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HIV Infections clinical trials

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NCT ID: NCT00004584 Completed - HIV Infections Clinical Trials

Safety and Effectiveness of a New Protease Inhibitor, BMS-232632, in HIV-Positive Patients Who Have Received Previous Treatment

Start date: December 1999
Phase: Phase 2
Study type: Interventional

The purpose of this study is to look at the safety and effectiveness of an experimental protease inhibitor (a type of anti-HIV drug) called BMS-232632. Doctors will compare an anti-HIV drug combination that includes BMS-232632 to a drug combination that includes ritonavir.

NCT ID: NCT00004583 Completed - HIV Infections Clinical Trials

A Phase III Study Comparing Two Different Anti-HIV Drug Combinations in HIV-Positive Patients Without Previous Anti-HIV Drug Therapy

Start date: March 1999
Phase: Phase 3
Study type: Interventional

The purpose of this study is to see how safe a new protease inhibitor (PI) is and how well it fights HIV infection. A PI is a drug that stops HIV from using healthy cells to make more virus. This study will compare the new PI combination of ABT-378 plus ritonavir (RTV) with another PI, nelfinavir (NFV). Earlier studies suggest ABT-378/RTV will be just as good as and perhaps better than NFV at fighting HIV infection.

NCT ID: NCT00004582 Completed - HIV Infections Clinical Trials

ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

Start date: n/a
Phase: Phase 2
Study type: Interventional

The purpose of this study is to see if ABT-378/ritonavir plus efavirenz is safe and effective in lowering the amount of HIV in the blood of patients who have been treated with more than 1 protease inhibitor (PI).

NCT ID: NCT00004581 Completed - HIV Infections Clinical Trials

A Study to Compare Two Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Previously Received Anti-HIV Treatment

Start date: n/a
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the safety and effectiveness of 2 anti-HIV drug combinations in HIV-infected patients. Both combinations will include nevirapine (NVP), 2 nucleoside reverse transcriptase inhibitors (NRTIs), and at least 1 protease inhibitor (PI). One combination will include a new protease inhibitor, ABT-378, combined in a capsule with ritonavir (RTV).

NCT ID: NCT00004580 Completed - HIV Infections Clinical Trials

A Study of ABT-378/Ritonavir Combination in HIV-Infected Patients Who Have Taken Protease Inhibitors

Start date: n/a
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see if it is safe and effective to give ABT-378/ritonavir combination plus nevirapine plus two nucleoside transcriptase inhibitors to HIV-infected patients who previously have taken protease inhibitors. This study also examines how the body handles this combination of anti-HIV drugs.

NCT ID: NCT00004579 Completed - HIV Infections Clinical Trials

A Study to See Whether Two HIV Vaccines Are Safe and Can Prevent HIV Infection

Start date: April 1998
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see whether an HIV vaccine, ALVAC vCP205, is safe and can prevent HIV infection. The vCP205 vaccine will be tested with another vaccine, gp160MN/LAI-2.

NCT ID: NCT00004578 Completed - HIV Infections Clinical Trials

ABT-378/Ritonavir in Combination With Reverse Transcriptase Inhibitors in Antiretroviral Naïve HIV-Infected Subjects

Start date: November 1997
Phase: Phase 1/Phase 2
Study type: Interventional

To assess the safety, tolerability and antiviral activity of lopinavir/ritonavir when administered orally in antiretroviral-HIV-1 infected subjects.

NCT ID: NCT00004400 Completed - HIV Infections Clinical Trials

Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women

Start date: April 1997
Phase: Phase 2
Study type: Interventional

OBJECTIVES: I. Determine whether physiologic testosterone replacement can increase fat-free mass, therefore contributing to weight maintenance, improved muscle function, and quality of life in HIV-infected women. II. Examine the mechanism of testosterone-induced increase in fat-free mass.

NCT ID: NCT00004276 Completed - HIV Infections Clinical Trials

Phase II Placebo Controlled Study of Thalidomide in Patients With Mycobacterial and HIV Infections

Start date: September 1990
Phase: Phase 2
Study type: Interventional

OBJECTIVES: I. Evaluate whether thalidomide modulates toxic host inflammatory responses in patients receiving antitubercular therapy. II. Evaluate whether thalidomide modifies tumor necrosis factor-mediated toxic symptoms of HIV and mycobacterial infections, and limits progression of HIV immunodeficiency. III. Evaluate whether thalidomide stimulates immunity in patients with HIV and/or mycobacterial infections.

NCT ID: NCT00003262 Active, not recruiting - Lymphoma Clinical Trials

Combination Chemotherapy in Treating Patients With Hodgkin's Disease and HIV Infection

Start date: May 1997
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of two combination chemotherapy regimens in treating patients with Hodgkin's disease and HIV infection.