View clinical trials related to Healthy.
Filter by:The primary objective of the study is to evaluate the safety and tolerability of single intravenous (IV) doses of REGN5381 in healthy normotensive and otherwise healthy hypertensive adults. The secondary objectives of the study are: - To evaluate the effect of single IV doses of REGN5381 on blood pressure (BP) and heart rate (HR) in healthy normotensive and otherwise healthy hypertensive adults - To evaluate the effect of single IV doses of REGN5381 on cardiac stroke volume (SV) - To evaluate the pharmacokinetics (PK) of single IV doses of REGN5381 - To evaluate the immunogenicity of single IV doses of REGN5381
This study evaluates SKL24741 safety and tolerability in healthy subjects. Subjects will be randomized to receive oral doses of SKL24741 or placebo. This is a two-part, double-blinded, randomized study of SKL24741.
This study is a randomized controlled trial (RCT) which investigates the effect of a Future-Self Avatar intervention (FutureMe App) on physical activity (PA) and nutrition. The Health Action Process Approach (HAPA) and principles from consumer behavior theory were used to guide the development of the intervention. The study investigates the impact of avatar-based interventions on PA and food purchasing behavior and aims to understand if avatars can help increase the stand-alone effectiveness of mHealth interventions.
The purpose of this First-in-Human study is to evaluate the safety , tolerability，PK and PD after single ascending of HNC664 given to healthy subjects, compared to placebo. Also, food effect will be evaluated.
The main purpose of this study is to evaluate the safety and tolerability after multiple-dose administrations of macitentan with titration regimen starting from Dose 1 once daily (qd) up to Dose 2 qd in Japanese healthy adult male participants (Part 1) and to evaluate the effect of food on pharmacokinetics of macitentan and its active metabolite (ACT-132577) in Japanese healthy adult male participants with macitentan Dose 3 tablet (Part 2).
This study will be an 8-week randomized controlled trial examining the effects of a YouTube-delivered aerobic and muscle strengthening physical activity intervention on university students' physical activity, fitness, sleep quality, and psychosocial health outcomes. Participants will be randomized into 1 of 2 groups: (1) intervention group (receive twice-weekly YouTube videos [1 aerobic workout video; 1 muscle-strengthening workout video] for 8 weeks); or (2) control group (receive twice-weekly YouTube videos with general health information [no physical activity-related information or workouts] for 8 weeks). Baseline (0 weeks), mid-point (4 weeks), and post-test (8 weeks) testing will take place and the following outcome measures will be assessed at these time points: participants' free-living (7-day) objectively-measured physical activity and sleep quality data will be collected; anthropometric measures (height, weight, percent body fat); cardiorespiratory and muscular fitness; and psychosocial assessments (perceived physical activity barriers and social support).
The main purpose of this study in healthy participants is to learn more about the safety of LY3493269 and any side effects that might be associated with it. Blood tests will be performed to check how much LY3493269 gets into the bloodstream and how long it takes the body to eliminate it. For each participant, the study will last about 10 weeks and may include 12 visits, including five nights in a row in the clinical research center.
Structured exercise and physical activity are well known to not only improve physical fitness, but also alter various health parameters in a positive fashion. To yield health benefits, exercises need to meet certain characteristics e. g. specific levels of intensity or duration.To evaluate intensity levels and therefor possible improvements in physical conditioning in golf the investigators conducted this study with two groups of each 10 subjects. The groups differed in age and skill level (handicap, hcp). Each group went through a exercise session on the driving range (DR) and a 9-hole compeition round of golf. The investigators assessed spirometrical data (breath-by-breath) to evaluate energy expenditure (EE) and intensity levels of physical activity according to the ACSM guidelines.
This study evaluates a new formulation of ramucirumab, a drug approved for several types of cancer. In this study of healthy participants, a small amount of ramucirumab will be given by injection either into a vein or just under the skin. Study doctors will measure the amount of ramucirumab in the bloodstream. Side effects and tolerability will be documented. The study will last for about 16 weeks for each participant, including screening and follow up. Screening is required within 28 days prior to entering the study.
The purpose of this study is to estimate the prevalence of genetic variants associated with liver disease in participants who are known, or are likely to have NAFLD.