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Cardiomyopathies clinical trials

View clinical trials related to Cardiomyopathies.

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NCT ID: NCT03801681 Recruiting - Heart Failure Clinical Trials

ARrhythmias in MYocarditis

Start date: November 1, 2018
Study type: Observational [Patient Registry]

Myocarditis promotes the occurrence of serious cardiac arrhythmias and conduction disorders which may lead to sudden cardiac death, the need for catheter ablation of arrhythmia or implantation of a cardioverter-defibrillator or pacemaker. The aim of the study is to fill the evidence gap regarding the type and burden of arrhythmias in patients with myocarditis and their correlation with clinical parameters, biomarkers and additional tests. During a multi-center observational study, patients will be subjected to prolonged ECG monitoring. As a result, a risk scale will be created that can facilitate the identification of patients with an increased risk of arrhythmia and further specifying recommendations for therapeutic management.

NCT ID: NCT03798652 Recruiting - Clinical trials for Cardiovascular Diseases

Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study

Start date: January 26, 2019
Study type: Observational

The study will investigate whether a new high resolution heart Magnetic Resonance Imaging scan, combining assessment of ischemia and viability by perfusion and Late Gadolinium Enhancement -Cardiac Magnetic Resonance is superior to Late Gadolinium Enhacement imaging alone in predicting functional recovery following revascularisation.

NCT ID: NCT03797092 Not yet recruiting - Clinical trials for Non-ischemic Dilated Cardiomyopathy

Stem Cell Therapy in Non-IschEmic Non-treatable Dilated CardiomyopathiEs II: a Pilot Study

Start date: January 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The overall aim of the project is to test the feasibility and safety of allogeneic adipose-derived stromal cells (CSCC_ASC) investigational medicinal product, to improve myocardial function in patients with non-ischemic dilated cardiomyopathies (NIDCM) and heart failure.

NCT ID: NCT03787810 Recruiting - Clinical trials for Acute Coronary Syndrome

Left Ventricular Dysfunction in Critically Ill Patients

Start date: August 20, 2018
Study type: Observational

Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.

NCT ID: NCT03780231 Recruiting - Clinical trials for Athletes With Isolated Non-ischemic LGE With no Underlying Labelled Cardiomyopathy

Effect of Intense Sport Practice in Athletes With Non-ischemic Scar

Start date: October 5, 2018
Study type: Observational

The prognostic relevance of isolated non-ischemic LGE (i.e. with no underlying "labelled" cardiomyopathy) is unclear, and current guidelines to not state on the clearance of athlete with this type of findings as regards to competitive or intense sport practice. The principal objective of the study is to evaluate during a five-years follow up, the clinical outcome of athletes with this kind of findings. The secondary objective is the determination of prognostic factors. The management and follow-up of the athletes will be let at the appraisal of each center.

NCT ID: NCT03779646 Not yet recruiting - Clinical trials for Duchenne Muscular Dystrophy

Bisoprolol in DMD Early Cardiomyopathy

Start date: January 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This study aimed to use cardiac magnetic resonance imaging (CMR) to evaluate the efficacy and safety of bisoprolol therapy for boys with Duchenne muscular dystrophy(DMD) and preserved ejection fraction. On top of angiotensin-converting enzyme inhibitor (ACEI) , half of the participants will receive bisoprolol in combination, while the other half will not receive any beta-blocker.

NCT ID: NCT03775070 Not yet recruiting - Clinical trials for Dilated Cardiomyopathy

Simvastatin Therapy in Patients With Dilated Cardiomyopathy.

Start date: December 31, 2018
Phase: Phase 2
Study type: Interventional

Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. About half of patients die or require heart transplantation within 5 years of diagnosis. The medical therapy for DCM with heart failure includes anti-congestive medications and antiplatelet therapy. Those who fail to improve within the first year of diagnosis usually deteriorated even upon aggressive anti-congestive medications. The investigators had conducted precision-medicine-based approach to provide strategic approach as drug repurposing to identify new treatments. The investigators have identified the beneficial effects from a statin, simvastatin, to restore the cardiac contractility. The investigators would further assess the efficacy of simvastatin to improve the cardiac function in patients with DCM.

NCT ID: NCT03767855 Recruiting - Clinical trials for Symptomatic Obstructive Hypertrophic Cardiomyopathy

A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

Start date: December 2018
Phase: Phase 1
Study type: Interventional

The purposes of this study are to: 1. Learn about the safety of CK-3773274 after a single dose and multiple doses in healthy subjects. 2. Learn how healthy subjects tolerate CK-3773274 after a single dose and multiple doses. 3. Find out how much CK-3773274 is in the blood after a single dose and multiple doses. 4. Determine the effect of CK-3773274 on the pumping function of the heart

NCT ID: NCT03761654 Recruiting - Clinical trials for Left Ventricular Dysfunction

Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN)

Start date: January 2, 2019
Study type: Observational

Subarachnoid hemorrhage (SAH) can cause transient myocardial dysfunction. Recently, it have been reported that myocardial dysfunctions that occur in SAH are associated with poor outcomes. It therefore appears essential to detect theses dysfunctions with the higher sensitivity as possible. Strain measurement using speckle-tracking echocardiography may detect myocardial dysfunction with great sensitivity. The main objective of this study is to assess the prevalence of myocardial dysfunction in "non-severe" SAH (defined by a WFNS grade 1 or 2), using speckle-tracking echocardiography. This study also aims to analyse Strain measurement with classical echocardiography and serum markers (troponin, BNP) of cardiac dysfunction.

NCT ID: NCT03754101 Recruiting - Clinical trials for Dilated Cardiomyopathy

Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

Start date: March 3, 2003
Study type: Observational

Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.