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HIV Infections clinical trials

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NCT ID: NCT00361257 Terminated - HIV Infections Clinical Trials

Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults

Start date: March 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the effectiveness of minocycline, an antibiotic, in lessening the decreased mental function sometimes caused by anti-HIV drugs.

NCT ID: NCT00361101 Completed - HIV Infections Clinical Trials

A Study of AMD11070 in HIV-infected Patients Carrying X4-tropic Virus

Start date: October 2005
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and activity of AMD11070 in HIV-infected patients carrying X4-tropic virus.

NCT ID: NCT00358917 Completed - Clinical trials for Human Immunodeficiency Virus Infections

Study of Lopinavir/Ritonavir Tablets Comparing Once-Daily Versus Twice-Daily Administration When Coadministered With Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Antiretroviral-Experienced Human Immunodeficiency Virus Type 1 Infected Subjects

Start date: August 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study was to compare the safety, tolerability, and antiviral activity of once-daily (QD) and twice-daily (BID) dosing of the lopinavir/ritonavir (LPV/r) tablet formulation in combination with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in antiretroviral-experienced human immunodeficiency virus type 1 infected subjects with detectable viral load while receiving their current antiretroviral therapy.

NCT ID: NCT00358696 Completed - HIV Infections Clinical Trials

Antiretroviral Switch From Didanosine to Tenofovir in HIV/HCV Co-infected Patients

Start date: July 2006
Phase: Phase 4
Study type: Interventional

The primary purpose of this study is to evaluate the impact of changing didanosine in an effective anti-HIV regimen to tenofovir on virologic suppression. We hypothesize that, in patients with maximal virologic suppression on a double class regimen (including two NRTIs and an NNRTI or a PI, boosted with RTV or not), a single drug substitution of didanosine for tenofovir will represent a viable strategy without any negative impact on the virologic efficacy of the regimen.

NCT ID: NCT00357721 Completed - HIV Infections Clinical Trials

Atazanavir Twice Daily

Start date: June 2006
Phase: Phase 1
Study type: Interventional

The purpose of this clinical research study is to assess the pharmacokinetics of atazanavir administered twice-daily relative to historical data from atazanavir/ritonavir 300/100 mg, given once daily.

NCT ID: NCT00357604 Completed - HIV Infections Clinical Trials

Atazanavir and Ritonavir (ATV/RTV) and an Oral Contraceptive in Healthy Females

Start date: July 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to administer a combined oral contraceptive (ethinyl estradiol and norgestimate) with the HIV treatment of atazanavir and ritonavir to healthy females in order to assess if the concentrations of the oral contraceptive change. The safety of this treatment regimen will also be studied.

NCT ID: NCT00357552 Completed - HIV Infections Clinical Trials

Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy

Start date: January 2008
Phase: N/A
Study type: Interventional

Most anti-HIV regimens include a non-nucleoside reverse transcriptase inhibitor (NNRTI); however, some individuals fail on these regimens. The purpose of this study is to evaluate the safety and effectiveness of the protease inhibitor (PI) lopinavir/ritonavir (LPV/r) in HIV infected individuals who are failing an anti-HIV regimen that includes an NNRTI.

NCT ID: NCT00357240 Completed - HIV Infections Clinical Trials

Drug Interaction Study With Proton Pump Inhibitor

Start date: June 2006
Phase: Phase 1
Study type: Interventional

The purpose of this clinical research study is to assess the effect of omeprazole at 20 mg on the pharmacokinetics of atazanavir administered as atazanavir with ritonavir relative to atazanavir or atazanavir/ritonavir in the absence of omeprazole in healthy subjects.

NCT ID: NCT00357188 Completed - HIV Infections Clinical Trials

Dose Finding Confirmation of Atazanavir With Ritonavir and Efavirenz (ATV/RTV + EFV) in Healthy Subjects

Start date: July 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the exposure of Atazanavir 400 mg with Ritonavir 100 mg and with Efavirenz 600 mg compared to Atazanavir 300 mg with 100 mg without Efavirenz in Healthy Subjects

NCT ID: NCT00356824 Completed - HIV Infections Clinical Trials

Relationship Between HIV and Malaria in Ugandan Children

Start date: November 2005
Phase:
Study type: Observational

HIV and malaria are two of the most important diseases to afflict children in sub-Saharan Africa. However, it is unknown what relationships exist between the two diseases. The purpose of this study is to determine the relationship between HIV and malaria infections in HIV infected Ugandan children.