There are about 849 clinical studies being (or have been) conducted in Uganda. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Thought Field Therapy (TFT) is a simple technique that involves tapping on points of the body corresponding to the meridians used in acupuncture. By using specific sequences, TFT can be used to treat a variety of psychological problems. Patients can be taught to treat themselves, and lay people can be trained to treat others in their community, as has been shown for narrative exposure therapy. Thought Field Therapy has been used to treat whole communities who have suffered psychological trauma following natural disasters and violent conflicts. In these circumstances, TFT can be used as a stand-alone therapy, or as an adjunct to other psychological therapies, by removing the pain of re-living the traumatic events. Studies in Rwanda have shown that individuals within a community can be treated with brief TFT sessions. Both short-term and longer-term improvements in scores of Post-Traumatic Stress Disorder (PTSD) measurement scales have been demonstrated. The Kasese District has suffered from factional conflicts and the consequences of the ongoing struggles in neighbouring countries for many years. Although the government has controlled the situation and secured the borders, many are still haunted by the psychological consequences. The purpose of the study is to validate the model of addressing widespread psychological trauma following conflict by training community leaders to help others in their community using TFT. Thirty-six community leaders will be given a two-day training in algorithm level trauma-relief TFT. They will then treat 128 volunteers for their traumas, using TFT, who will be assessed before and after treatment by the post-traumatic stress disorder check-list questionnaire for civilians (PCL-C). As a control, a further 128 volunteers will join a wait-list group, who will be assessed at the same time, but treated later. PCL-C scores before and after treatment will be compared with the wait-list group scores before and after waiting, but before their treatment. A follow-up assessment of the participants will be undertaken 1 to 2 years later.
The purpose of this study is to determine whether use of the Good Schools Toolkit is effective in reducing violence against children in primary schools.
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the introduction of this method.
The purpose of this study is to assess the feasibility and impact of introducing subsidized malaria rapid diagnostic tests (RDTs) into retail sector drug shops in Uganda. This is a randomized controlled trial at the village level, taking place in 6 districts in Eastern Uganda. Licensed drug shops in selected villages were trained in proper RDT storage, administration, interpretation and disposal and were given access to subsidized RDTs for sale. This study explores whether drug shop owners--when given access to training and subsidized RDTs--will choose to promote and sell RDTs to customers and, if so, at what volume and what price. The investigators also explore whether shops will safely store, administer, interpret and dispose of RDTs and to what extent they will use RDT results to guide treatment recommendations. Finally, the study explores whether making RDTs available for sale in local drug shops has a community level impact on diagnostic testing and appropriate treatment for malaria.
The study was done to: - test a strategy of using a resistance test to choose anti-HIV drugs - see how well combinations of new anti-HIV drugs work to lower HIV infection - see if taking new anti-HIV drugs together is safe and tolerable - see if text messages improve people's anti-HIV drug-taking behavior (only at sites participating in the adherence study) - in people taking certain combinations of anti-HIV drugs with an anti-TB drug, compare how these drugs act in the body - to see how people do after they stop having frequent clinic visits as part of a research study
Early childhood (up to age 5 yrs) is a period of dramatic change in the cognitive, emotional, social, and behavioral domains; children continuously progress by observing and interacting with the world around them. In the face of economic instability and nutritional, medical and educational deprivation, HIV-affected very young children are the most vulnerable HIV subgroup globally because their families are often the most vulnerable, with little margin for sustaining a favorable developmental milieu for the child. Through strategic caregiver interventions during this sensitive period of child neurodevelopment, our study findings have the potential for positively re-directing the developmental trajectories of tens of millions of HIV-affected children globally.
The purpose of this study was to see if antiretroviral therapy (ART) is safe and works at getting rid of malaria in blood and to see whether one type of ART is better than another. This study may offer information for further research in looking at whether ART plays a role in the prevention and treatment of malaria.
This is a double-blind, randomised, placebo-controlled study to assess the safety and efficacy of a silicone elastomer vaginal matrix ring.
The purpose of this study is to determine the effectiveness of different sales offers and different marketing messages to increase the uptake of energy efficient cookstoves. This research will address the following major barriers to the acquisition and correct use of improved cookstoves into four main categories: - Inappropriate product or marketing for intended users - Lack of consumer trust in new products - Failure to address consumers' financial constraints - Failure to achieve behavioral change To do so this research includes 3 Randomized Controlled Trials including:RCT 1- Testing the Effectiveness of Marketing Messages in Increasing Willingness to Pay; RCT 2- Testing the Effectiveness of the Novel Sales Offer and its ability to Increase Uptake of Purchasing Energy Efficient Cookstoves; and RCT 3-Measure the Effects of Fuel Efficient Cookstoves on Health, Fuel Use and Time Spent Collecting Fuel. RCT 1 studies the price women are willing to pay for the improved stove. It will also test the effects of the two most effective marketing messages identified during the Phase 1 Feasibility stage (e.g., improved health, saves time, and has high status) on increasing willingness to pay. RCT 1 will run second price auctions in 36 parishes with an average of 60 participants per meeting. From RCT 1, RCT 2 tests the effect of a Novel Sales Offer- which includes a free trial, and time payments- on purchasing decisions of participants versus those that receive the Traditional Offer- a cash and carry offer. Based on a pilot in urban Kampala conducted by Dr. David I. Levine (co-P.I. on this project) results show a 44% uptake for households offered the novel offer vs. a 4% uptake for those offered the traditional offer. The hypothesis is a novel offer will significantly increase uptake of fuel efficient cookstoves in rural Uganda when compared to a traditional offer. RCT 3 measures the impacts of fuel efficient cookstoves on health, fuel usage, and time spent collecting fuel. For RCT 3 we will randomize those who accept the Novel Offer into early and late groups. To measure the impacts of improved stoves on health, fuel use, time spent collecting fuel, etc., there will be a baseline and follow-up survey and associated quantitative measures on our full sample and a small endline on select quantitative measures for a sub-sample.
Real-time Wireless Adherence Monitoring to HIV Antiretroviral Therapy in Rural Uganda.