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Diabetes Mellitus clinical trials

View clinical trials related to Diabetes Mellitus.

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NCT ID: NCT03589092 Recruiting - Clinical trials for Gestational Diabetes

Genetic Causes of Gestational Diabetes in the Emirati Population

Start date: January 1, 2017
Phase:
Study type: Observational

The study aims to identify the number of MODY patients to be found among Emirati women with GDM as the incidence and prevalence of monogenic diabetes among this group of patients is unknown. This will enable improvements in diagnostics, treatment and the counselling of these women.

NCT ID: NCT03588234 Recruiting - Type1diabetes Clinical Trials

Food Literacy and Type 1 Diabetes

Start date: June 28, 2018
Phase:
Study type: Observational

The objective of the current study is to assess the prevalence of poor food literacy in young adults with type 1 diabetes through a national on-line survey. More specifically, the research question to be investigated as part of this project is: What is the current level of food literacy among young adults with type 1 diabetes? We hypothesize that at least 50% of young adults with type 1 diabetes have a poor level of food literacy.

NCT ID: NCT03588104 Not yet recruiting - Diabetes Mellitus Clinical Trials

"POWER2DM Evaluation Campaign"

POWER2DMEC
Start date: August 2018
Phase: N/A
Study type: Interventional

Rationale: Hyperglycaemia is an important cause of long-term macro-and microvascular complications in all patients with diabetes mellitus. However, only a small fraction of the patients with diabetes reaches the set target of glycemic control. Problems with adequate self-management usually underlie problems to maintain glycaemic control. Thus, patients need more support in order to reduce the burden and increase the effectiveness of their diabetes self-management. One way to do this is by using integrated technologies and personalized plans for diabetes care. For this purpose, the POWER2DM support system was developed to give patients insight into their condition and support diabetes patients and their health care professionals in setting and achieving self-management goals using predictive computer model simulations and behavioural action plans. Objective: To provide proof of concept that POWER2DM is safe and effective in improving glycaemic control, improving behavioural/psychosocial and lifestyle markers, and to assess the cost-effectiveness of the approach and to highlight any potential issues that may impede implementation. Study design: This is a pragmatic randomised controlled trial with 9 months follow-up in which patients will be randomised 1:1 to either Power2DM support (Power2DM group) or usual care (usual care group). There will be evaluation moments at baseline, after 11 weeks, 22 weeks and 37 weeks. Study population: 230 patients with diabetes (N=115 T2DM, N=115 T1DM) recruited from out-patient clinics in the Netherlands (Leiden University Medical Centre and affiliating teaching hospitals N=115) and Córdoba, Spain (Reina Sofia University Hospital N=115). Intervention: The POWER2DM support group will receive access to the prototype 2 of the POWER2DM system. This system consists of two components: 1) the web-based Shared Decision Making Dashboard, used to set self-management goals together with a health care professional with the use of both short- and long-term predictive computer simulation models, and 2) the POWER2DM Self-Management Support System as a mobile application and webpage, used to support behavioural change in DM self-management. The system is fed with data from an activity tracker, a glucose monitor and manual data entry. Main study parameters/endpoints: Change in glucose regulation as measured by %HbA1c before and after the intervention compared between the intervention and control group.

NCT ID: NCT03588000 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

The Effect of Remote SMBG Combined With the Application of APP on the Improvement of T2DM Management in the Community

Start date: August 2018
Phase: N/A
Study type: Interventional

To investigate whether strengthen community diabetes patients self-monitoring of blood glucose can improve the patient's blood glucose control under Chinese guidelines for the prevention and treatment of diabetes (CDS 2017) and whether this intervention produces health and economic benefits.

NCT ID: NCT03587948 Recruiting - Diabetes Mellitus Clinical Trials

Shanghai Children and Adolescent Diabetes Eye Study

SCADE
Start date: January 1, 2018
Phase:
Study type: Observational

To compare the prevalence of eye disease between children and adolescents with diabetes mellitus and healthy people, and to analyze the related factors of eye diseases in diabetic patients.

NCT ID: NCT03586830 Recruiting - Obesity Clinical Trials

A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Participants With Type 2 Diabetes Mellitus

Start date: June 27, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the effects of JNJ-64565111 compared with placebo in severely obese Type 2 Diabetes Mellitus (T2DM) participants after 12 weeks of treatment on: the percentage change in body weight from baseline and safety and tolerability.

