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Heart Diseases clinical trials

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NCT ID: NCT03208244 Terminated - Hepatitis C Clinical Trials

DAA Treatment in Donor HCV-positive to Recipient HCV-negative Heart Transplant

Start date: November 9, 2017
Phase: Phase 4
Study type: Interventional

This is a proof of concept, single center study for the donation of HCV-positive hearts to HCV negative recipient patients, with preemptive, interventional treatment with 12 weeks of commercially available DAA therapy to prevent HCV transmission upon transplantation.

NCT ID: NCT03192215 Terminated - Stroke Clinical Trials

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

ARCADIA
Start date: January 19, 2018
Phase: Phase 3
Study type: Interventional

Objectives - Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. - Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

NCT ID: NCT03156764 Terminated - Clinical trials for Congenital Heart Disease

Qp/Qs Ratio by Noninvasive Methods in Children With Shunt Dependent Pulmonary Circulation

Start date: May 23, 2017
Phase:
Study type: Observational

In pediatric cardiac patients with shunt dependent pulmonary circulation, Qp/Qs ratio is a important parameter indicating the balance of pulmonaty and systemic circulation. This study will calculate Qp/Qs using variables measured using non-invasive monitors (cerebral oximeter and pulse oximeter). This value will be compared with Qp/Qs calculated using variables obtained from blood sample.

NCT ID: NCT03136900 Terminated - Clinical trials for Congenital Heart Disease in Children

Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants.

DIETCHIRCARD
Start date: May 3, 2017
Phase: N/A
Study type: Interventional

An adequate nutritional support after a cardiac surgery enhances the morbidity and mortality. After a cardiac surgery, the energy expenditure is estimated to be around 55 kcal/kg/d. The caloric intake is not the only important nutritional variable in PICU. The protein intake objective is around 1,5g/kg/d in order to reduce muscular catabolism. The aim of this study is to compare the impact of an isocaloric enteral diet, either fortified by milk concentration (in order to increase the protein intake) or by a supplement of maltodextrin and oil in children from 0 to 2 years, after surgery for congenital heart disease.

NCT ID: NCT03102437 Terminated - Heart Failure Clinical Trials

Continued Access Protocol for the Evaluation of the OPTIMIZER Smart System

FIX-HF-5CA
Start date: July 1, 2017
Phase: N/A
Study type: Interventional

This is a multicenter, prospective, single-arm Continued Access study of the Optimizer Smart System with CCM therapy.

NCT ID: NCT03068286 Terminated - Depression Clinical Trials

iCBT for Long-term Conditions in IAPT

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

SilverCloud provides internet-delivered interventions for depression and anxiety in NHS Mental Health Services. The interventions have proved successful in the management of depression and anxiety for clients presenting to mental health services, with recovery rates exceeding the national standard. Recently SilverCloud has embarked on tailoring the interventions for patients with long-term conditions including COPD, pain and diabetes. The purpose of the customisation is to make the interventions more meaningful and relevant to patients with LTCs, but all the while having the same goal of addressing depression and anxiety disorders. In doing so it would be expected that individuals might be in a better position to effectively self-manage their LTC. The current study, therefore, seeks to assess the possible effectiveness of implementing customised internet-delivered interventions for depression and anxiety for people with long-term conditions presenting to NHS mental health services.

NCT ID: NCT03007537 Terminated - Surgery Clinical Trials

The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury

Start date: October 1, 2015
Phase: N/A
Study type: Interventional

To testify the prevention of Erythropoietin on cardiac surgery associated-acute kidney injury, and trying to provide evidence for protecting the renal function and improving the prognosis for patients after cardiac surgery.

NCT ID: NCT02952287 Terminated - Clinical trials for Congenital Heart Disease (CHD)

Assessment of Flow With the New Four-dimensional Velocity-encoded Magnetic Resonance Imaging Technique

4D Flow
Start date: November 2016
Phase: N/A
Study type: Interventional

The purpose of our study is to validate the accuracy of 4D PC flow method in quantification of thoracic and upper abdominal blood flow volumes in children. In this validation study, 4D PC flow method will be applied in 100 pediatric patients undergoing clinically indicated CMR with 2D PC flow measurement.

NCT ID: NCT02893579 Terminated - Clinical trials for Ischemic Heart Disease

Stress Reduction Intervention for Women With Ischemic Heart Disease

Start date: March 6, 2018
Phase: N/A
Study type: Interventional

This is a single center, randomized controlled trial which will include women with ischemic heart disease to receive either a self-directed stress reduction program delivered through a smart-phone application or activity tracking only for the first month ("early SR intervention" and "delayed SR intervention", respectively). Patients will be monitored for 1 month for application use and step counts via telephone or email interview and/or collection of screen-captured data. Baseline questionnaires will be repeated at the end of one month to assess for all primary and secondary measures, at which time the control group (activity tracking only) will be introduced to the intervention program. The early SR intervention group will not receive a new intervention but will be encouraged to continue using the app. Data will be collected for an additional 2 months with all participants in both groups. After the three-month study period, the study will close with the collection of final questionnaire data.

NCT ID: NCT02818959 Terminated - Clinical trials for Cardiovascular Diseases

First in Man Study of the JenaValve TAVI Plus System Transfemoral

CP-0001
Start date: December 2013
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate feasibility, safety and effectiveness of the first generation transfemoral JenaValve Pericardial TAVR System (formerly named JenaValve TAVI Plus System- Transfemoral) in an elderly patient population with severe aortic stenosis who are at high risk for surgical aortic valve replacement.