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Diabetes Mellitus clinical trials

View clinical trials related to Diabetes Mellitus.

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NCT ID: NCT03529123 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-India)

Start date: May 30, 2018
Phase: Phase 3
Study type: Interventional

Primary Objective: To demonstrate the superiority of the insulin glargine/lixisenatide fixed ratio combination (FRC) to insulin glargine by demonstrating change in glycosylated hemoglobin (HbA1c). Secondary Objectives: - To assess the effects of the FRC in comparison with insulin glargine on: - Percentage of patients reaching HbA1c targets (<7% ); - Glycemic control in relation to a meal as evaluated by 2-hour Post-prandial Plasma Glucose; (PPG); - Body weight - Fasting Plasma Glucose (FPG); - Percentage of patients reaching HbA1c targets of <7% with no body weight gain and no hypoglycemia (as defined in the evaluation criteria); - 7-point Self-Monitoring Plasma Glucose (SMPG) profile; - Insulin glargine dose. - To assess the safety and tolerability in each treatment group.

NCT ID: NCT03528811 Recruiting - Clinical trials for Peripheral Vascular Disease in Diabetes

Evaluation of Microcirculation of Peripheral Vascular Disease in Diabetes

Start date: August 1, 2016
Phase: Phase 1
Study type: Interventional

The main aim of the present study was to evaluate the microcirculation of peripheral vascular disease in diabetes.

NCT ID: NCT03528226 Not yet recruiting - Type1diabetes Clinical Trials

Exercise Training and Endothelial Function in Type 1 Diabetes

EVaDia
Start date: May 2018
Phase: N/A
Study type: Interventional

Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental. In this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences. An improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected

NCT ID: NCT03528174 Recruiting - Clinical trials for Type 1 Diabetes Mellitus

Single Hormone Closed Loop Study With PDT Sensor

Start date: April 16, 2018
Phase: N/A
Study type: Interventional

The study described within this protocol is designed to test a single hormone closed-loop algorithm for managing blood glucose in type 1 diabetes using insulin only and a new device for measuring glucose continuously in the immediate vicinity of subcutaneous insulin delivery. Subjects will undergo one all day closed loop study using insulin only. The closed loop insulin only system includes a Dexcom G5 transmitter, a Nexus 5 smart phone and two Tandem tslim pumps connected to two Pacific Diabetes Technologies glucose sensing cannulas. The closed loop system will be started after G5 2 hour sensor start-up with an IV catheter for frequent blood withdrawal for 10 hours.

NCT ID: NCT03527667 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Incentivized Smoking Cessation for Diabetics

Start date: May 15, 2018
Phase: N/A
Study type: Interventional

This pilot study aims to test the feasibility of providing incentives to patients with T2D contingent on remote biochemical verification using a smartphone carbon monoxide (CO) monitor. We will use an ecological momentary assessment (EMA) smartphone application and CO sensor to monitor urges to smoke, stressors, smoking behaviors, and to validate continuous abstinence throughout the intervention. Two different contingency management structures will be explored to investigate the length of time incentives need to be offered.

NCT ID: NCT03527641 Recruiting - Insulin Resistance Clinical Trials

United for Health: Type 2 Diabetes Prevention in Latino Teens

UNITED
Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This study pilots the feasibility and acceptability of a family-based lifestyle intervention for decreasing diabetes risk called "Salud sin Barreras" (meaning, "Health without Barriers") delivered in the community to Latino teens at risk for type 2 diabetes. This program combines traditional lifestyle intervention to change eating and physical activity with learning mindfulness-based stress reduction tools. We also are exploring how Salud sin Barreras lowers stress and improves insulin resistance in Latino teens, as compared to lifestyle-only intervention, the "La Vida Saludable" (meaning, the Healthy Living Program; HeLP).

NCT ID: NCT03527537 Not yet recruiting - Clinical trials for Gestational Diabetes

Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes

TIME
Start date: August 1, 2018
Phase: Phase 4
Study type: Interventional

The goal of this study is to compare two different thresholds for initiation of medical treatment for GDM. Pregnant women diagnosed with GDM will be randomized to either start pharmacotherapy when they have reached at least 20% or at least 40% of capillary blood glucose (CBG) values above the target goal. The investigators hypothesize that a lower threshold of 20% elevated CBG levels, compared to 40%, will lead to lower rates of obstetric and medical complications.

NCT ID: NCT03527277 Recruiting - Metabolic Syndrome Clinical Trials

Orange Juice And Sugar Intervention Study

OASIS
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The objectives of this proposal are to address the gaps in knowledge regarding the metabolic effects of consuming orange juice, the most frequently consumed fruit juice in this country, compared to sugar-sweetened beverage.

NCT ID: NCT03526536 Recruiting - Diabetes Mellitus Clinical Trials

Pilot: A Comparison of Insulin Sensitivity and Management in Hyperglycemic Patients in the Perioperative Period: ESRD vs. Non-ESRD

Start date: May 1, 2018
Phase: Phase 4
Study type: Interventional

This study is for people with diabetes who have either healthy kidneys or who have end stage renal disease (ESRD) and are on hemodialysis that are having surgery. This research will help increase our knowledge about how having diseased kidneys and being on hemodialysis changes how the body responds to insulin. In the time period directly before, during, and after surgery, maintenance of blood sugar within normal physiological range is essential. When patients come for surgery and have an elevated blood sugar, it is up to each individual physician to decide on the right amount of insulin to treat them. Currently, there are many different protocols across the country to treat elevated blood sugar; however, there is no one specific protocol to treat elevated blood sugar at SUNY Downstate Medical Center at this time. In this study, we will evaluate the change in blood sugar following insulin administration to determine whether there is a significantly different response between ESRD and non-ESRD patients. The results of the study will help develop safer practice guidelines to patients with ESRD with an elevated blood sugar while they are having surgery.

NCT ID: NCT03526445 Recruiting - Diabetes Mellitus Clinical Trials

Hepatic Metabolic Changes in Response to Glucagon Infusion

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to investigate how exogenously administered glucagon affects hepatic lipid, glucose and protein metabolism as well as appetite, food intake and resting energy expenditure.