NCT ID: NCT03585153 Recruiting - Diabetes Mellitus Clinical Trials

MRI of the Pancreas in Type 1 Diabetes

Start date: February 19, 2014
Phase:
Study type: Observational

This research applies new magnetic resonance imaging (MRI) techniques to study the pancreas of patients who were recently diagnosed with type 1 diabetes (T1D). The MRI techniques used include both standard anatomical imaging, which has shown that pancreas size is smaller in patients with T1D, as well as advanced quantitative MRI techniques that have not previously been used to study the pancreas in T1D. These advanced MRI techniques image the structure and chemical composition of the body and may be sensitive to changes in the pancreas that occur during T1D. MRI is performed three times in the first year after diagnosis of type 1 diabetes to determine changes in the pancreas that occur as disease progresses. Patients without T1D are also imaged with these advanced MRI techniques to determine differences in the pancreas in people with T1D. The advanced MRI techniques may discover changes that occur in the pancreas with type 1 diabetes that are currently not known. Discovery of unknown changes may lead to new ways to treat disease. The MRI techniques may also be useful for following how T1D is progressing in different people, determining whether new drugs are effective, and ultimately detecting T1D in people earlier than currently possible.

NCT ID: NCT03584217 Not yet recruiting - Obesity Clinical Trials

Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study

Renal-HEIR
Start date: July 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Type 2 diabetes (T2D) in youth is increasing in prevalence in parallel with the obesity epidemic. In the US, almost half of patients with renal failure have DKD, and ≥80% have T2D. Compared to adult-onset T2D, youth with T2D have a more aggressive phenotype with greater insulin resistance (IR), more rapid β-cell decline and higher prevalence of diabetic kidney disease (DKD), arguing for separate and dedicated studies in youth-onset T2D. Hyperfiltration is common in youth with T2D, and predicts progressive DKD. Hyperfiltration may also be associated with early changes in intrarenal hemodynamic function, including increased renal plasma flow (RPF) and glomerular pressure. Despite the high prevalence and gravity of DKD in youth-onset T2D, widely effective therapeutic options are lacking. The investigators' preliminary data support a strong association between IR and hyperfiltration in youth-onset T2D, but the pathology contributing to this relationship remains unclear. A better understanding of the pathophysiology underlying hyperfiltration and its relationship with IR is critical to inform development of new therapeutics. The investigators' overarching hypotheses are that: 1) hyperfiltration in youth-onset T2D is associated with changes in intrarenal hemodynamics, resulting in increased renal oxygen demand, 2) the demand is unmet by the inefficient fuel profile associated with IR (decreased glucose oxidation and increase free fatty acid [FFA] oxidation), resulting in renal hypoxia and ultimately renal damage. To address these hypotheses, the investigators will measure peripheral insulin sensitivity, adipose insulin sensitivity (FFA suppression), glomerular filtration rate (GFR), RPF, and renal oxygenation in youth with T2D (n=30), obesity (n=20) and in lean (n=20) controls.

NCT ID: NCT03583593 Completed - Clinical trials for Diabetes Mellitus, Type 2

Evaluation of DIAMEL® Combined With Insulin in Diabetic Foot Ulcer

Start date: May 23, 2014
Phase: Phase 2
Study type: Interventional

Diabetic foot syndrome is one of the most frequent complications in type 2 diabetic patients. The present work is carried out with the objective of evaluating the use of DIamel combined with insulin in diabetic foot ulcers. Method. Phase II clinical trial. A study group was created that receives the active product and another control group that receives a placebo. Double-blind study with a monthly follow-up for the first 6 months and then quarterly until the end of 1 year. Complementary tests are performed every 6 months to evaluate metabolic, lipid and renal function control.

NCT ID: NCT03582956 Not yet recruiting - Adiposity Clinical Trials

Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes

T1D
Start date: August 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effects of adiposity on resistance to insulin's ability to suppress hepatic glucose production and to stimulate peripheral glucose metabolism in adolescents with type 1 diabetes. In addition, this study will also examine the role of fatty liver disease on the insulin resistance of obesity in adolescents with type 1 diabetes.