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Diabetes Mellitus clinical trials

View clinical trials related to Diabetes Mellitus.

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NCT ID: NCT03922087 Recruiting - Obesity Clinical Trials

No-worry Baby Project

Start date: November 20, 2018
Phase:
Study type: Observational

The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.

NCT ID: NCT03922022 Not yet recruiting - Hypertension Clinical Trials

Exercise is Medicine: a Pilot Study

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Background: Regular exercise is beneficial to patients with hypertension and/or diabetes mellitus. However, most patients cannot maintain exercise habit. The investigators had developed a program called the "exercise is medicine"(EIM), combining motivational technique, information technology use and teaching exercise techniques. Before using this intervention in a main randomized controlled trial, the investigators would like to test its feasibility and acceptability. It is hypothesized that this program is feasible and acceptable to patients. Method: 40 patients with HT and/or DM will be recruited to attend the EIM intervention. Primary outcomes will be the rate of recruitment and rate of retention. Other clinical outcomes will be obtained before and immediately after the 12-week program.

NCT ID: NCT03921593 Recruiting - Diabetes Mellitus Clinical Trials

Quality of Life in Pancreas Transplantation

Start date: November 4, 2018
Phase:
Study type: Observational [Patient Registry]

Quality of Life for individuals with Insulin Dependent Diabetes Mellitus (IDDM) can be severely impaired by acute and chronic complications of the disease. Solid organ pancreatic transplantation restores endocrine pancreatic function. However, it is also burdened by high perioperative morbidity and mortality. Clinical benefits and risks of this intervention have been extensively clarified, but our knowledge about quality of life gain, often mentioned among the assets of transplantation, is still limited. This study aims to quantify the impact of all forms of Solid Organ Pancreas Transplantation on quality of life (QOL).

NCT ID: NCT03921242 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease

Start date: August 1, 2019
Phase:
Study type: Observational

This is a proposal for a retrospective observational study of the safety of metformin use in patients with chronic kidney disease, compared to other commonly used diabetes drugs. It will be conducted using retrospective data from the New York City CDRN, Medicare administrate files, and New York State Medicaid administrative files, which will be linked and then deidentified prior to analysis.

NCT ID: NCT03921216 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Cholesterol Metabolism in Plasma and Interstitial Fluid Among Subjects Undergoing Hemodialysis.

Start date: April 17, 2019
Phase:
Study type: Observational

Because the atherosclerosis process partly occur in the intercellular space of the vessel wall, the determination of the constitution of lipoproteins in the interstitial fluid may expand our knowledge about the atherosclerosis process and lead to a better understanding of what constitutes the increased risk of developing cardiovascular disease in patients with chronic diseases. We hypothesize that the apoB-containing particles in T2D patients are more susceptible to be retained or consumed in the intercellular compartment, which in turn could be one explanation for the elevated risk of atherosclerosis. We hypothesise that with the progression of chronic kidney disease this process is further increased. Patients undergoing dialysis are known to have a very high risk of cardiovascular disease. We now want to study the cholesterol metabolism in interstitial fluid in subjects undergoing hemodialysis because of diabetic nephropathy and in subjects undergoing hemodialysis because of chronic kidney disease of other causes.

NCT ID: NCT03921203 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

ApoB48 Metabolism in Plasma and Interstitial Fluid

Start date: April 17, 2019
Phase:
Study type: Observational

Postprandial increases in the levels of atherogenic chylomicron remnant lipoprotein particles have long been considered a presumable risk factor for the development of atherosclerosis with time, also in normolipidemic subjects. apoB-48 (Chylomicron) in blood is a specific marker for intestinal derived lipoproteins. Specific aim: To determine if apoB-48 containing lipoproteins may appear in IC in the postprandial state after a standard meal and investigate the effect fasting and feeding have on levels of lipids, apolipoproteins and the cholesterol component of lipoproteins in IF and plasma. Methodology: Intercellular fluid will be collected using the cup technique. IF will be collected in intervals corresponding to different periods after food intake. The IF from these different occasions will then be analysed and compared using FPLC and Elisa.

NCT ID: NCT03920397 Enrolling by invitation - Clinical trials for Type 1 Diabetes Mellitus

Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus

Start date: March 1, 2015
Phase: N/A
Study type: Interventional

In this prospective, dual-center, open trial, patients with recent onset type 1 diabetes will receive one dose of allogenic Adipose tissue-derived stromal/stem cells (1x106 cells/kg) and oral cholecalciferol 2000UI/day for 24 months (group 1). They will be compare to patients that will receive just oral cholecalciferol 2000UI/day (group 2) and standard treatment (group 3: no treatment). Adverse events will be record. In addition, glycated hemoglobin, insulin dose, frequency of hypoglycemia, glycemic variability, % of time in hyper and hypoglycemia and peak response of the C-peptide after the mixed meal teste wil be measure at baseline (T0), after 3 (T3), 6 (T6), 12 (T12), 18 (T18), and 24 (T24) months.

NCT ID: NCT03920085 Completed - Diabetes Mellitus Clinical Trials

Clinical Evaluation of LifeScan Blood Glucose Monitoring Systems

Start date: January 8, 2019
Phase: N/A
Study type: Interventional

Study to determine the performance of the LifeScan BGMS when conducted at MAC clinical site.

NCT ID: NCT03919877 Recruiting - Insulin Resistance Clinical Trials

Precision Diets for Diabetes Prevention

Start date: May 24, 2018
Phase: N/A
Study type: Interventional

With this study the investigators want to understand the physiological differences for people developing pre-diabetes and diabetes. The investigators hypothesize that different individuals go through different paths in the development of the disease. By understanding the personal mechanism for developing disease, the investigators will find a personalized approach to prevent that development. The investigators are also hoping to be able to find a biomarker that will pinpoint to the particular defect and thus, diagnose the problem at an earlier stage and have the information to give personalized diet recommendations to prevent the development of diabetes more effectively.

NCT ID: NCT03919656 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

SGLT-2 Inhibition, Metabolomics and Cardiovascular/Kidney Disease

Start date: May 2019
Phase: Phase 4
Study type: Interventional

This study evaluates the metabolomics changes associated with dapagliflozin treatment in patients with type 2 diabetes mellitus (T2DM). The participants in the study will be randomized to receive 10 mg dapagliflozin or placebo once daily for 12 weeks.