National Death Index was also used. Studies were conducted on the
relationships of isolated systolic hypertension to stroke and coronary heart disease
mortality, and on seasonal and regional variations in cardiovascular mortality. Using data
from the Census Bureau (education and income levels by zip code), the socio-economic status
of participants was indirectly estimated and the coronary heart disease and cancer death
rate differences between white and Black men were evaluated by social class. Studies were
also conducted on the associations of cause- specific cancer mortality and serum cholesterol
concentration, and on the association of serum cholesterol, diastolic blood pressure, and
cigarettes smoked per day with mortality from coronary heart disease and cerebrovascular
disease for Black and white men.
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